(47 nodes) DEAD/DEAH box helicase domain network (Pyricularia oryzae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	MGG_16579	Uncharacterized protein. (1283 aa)
	DBP4	ATP-dependent RNA helicase DBP4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (798 aa)
	DED1	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (671 aa)
	DCL2	ATP-dependent helicase DCL2; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Belongs to the helicase family. Dicer subfamily. (1485 aa)
	DBP5	ATP-dependent RNA helicase DBP5; ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity). (477 aa)
	PRP28	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (674 aa)
	ROK1	ATP-dependent RNA helicase ROK1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (775 aa)
	PRP5	Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1012 aa)
	MGG_15295	Uncharacterized protein. (963 aa)
	MAK5	ATP-dependent RNA helicase MAK5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. (760 aa)
	MGG_05700	RecQ helicase MUSN. (1780 aa)
	MGG_15042	Antiviral helicase SKI2. (1305 aa)
	DBP2	ATP-dependent RNA helicase DBP2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (548 aa)
	MRH4	ATP-dependent RNA helicase MRH4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily. (651 aa)
	DBP9	ATP-dependent RNA helicase DBP9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (636 aa)
	FAL1	ATP-dependent RNA helicase FAL1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. (401 aa)
	TIF1	ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (396 aa)
	DBP7	ATP-dependent RNA helicase DBP7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (825 aa)
	DRS1	ATP-dependent RNA helicase DRS1; ATP-binding RNA helicase involved in ribosome assembly. (790 aa)
	DBP10	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (914 aa)
	DHH1	ATP-dependent RNA helicase DHH1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (535 aa)
	RRP3	ATP-dependent rRNA helicase RRP3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA. (538 aa)
	HAS1	ATP-dependent RNA helicase HAS1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (587 aa)
	DBP8	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (579 aa)
	SUB2	ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (436 aa)
	MGCH7_ch7g509	ATP-dependent RNA helicase DED1; Belongs to the DEAD box helicase family. (619 aa)
	MGG_10312	Uncharacterized protein; Belongs to the DEAD box helicase family. (580 aa)
	MGG_17846	Uncharacterized protein. (1433 aa)
	MGG_03893	Pre-mRNA-splicing factor ATP-dependent RNA helicase prp43. (779 aa)
	MGG_03931	FRQ-interacting RNA helicase. (1102 aa)
	MGG_04040	DEAH box polypeptide 37. (1185 aa)
	MGG_08807	Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22. (1207 aa)
	MGG_03229	ATP-dependent RNA helicase dbp6. (896 aa)
	MGG_03233	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (489 aa)
	MGG_16997	Uncharacterized protein. (1140 aa)
	MGG_06124	Activating signal cointegrator 1 complex subunit 3. (1998 aa)
	MGG_13223	Uncharacterized protein. (1165 aa)
	MGG_05900	Uncharacterized protein. (1508 aa)
	MGG_16993	Uncharacterized protein. (1283 aa)
	MGG_07501	ATP-dependent RNA helicase DHX8. (1016 aa)
	MGG_07059	Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22. (1404 aa)
	MGG_15536	Uncharacterized protein. (2216 aa)
	MGG_07250	DEAD/DEAH box helicase. (1771 aa)
	MGG_11351	Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16. (999 aa)
	MGG_07099	Uncharacterized protein; Belongs to the DEAD box helicase family. (717 aa)
	MGG_02417	RNA helicase. (636 aa)
	MGG_04709	Uncharacterized protein. (1504 aa)

Your Current Organism:

Pyricularia oryzae

NCBI taxonomy Id: 242507
Other names: Magnaporthe grisea 70-15, P. oryzae 70-15, Pyricularia oryzae 70-15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DBP10	DBP2	A4R5B8	A4QSS5	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase DBP2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.	0.605
DBP10	DBP4	A4R5B8	A4RGU2	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase DBP4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).	0.874
DBP10	DBP7	A4R5B8	A4QX49	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase DBP7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.	0.697
DBP10	DBP8	A4R5B8	A4R8G3	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	0.684
DBP10	DBP9	A4R5B8	A4QTR1	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase DBP9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.	0.863
DBP10	DRS1	A4R5B8	A4QYM6	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase DRS1; ATP-binding RNA helicase involved in ribosome assembly.	0.713
DBP10	FAL1	A4R5B8	A4QU31	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase FAL1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.	0.419
DBP10	HAS1	A4R5B8	A4R8B5	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase HAS1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.	0.863
DBP10	MAK5	A4R5B8	A4REU9	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase MAK5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.	0.889
DBP10	MGG_02417	A4R5B8	G4MRG4	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	RNA helicase.	0.809
DBP10	MGG_03229	A4R5B8	G4N9X9	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase dbp6.	0.628
DBP10	MGG_03893	A4R5B8	G4NHA6	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	Pre-mRNA-splicing factor ATP-dependent RNA helicase prp43.	0.764
DBP10	MGG_03931	A4R5B8	G4NH56	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	FRQ-interacting RNA helicase.	0.816
DBP10	MGG_04040	A4R5B8	G4NGS5	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	DEAH box polypeptide 37.	0.825
DBP10	MGG_07099	A4R5B8	G4MSR4	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.574
DBP10	MGG_07501	A4R5B8	G4N1N4	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase DHX8.	0.429
DBP10	MGG_08807	A4R5B8	G4NFJ0	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22.	0.589
DBP10	MGG_10312	A4R5B8	G4NK05	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.555
DBP10	ROK1	A4R5B8	A4RMV8	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent RNA helicase ROK1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.	0.893
DBP10	RRP3	A4R5B8	A4RGD1	ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	ATP-dependent rRNA helicase RRP3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.	0.703