STRINGSTRING
FEN1 FEN1 MSH3 MSH3 TOF1 TOF1 CSM3 CSM3 MGG_02491 MGG_02491 MGG_04466 MGG_04466 MGG_13023 MGG_13023 MGG_08646 MGG_08646 MGG_06731 MGG_06731 MGG_06763 MGG_06763 MGG_16579 MGG_16579 MGG_05615 MGG_05615 MGG_05639 MGG_05639 MGG_06969 MGG_06969 MGG_06985 MGG_06985 MGG_05700 MGG_05700 MGG_11757 MGG_11757 MGG_15318 MGG_15318 MGG_09293 MGG_09293 MCM7 MCM7 MGG_02366 MGG_02366 MGG_04627 MGG_04627 MGG_02459 MGG_02459 MGG_02461 MGG_02461 MGG_02482 MGG_02482 MGG_10666 MGG_10666 MGG_04434 MGG_04434 MGG_11387 MGG_11387 MGG_01470 MGG_01470 MGG_15075 MGG_15075 MGG_04585 MGG_04585 MGG_11196 MGG_11196 MGG_07121 MGG_07121 MGG_07124 MGG_07124 MGG_01549 MGG_01549 MGG_15566 MGG_15566 MGG_01611 MGG_01611 MGG_01614 MGG_01614 MGG_07222 MGG_07222 MGG_07238 MGG_07238 MGG_15576 MGG_15576 MGG_11342 MGG_11342 MGG_01694 MGG_01694 MGG_01696 MGG_01696 MGG_15760 MGG_15760 MGG_01759 MGG_01759 MGG_14764 MGG_14764 MGG_15325 MGG_15325 MGG_01800 MGG_01800 MGG_01813 MGG_01813 MGG_15489 MGG_15489 MGG_08071 MGG_08071 MGG_12276 MGG_12276 MGG_08122 MGG_08122 MGG_04389 MGG_04389 MGG_04410 MGG_04410 MGG_15188 MGG_15188 MGG_06178 MGG_06178 MGG_09555 MGG_09555 MGG_07526 MGG_07526 MGG_09487 MGG_09487 MGG_16994 MGG_16994 MGG_05032 MGG_05032 MGG_05040 MGG_05040 MGG_05049 MGG_05049 MGG_16581 MGG_16581 MGG_05278 MGG_05278 MGG_08594 MGG_08594 MGG_03729 MGG_03729 MGG_17052 MGG_17052 MGG_12843 MGG_12843 MGG_06397 MGG_06397 MGG_03549 MGG_03549 MGG_06370 MGG_06370 MGG_03488 MGG_03488 MGG_03284 MGG_03284 MGG_03268 MGG_03268 MGG_16996 MGG_16996 MGG_16997 MGG_16997 MGG_03246 MGG_03246 MGG_03233 MGG_03233 MGG_03204 MGG_03204 MGG_03202 MGG_03202 MGG_03184 MGG_03184 MGG_00691 MGG_00691 MGG_00685 MGG_00685 MGG_00630 MGG_00630 MGG_00597 MGG_00597 MGG_00519 MGG_00519 MGG_00518 MGG_00518 MGG_00485 MGG_00485 MGG_01089 MGG_01089 MGG_01032 MGG_01032 MGG_00213 MGG_00213 MGG_00881 MGG_00881 MGG_00879 MGG_00879 MGG_00868 MGG_00868 MGG_00841 MGG_00841 MGG_00169 MGG_00169 MGG_11498 MGG_11498 MGG_00706 MGG_00706 MGG_00704 MGG_00704 MGG_04208 MGG_04208 MGG_04175 MGG_04175 MGG_08738 MGG_08738 MGG_01917 MGG_01917 MGG_17643 MGG_17643 MGG_12138 MGG_12138 MGG_03910 MGG_03910 MGG_03854 MGG_03854 MGG_03850 MGG_03850 MGG_17683 MGG_17683 MGG_04127 MGG_04127 MGG_04123 MGG_04123 MGG_02656 MGG_02656 MGG_02986 MGG_02986 MGCH7_ch7g688 MGCH7_ch7g688 RHM52 RHM52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa)
MSH3DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1151 aa)
TOF1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1214 aa)
CSM3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (357 aa)
MGG_02491DNA replication ATP-dependent helicase dna2. (1689 aa)
MGG_04466DNA mismatch repair protein mutS. (829 aa)
MGG_13023Replication factor C subunit 3. (404 aa)
MGG_08646DNA helicase; Belongs to the MCM family. (720 aa)
MGG_06731Uncharacterized protein. (192 aa)
MGG_06763DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (506 aa)
MGG_16579Uncharacterized protein. (1283 aa)
MGG_05615Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (785 aa)
MGG_05639DNA mismatch repair protein MutS. (947 aa)
MGG_06969Minichromosome loss protein 1. (854 aa)
MGG_06985RECA_2 domain-containing protein. (548 aa)
MGG_05700RecQ helicase MUSN. (1780 aa)
MGG_11757DNA damage response protein RcaA. (881 aa)
MGG_15318Uncharacterized protein. (463 aa)
MGG_09293DNA helicase; Belongs to the MCM family. (1029 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (815 aa)
MGG_02366Uncharacterized protein. (1005 aa)
MGG_04627DNA_mis_repair domain-containing protein. (928 aa)
MGG_02459DNA polymerase delta small subunit. (497 aa)
MGG_024613'-5' exonuclease domain-containing protein. (638 aa)
MGG_02482DNA replication licensing factor mcm10. (838 aa)
MGG_10666Meiosis-specific topoisomerase Spo11. (466 aa)
MGG_04434DNA replication complex GINS protein PSF1. (215 aa)
MGG_11387DNA repair protein RAD50. (1316 aa)
MGG_01470RECA_2 domain-containing protein. (387 aa)
MGG_15075Uncharacterized protein. (234 aa)
MGG_04585Crossover junction endonuclease MUS81. (594 aa)
MGG_11196Origin recognition complex subunit 4. (836 aa)
MGG_07121DNA mismatch repair protein mutL. (690 aa)
MGG_07124Replication protein A 32 kDa subunit. (275 aa)
MGG_01549DNA replication initiation factor Cdc45. (871 aa)
MGG_15566Uncharacterized protein. (980 aa)
MGG_01611DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
MGG_01614Cell division control protein; Belongs to the CDC6/cdc18 family. (598 aa)
MGG_07222DNA polymerase epsilon subunit B. (865 aa)
MGG_07238DNA polymerase kappa. (634 aa)
MGG_15576DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
MGG_11342DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (669 aa)
MGG_01694HORMA domain-containing protein. (454 aa)
MGG_01696Uncharacterized protein. (132 aa)
MGG_15760Uncharacterized protein. (1107 aa)
MGG_01759DNA helicase; Belongs to the MCM family. (896 aa)
MGG_14764Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2930 aa)
MGG_15325CMGC/RCK/MAK protein kinase. (808 aa)
MGG_01800Flap structure-specific endonuclease. (932 aa)
MGG_01813MRC1 domain-containing protein. (1407 aa)
MGG_15489C2H2-type domain-containing protein. (756 aa)
MGG_08071DNA polymerase. (1103 aa)
MGG_12276BRCT domain-containing protein. (1015 aa)
MGG_08122DNA helicase; Belongs to the MCM family. (873 aa)
MGG_04389Replication factor C subunit 2. (384 aa)
MGG_04410Origin recognition complex subunit. (744 aa)
MGG_15188Uncharacterized protein. (188 aa)
MGG_06178Uncharacterized protein. (441 aa)
MGG_09555Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (731 aa)
MGG_07526Replication factor C subunit 4. (358 aa)
MGG_09487Origin recognition complex subunit. (616 aa)
MGG_16994Uncharacterized protein. (83 aa)
MGG_05032DNA repair protein RAD5. (1166 aa)
MGG_05040Uncharacterized protein. (918 aa)
MGG_05049AAA domain-containing protein. (1266 aa)
MGG_16581Uncharacterized protein. (84 aa)
MGG_05278DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (454 aa)
MGG_08594BRCT domain-containing protein. (1244 aa)
MGG_03729CAMK/CAMKL/CHK1 protein kinase. (551 aa)
MGG_17052Uncharacterized protein. (397 aa)
MGG_12843RRM domain-containing protein. (323 aa)
MGG_06397DNA polymerase. (1482 aa)
MGG_03549DNA repair protein rhp54. (803 aa)
MGG_06370DNA ligase. (896 aa)
MGG_03488CDC7 protein kinase. (497 aa)
MGG_03284DNA mismatch repair protein. (947 aa)
MGG_03268DUF1767 domain-containing protein. (265 aa)
MGG_16996Helicase C-terminal domain-containing protein. (327 aa)
MGG_16997Uncharacterized protein. (1140 aa)
MGG_03246Uncharacterized protein. (151 aa)
MGG_03233ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (489 aa)
MGG_03204Replication factor C subunit 1. (1084 aa)
MGG_03202Replication factor C subunit 5. (352 aa)
MGG_03184AAA_16 domain-containing protein. (477 aa)
MGG_00691BRCT domain-containing protein. (373 aa)
MGG_00685Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
MGG_00630ATP-dependent DNA helicase srs2. (998 aa)
MGG_00597Hsk1-interacting molecule 1. (668 aa)
MGG_00519Vezatin domain-containing protein. (623 aa)
MGG_00518Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
MGG_00485DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1201 aa)
MGG_01089DNA polymerase iota. (625 aa)
MGG_01032BRCT domain-containing protein. (840 aa)
MGG_00213DNA replication complex GINS protein PSF3. (207 aa)
MGG_00881DNA primase; Belongs to the eukaryotic-type primase small subunit family. (529 aa)
MGG_00879DNA mismatch repair protein msh-2; Component of the post-replicative DNA mismatch repair system (MMR). (924 aa)
MGG_00868Global transactivator. (865 aa)
MGG_00841Exonuclease 1. (780 aa)
MGG_00169CBFD_NFYB_HMF domain-containing protein. (378 aa)
MGG_11498F-box domain-containing protein. (728 aa)
MGG_00706DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (666 aa)
MGG_00704DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1218 aa)
MGG_04208Uncharacterized protein. (296 aa)
MGG_04175DNA repair protein rad18. (430 aa)
MGG_08738MutS protein. (896 aa)
MGG_01917DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (247 aa)
MGG_17643Uncharacterized protein. (249 aa)
MGG_12138Checkpoint protein; Belongs to the HUS1 family. (371 aa)
MGG_03910Uncharacterized protein. (421 aa)
MGG_03854DNA ligase. (859 aa)
MGG_03850DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2240 aa)
MGG_17683DNA helicase; Belongs to the MCM family. (953 aa)
MGG_04127Uncharacterized protein. (452 aa)
MGG_04123Chromosome transmission fidelity protein 18. (1028 aa)
MGG_02656Protein kinase rad3; Belongs to the PI3/PI4-kinase family. (2462 aa)
MGG_02986DNA polymerase. (1782 aa)
MGCH7_ch7g688Sister chromatid cohesion protein Eso1. (668 aa)
RHM52DNA repair and recombination protein rhm52; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). Belongs to the RAD52 family. (555 aa)
Your Current Organism:
Pyricularia oryzae
NCBI taxonomy Id: 242507
Other names: Magnaporthe grisea 70-15, P. oryzae 70-15, Pyricularia oryzae 70-15
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