(37 nodes) Mitotic cell cycle phase transition network (Pyricularia oryzae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MGG_00338	Uncharacterized protein. (1151 aa)
	MGG_00136	HMG box domain-containing protein. (286 aa)
	MGG_11491	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1407 aa)
	MGG_00105	Uncharacterized protein. (2011 aa)
	MGG_00754	Uncharacterized protein. (291 aa)
	MGG_03911	Serine/threonine-protein phosphatase. (395 aa)
	MGG_09363	Uncharacterized protein. (610 aa)
	MGG_09869	Uncharacterized protein. (895 aa)
	MGG_12515	Uncharacterized protein. (935 aa)
	MGG_09912	CAMK/CAMK1 protein kinase; Belongs to the protein kinase superfamily. (406 aa)
	MGG_05646	G2/mitotic-specific cyclin-B; Belongs to the cyclin family. (494 aa)
	MGG_06726	Septin like spn2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (337 aa)
	MGG_08648	Anaphase-promoting complex subunit 8. (697 aa)
	MGG_14266	Ubiquitin-conjugating enzyme. (260 aa)
	STS1	Tethering factor for nuclear proteasome STS1; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity). (313 aa)
	HTZ1	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (142 aa)
	MGG_01082	PAPA-1 domain-containing protein. (424 aa)
	MGG_08463	Transcription factor MBP1. (715 aa)
	MGG_03314	Uncharacterized protein. (2081 aa)
	MGG_17195	Uncharacterized protein. (850 aa)
	MGG_03595	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (406 aa)
	MGG_16762	Uncharacterized protein; Belongs to the actin family. (771 aa)
	MGG_06094	DNA repair protein RAD5. (893 aa)
	MGG_06043	Histone deacetylase HOS3. (1141 aa)
	MGG_13435	Sulfur controller 2. (694 aa)
	MGG_07440	Anaphase-promoting complex subunit cut9. (664 aa)
	MGG_07734	M-phase inducer phosphatase. (569 aa)
	MGG_01362	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily. (320 aa)
	MGG_11047	DNA repair and recombination protein RAD5C. (802 aa)
	MGG_08844	RING-box protein 1. (119 aa)
	MGG_04724	Anaphase-promoting complex subunit 2; Belongs to the cullin family. (1043 aa)
	MGG_01543	JmjC domain-containing protein 5. (532 aa)
	MGG_04660	CMGC/CDK/CDK5 protein kinase; Belongs to the protein kinase superfamily. (350 aa)
	MGG_07155	Transcription termination factor 2. (1113 aa)
	MGG_07065	G2/mitotic-specific cyclin-B; Belongs to the cyclin family. (657 aa)
	MGG_04565	TPR domain-containing protein. (392 aa)
	MGG_09960	Serine/threonine-protein kinase. (1009 aa)

Your Current Organism:

Pyricularia oryzae

NCBI taxonomy Id: 242507
Other names: Magnaporthe grisea 70-15, P. oryzae 70-15, Pyricularia oryzae 70-15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HTZ1	MGG_00136	A4QVR2	G4NE82	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	HMG box domain-containing protein.	0.694
HTZ1	MGG_01362	A4QVR2	G4MZ20	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily.	0.430
HTZ1	MGG_03595	A4QVR2	G4N7D5	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family.	0.475
HTZ1	MGG_04660	A4QVR2	G4MTA2	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	CMGC/CDK/CDK5 protein kinase; Belongs to the protein kinase superfamily.	0.430
HTZ1	MGG_05646	A4QVR2	G4MNM0	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	G2/mitotic-specific cyclin-B; Belongs to the cyclin family.	0.545
HTZ1	MGG_06043	A4QVR2	G4N4X5	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	Histone deacetylase HOS3.	0.552
HTZ1	MGG_07065	A4QVR2	G4MSL8	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	G2/mitotic-specific cyclin-B; Belongs to the cyclin family.	0.545
HTZ1	MGG_09960	A4QVR2	G4MRN5	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	Serine/threonine-protein kinase.	0.732
HTZ1	MGG_11491	A4QVR2	G4NEB7	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.477
MGG_00136	HTZ1	G4NE82	A4QVR2	HMG box domain-containing protein.	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	0.694
MGG_00136	MGG_16762	G4NE82	G4N5J9	HMG box domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.788
MGG_00338	MGG_06094	G4NCX0	G4N594	Uncharacterized protein.	DNA repair protein RAD5.	0.419
MGG_00338	MGG_16762	G4NCX0	G4N5J9	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.512
MGG_00754	MGG_01082	G4NEN2	G4NCH4	Uncharacterized protein.	PAPA-1 domain-containing protein.	0.578
MGG_00754	MGG_16762	G4NEN2	G4N5J9	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.598
MGG_01082	MGG_00754	G4NCH4	G4NEN2	PAPA-1 domain-containing protein.	Uncharacterized protein.	0.578
MGG_01082	MGG_16762	G4NCH4	G4N5J9	PAPA-1 domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.532
MGG_01362	HTZ1	G4MZ20	A4QVR2	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily.	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]	0.430
MGG_01362	MGG_03314	G4MZ20	G4N983	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.883
MGG_01362	MGG_03595	G4MZ20	G4N7D5	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily.	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family.	0.811