(23 nodes) Mismatch repair network (Pyricularia oryzae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	MSH3	DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1151 aa)
	MGG_13023	Replication factor C subunit 3. (404 aa)
	MGG_06731	Uncharacterized protein. (192 aa)
	MGG_02459	DNA polymerase delta small subunit. (497 aa)
	MGG_07121	DNA mismatch repair protein mutL. (690 aa)
	MGG_07124	Replication protein A 32 kDa subunit. (275 aa)
	MGG_15760	Uncharacterized protein. (1107 aa)
	MGG_08071	DNA polymerase. (1103 aa)
	MGG_04389	Replication factor C subunit 2. (384 aa)
	MGG_07526	Replication factor C subunit 4. (358 aa)
	MGG_06370	DNA ligase. (896 aa)
	MGG_03284	DNA mismatch repair protein. (947 aa)
	MGG_03204	Replication factor C subunit 1. (1084 aa)
	MGG_03202	Replication factor C subunit 5. (352 aa)
	MGG_00685	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
	MGG_00630	ATP-dependent DNA helicase srs2. (998 aa)
	MGG_00518	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
	MGG_00879	DNA mismatch repair protein msh-2; Component of the post-replicative DNA mismatch repair system (MMR). (924 aa)
	MGG_00841	Exonuclease 1. (780 aa)
	MGG_00704	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1218 aa)
	MGG_04010	Uncharacterized protein. (113 aa)
	MGG_03854	DNA ligase. (859 aa)
	MGG_04127	Uncharacterized protein. (452 aa)

Your Current Organism:

Pyricularia oryzae

NCBI taxonomy Id: 242507
Other names: Magnaporthe grisea 70-15, P. oryzae 70-15, Pyricularia oryzae 70-15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MGG_00518	MGG_00630	G4NBP7	G4NB43	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	ATP-dependent DNA helicase srs2.	0.873
MGG_00518	MGG_00685	G4NBP7	G4NAX8	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.914
MGG_00518	MGG_00704	G4NBP7	G4NEZ2	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.964
MGG_00518	MGG_00841	G4NBP7	G4NE19	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Exonuclease 1.	0.908
MGG_00518	MGG_00879	G4NBP7	G4NDR8	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA mismatch repair protein msh-2; Component of the post-replicative DNA mismatch repair system (MMR).	0.918
MGG_00518	MGG_02459	G4NBP7	G4MRX2	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase delta small subunit.	0.954
MGG_00518	MGG_03202	G4NBP7	G4NAB7	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C subunit 5.	0.967
MGG_00518	MGG_03204	G4NBP7	G4NAB5	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C subunit 1.	0.943
MGG_00518	MGG_03284	G4NBP7	G4N9G6	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA mismatch repair protein.	0.577
MGG_00518	MGG_03854	G4NBP7	G4NHG0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA ligase.	0.925
MGG_00518	MGG_04127	G4NBP7	G4NIT0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.856
MGG_00518	MGG_04389	G4NBP7	G4MZE2	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C subunit 2.	0.979
MGG_00518	MGG_06370	G4NBP7	G4N7T1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA ligase.	0.948
MGG_00518	MGG_07121	G4NBP7	G4MT39	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA mismatch repair protein mutL.	0.814
MGG_00518	MGG_07124	G4NBP7	G4MT45	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication protein A 32 kDa subunit.	0.884
MGG_00518	MGG_07526	G4NBP7	G4N1R0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C subunit 4.	0.963
MGG_00518	MGG_08071	G4NBP7	G4MXT0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase.	0.952
MGG_00518	MGG_13023	G4NBP7	G4MKW4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C subunit 3.	0.950
MGG_00518	MGG_15760	G4NBP7	G4MV84	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.775
MGG_00518	MSH3	G4NBP7	A4R0R0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...]	0.840