STRINGSTRING
FEN1 FEN1 TOF1 TOF1 CSM3 CSM3 MGG_13023 MGG_13023 MGG_08646 MGG_08646 MGG_06731 MGG_06731 MGG_06763 MGG_06763 MGG_05615 MGG_05615 MGG_06969 MGG_06969 MGG_09293 MGG_09293 MCM7 MCM7 MGG_02366 MGG_02366 MGG_02459 MGG_02459 MGG_02482 MGG_02482 MGG_04434 MGG_04434 MGG_11196 MGG_11196 MGG_01549 MGG_01549 MGG_01611 MGG_01611 MGG_01614 MGG_01614 MGG_07222 MGG_07222 MGG_07238 MGG_07238 MGG_01694 MGG_01694 MGG_01696 MGG_01696 MGG_01759 MGG_01759 MGG_15325 MGG_15325 MGG_01813 MGG_01813 MGG_08071 MGG_08071 MGG_08122 MGG_08122 MGG_04389 MGG_04389 MGG_04410 MGG_04410 MGG_07526 MGG_07526 MGG_09487 MGG_09487 MGG_05049 MGG_05049 MGG_12843 MGG_12843 MGG_06397 MGG_06397 MGG_06370 MGG_06370 MGG_03488 MGG_03488 MGG_03246 MGG_03246 MGG_03204 MGG_03204 MGG_03202 MGG_03202 MGG_03184 MGG_03184 MGG_00691 MGG_00691 MGG_00597 MGG_00597 MGG_00519 MGG_00519 MGG_00518 MGG_00518 MGG_00485 MGG_00485 MGG_01089 MGG_01089 MGG_00213 MGG_00213 MGG_00881 MGG_00881 MGG_00169 MGG_00169 MGG_11498 MGG_11498 MGG_00706 MGG_00706 MGG_01917 MGG_01917 MGG_03910 MGG_03910 MGG_03854 MGG_03854 MGG_03850 MGG_03850 MGG_17683 MGG_17683 MGG_04127 MGG_04127 MGG_04123 MGG_04123 MGG_02986 MGG_02986 MGCH7_ch7g688 MGCH7_ch7g688
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa)
TOF1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1214 aa)
CSM3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (357 aa)
MGG_13023Replication factor C subunit 3. (404 aa)
MGG_08646DNA helicase; Belongs to the MCM family. (720 aa)
MGG_06731Uncharacterized protein. (192 aa)
MGG_06763DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (506 aa)
MGG_05615Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (785 aa)
MGG_06969Minichromosome loss protein 1. (854 aa)
MGG_09293DNA helicase; Belongs to the MCM family. (1029 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (815 aa)
MGG_02366Uncharacterized protein. (1005 aa)
MGG_02459DNA polymerase delta small subunit. (497 aa)
MGG_02482DNA replication licensing factor mcm10. (838 aa)
MGG_04434DNA replication complex GINS protein PSF1. (215 aa)
MGG_11196Origin recognition complex subunit 4. (836 aa)
MGG_01549DNA replication initiation factor Cdc45. (871 aa)
MGG_01611DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
MGG_01614Cell division control protein; Belongs to the CDC6/cdc18 family. (598 aa)
MGG_07222DNA polymerase epsilon subunit B. (865 aa)
MGG_07238DNA polymerase kappa. (634 aa)
MGG_01694HORMA domain-containing protein. (454 aa)
MGG_01696Uncharacterized protein. (132 aa)
MGG_01759DNA helicase; Belongs to the MCM family. (896 aa)
MGG_15325CMGC/RCK/MAK protein kinase. (808 aa)
MGG_01813MRC1 domain-containing protein. (1407 aa)
MGG_08071DNA polymerase. (1103 aa)
MGG_08122DNA helicase; Belongs to the MCM family. (873 aa)
MGG_04389Replication factor C subunit 2. (384 aa)
MGG_04410Origin recognition complex subunit. (744 aa)
MGG_07526Replication factor C subunit 4. (358 aa)
MGG_09487Origin recognition complex subunit. (616 aa)
MGG_05049AAA domain-containing protein. (1266 aa)
MGG_12843RRM domain-containing protein. (323 aa)
MGG_06397DNA polymerase. (1482 aa)
MGG_06370DNA ligase. (896 aa)
MGG_03488CDC7 protein kinase. (497 aa)
MGG_03246Uncharacterized protein. (151 aa)
MGG_03204Replication factor C subunit 1. (1084 aa)
MGG_03202Replication factor C subunit 5. (352 aa)
MGG_03184AAA_16 domain-containing protein. (477 aa)
MGG_00691BRCT domain-containing protein. (373 aa)
MGG_00597Hsk1-interacting molecule 1. (668 aa)
MGG_00519Vezatin domain-containing protein. (623 aa)
MGG_00518Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
MGG_00485DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1201 aa)
MGG_01089DNA polymerase iota. (625 aa)
MGG_00213DNA replication complex GINS protein PSF3. (207 aa)
MGG_00881DNA primase; Belongs to the eukaryotic-type primase small subunit family. (529 aa)
MGG_00169CBFD_NFYB_HMF domain-containing protein. (378 aa)
MGG_11498F-box domain-containing protein. (728 aa)
MGG_00706DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (666 aa)
MGG_01917DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (247 aa)
MGG_03910Uncharacterized protein. (421 aa)
MGG_03854DNA ligase. (859 aa)
MGG_03850DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2240 aa)
MGG_17683DNA helicase; Belongs to the MCM family. (953 aa)
MGG_04127Uncharacterized protein. (452 aa)
MGG_04123Chromosome transmission fidelity protein 18. (1028 aa)
MGG_02986DNA polymerase. (1782 aa)
MGCH7_ch7g688Sister chromatid cohesion protein Eso1. (668 aa)
Your Current Organism:
Pyricularia oryzae
NCBI taxonomy Id: 242507
Other names: Magnaporthe grisea 70-15, P. oryzae 70-15, Pyricularia oryzae 70-15
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