(16 nodes) Base excision repair network (Halobacillus dabanensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	polA_1	DNA polymerase I, thermostable. (648 aa)
	nfo	Putative endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (297 aa)
	recJ	Single-stranded-DNA-specific exonuclease RecJ. (775 aa)
	mutM	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (279 aa)
	polA_2	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (879 aa)
	ypcP	5'-3' exonuclease. (291 aa)
	pdg	UV-endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa)
	ung	Uracil-DNA glycosylase. (224 aa)
	yfhQ	Putative A/G-specific adenine glycosylase YfhQ; Adenine glycosylase active on G-A mispairs. (362 aa)
	alkA	DNA-3-methyladenine glycosylase. (289 aa)
	ligA	DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (668 aa)
	CDQ20988.1	Hypothetical protein; Phage/plasmid primase, P4 family, C-terminal domain. (456 aa)
	CDQ20989.1	Hypothetical protein; Bifunctional DNA primase/polymerase, N-terminal. (231 aa)
	ogt_2	Methylated-DNA--protein-cysteine methyltransferase, constitutive; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (182 aa)
	CDQ21572.1	uracil-DNA glycosylase, family 4. (211 aa)
	polA_3	DNA polymerase I, thermostable. (816 aa)

Your Current Organism:

Halobacillus dabanensis

NCBI taxonomy Id: 240302
Other names: CGMCC 1.3704, H. dabanensis, Halobacillus dabanensis Liu et al. 2005, Halobacillus sp. D-8, JCM 12772, strain D-8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDQ20988.1	CDQ20989.1	BN982_03349	BN982_03350	Hypothetical protein; Phage/plasmid primase, P4 family, C-terminal domain.	Hypothetical protein; Bifunctional DNA primase/polymerase, N-terminal.	0.959
CDQ20988.1	polA_1	BN982_03349	BN982_00207	Hypothetical protein; Phage/plasmid primase, P4 family, C-terminal domain.	DNA polymerase I, thermostable.	0.761
CDQ20988.1	polA_2	BN982_03349	BN982_00531	Hypothetical protein; Phage/plasmid primase, P4 family, C-terminal domain.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.878
CDQ20988.1	polA_3	BN982_03349	BN982_04135	Hypothetical protein; Phage/plasmid primase, P4 family, C-terminal domain.	DNA polymerase I, thermostable.	0.442
CDQ20988.1	recJ	BN982_03349	BN982_00356	Hypothetical protein; Phage/plasmid primase, P4 family, C-terminal domain.	Single-stranded-DNA-specific exonuclease RecJ.	0.539
CDQ20988.1	ypcP	BN982_03349	BN982_00939	Hypothetical protein; Phage/plasmid primase, P4 family, C-terminal domain.	5'-3' exonuclease.	0.509
CDQ20989.1	CDQ20988.1	BN982_03350	BN982_03349	Hypothetical protein; Bifunctional DNA primase/polymerase, N-terminal.	Hypothetical protein; Phage/plasmid primase, P4 family, C-terminal domain.	0.959
CDQ21572.1	ung	BN982_03975	BN982_01867	uracil-DNA glycosylase, family 4.	Uracil-DNA glycosylase.	0.515
alkA	nfo	BN982_02794	BN982_00265	DNA-3-methyladenine glycosylase.	Putative endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.	0.534
alkA	ogt_2	BN982_02794	BN982_03569	DNA-3-methyladenine glycosylase.	Methylated-DNA--protein-cysteine methyltransferase, constitutive; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.	0.703
alkA	pdg	BN982_02794	BN982_01827	DNA-3-methyladenine glycosylase.	UV-endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.445
alkA	polA_2	BN982_02794	BN982_00531	DNA-3-methyladenine glycosylase.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.559
ligA	polA_2	BN982_02959	BN982_00531	DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.806
ligA	polA_3	BN982_02959	BN982_04135	DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.	DNA polymerase I, thermostable.	0.644
ligA	recJ	BN982_02959	BN982_00356	DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.	Single-stranded-DNA-specific exonuclease RecJ.	0.555
mutM	pdg	BN982_00530	BN982_01827	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	UV-endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.707
mutM	polA_1	BN982_00530	BN982_00207	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	DNA polymerase I, thermostable.	0.624
mutM	polA_2	BN982_00530	BN982_00531	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.992
mutM	polA_3	BN982_00530	BN982_04135	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	DNA polymerase I, thermostable.	0.624
mutM	ypcP	BN982_00530	BN982_00939	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	5'-3' exonuclease.	0.666