node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ava_2035 | Ava_2757 | Ava_2035 | Ava_2757 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
Ava_2035 | Ava_3533 | Ava_2035 | Ava_3533 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.999 |
Ava_2035 | ilvC | Ava_2035 | Ava_0133 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
Ava_2035 | ilvD | Ava_2035 | Ava_0023 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.917 |
Ava_2597 | coaE | Ava_2597 | Ava_0282 | 4'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.908 |
Ava_2757 | Ava_2035 | Ava_2757 | Ava_2035 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
Ava_2757 | Ava_3533 | Ava_2757 | Ava_3533 | Acetolactate synthase, large subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.918 |
Ava_2757 | ilvC | Ava_2757 | Ava_0133 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
Ava_2757 | ilvD | Ava_2757 | Ava_0023 | Acetolactate synthase, large subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.971 |
Ava_2981 | panB | Ava_2981 | Ava_3909 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.934 |
Ava_2981 | panC/cmk | Ava_2981 | Ava_0964 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.937 |
Ava_3533 | Ava_2035 | Ava_3533 | Ava_2035 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.999 |
Ava_3533 | Ava_2757 | Ava_3533 | Ava_2757 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.918 |
Ava_3533 | ilvC | Ava_3533 | Ava_0133 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.990 |
Ava_3533 | ilvD | Ava_3533 | Ava_0023 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.920 |
Ava_3615 | panC/cmk | Ava_3615 | Ava_0964 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.925 |
Ava_3615 | panD | Ava_3615 | Ava_3547 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.907 |
Ava_3811 | coaD | Ava_3811 | Ava_1966 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.947 |
Ava_3811 | coaE | Ava_3811 | Ava_0282 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.522 |
Ava_3811 | coaX | Ava_3811 | Ava_1801 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Putative transcriptional acitvator, Baf; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.931 |