40 items (Pyricularia oryzae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRS4	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity). (680 aa)
	PAN1	Actin cytoskeleton-regulatory complex protein PAN1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1462 aa)
	MGG_06649	EF hand domain-containing protein. (1300 aa)
	MGG_16334	Uncharacterized protein. (1095 aa)
	MGG_05456	CFEM domain-containing protein. (194 aa)
	MGG_05484	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (437 aa)
	MGG_05531	CFEM domain-containing protein. (173 aa)
	MGG_05534	BAR domain-containing protein. (468 aa)
	MGG_02049	Interferon-induced GTP-binding protein Mx2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (711 aa)
	MGG_06876	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (234 aa)
	MGG_11801	AP-1 complex subunit gamma. (845 aa)
	MGG_10633	AP-1 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (448 aa)
	MGG_02383	Uncharacterized protein. (287 aa)
	MGG_02434	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (187 aa)
	MGG_11902	Mitochondrial dynamin GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (966 aa)
	MGG_04616	Epsin-1. (587 aa)
	MGG_11326	NAK protein kinase. (1045 aa)
	MGG_01762	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (143 aa)
	MGG_01846	AP-3 complex beta3B subunit. (812 aa)
	MGG_15796	GED domain-containing protein. (109 aa)
	MGG_10448	ENTH domain-containing protein. (554 aa)
	MGG_08098	AP-3 adaptor complex subunit mu; Belongs to the adaptor complexes medium subunit family. (577 aa)
	MGG_15670	Uncharacterized protein. (289 aa)
	MGG_11227	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
	MGG_06216	Uncharacterized protein. (471 aa)
	MGG_09570	CFEM domain-containing protein. (321 aa)
	MGG_07768	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1680 aa)
	MGG_07481	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1033 aa)
	MGG_07490	Uncharacterized protein. (211 aa)
	MGG_09493	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (989 aa)
	MGG_04906	muHD domain-containing protein. (774 aa)
	MGG_06078	Adaptin ear-binding coat-associated protein 2. (277 aa)
	MGG_13514	ENTH domain-containing protein. (615 aa)
	MGG_03320	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (738 aa)
	MGG_17540	Uncharacterized protein. (399 aa)
	MGG_12178	Uncharacterized protein. (298 aa)
	MGG_04289	Dynamin GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (520 aa)
	MGG_04150	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (724 aa)
	MGG_04148	Rad60-SLD_2 domain-containing protein. (263 aa)
	MGG_02949	Cytoskeleton assembly control protein Sla2. (1048 aa)

Your Current Organism:

Pyricularia oryzae

NCBI taxonomy Id: 242507
Other names: Magnaporthe grisea 70-15, P. oryzae 70-15, Pyricularia oryzae 70-15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRS4	MGG_01762	A4QST9	G4MVD4	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.610
IRS4	MGG_03320	A4QST9	G4N974	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.415
IRS4	MGG_04148	A4QST9	G4NIR0	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	Rad60-SLD_2 domain-containing protein.	0.415
IRS4	MGG_04150	A4QST9	G4NIQ6	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.415
IRS4	MGG_04616	A4QST9	G4MSW7	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	Epsin-1.	0.535
IRS4	MGG_05484	A4QST9	G4MM57	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.575
IRS4	MGG_06078	A4QST9	G4N575	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	Adaptin ear-binding coat-associated protein 2.	0.484
IRS4	MGG_06876	A4QST9	G4MMW9	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.580
IRS4	MGG_07481	A4QST9	G4N1A2	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	0.486
IRS4	MGG_07768	A4QST9	G4N0Z8	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.621
IRS4	MGG_10448	A4QST9	G4MY15	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	ENTH domain-containing protein.	0.535
IRS4	MGG_11326	A4QST9	G4MV67	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	NAK protein kinase.	0.412
IRS4	MGG_11801	A4QST9	G4MMY1	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	AP-1 complex subunit gamma.	0.486
IRS4	MGG_13514	A4QST9	G4N7C0	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	ENTH domain-containing protein.	0.515
MGG_01762	IRS4	G4MVD4	A4QST9	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).	0.610
MGG_01762	MGG_03320	G4MVD4	G4N974	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.908
MGG_01762	MGG_04148	G4MVD4	G4NIR0	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Rad60-SLD_2 domain-containing protein.	0.908
MGG_01762	MGG_04150	G4MVD4	G4NIQ6	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.990
MGG_01762	MGG_04616	G4MVD4	G4MSW7	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Epsin-1.	0.705
MGG_01762	MGG_05484	G4MVD4	G4MM57	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.999