STRINGSTRING
ask ask hisF hisF trpC trpC eIF-2B eIF-2B trpB trpB argH argH thrC thrC dapB dapB hisI hisI proB proB ilvD-2 ilvD-2 carB carB aroG aroG leuB leuB leuA leuA leuD leuD leuA-2 leuA-2 RB12905 RB12905 leuA-3 leuA-3 asnB asnB hisD hisD aroB aroB aroA-2 aroA-2 argC argC dapA dapA argJ argJ aroK aroK proC proC trpD trpD asnB-2 asnB-2 ilvA ilvA carA carA trpA trpA hisI-2 hisI-2 hisG hisG argB argB argF argF glyA glyA serC serC serA-2 serA-2 RB6292 RB6292 aroD aroD aroC aroC proA proA folD folD hisC hisC hisBD hisBD trpE trpE hisA hisA ilvE-2 ilvE-2 metX metX argG argG hom hom aroH aroH trpF trpF hisH hisH asd asd metH metH ilvC ilvC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
askProbable aspartokinase; PMID: 7910936 best DB hits: BLAST: pir:S76764; hypothetical protein - Synechocystis sp. (strain PCC; E=2e-96 pir:T35383; probable aspartokinase - Streptomyces coelicolor -----; E=4e-92 swissprot:P41403; AK_MYCSM ASPARTOKINASE (ASPARTATE KINASE); E=7e-90 COG: slr0657; COG0527 Aspartokinases; E=2e-97 PFAM: PF00696; Amino acid kinase family; E=4.9e-68 PF01842; ACT domain; E=6.2e-08. (595 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (262 aa)
trpCIndole-3-glycerol phosphate synthase; PMID: 1896020 PMID: 7007653 PMID: 6355484 best DB hits: BLAST: swissprot:P26938; TRPC_AZOBR INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=6e-55 swissprot:P94327; TRPC_BRAJA INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=3e-52 swissprot:Q9ZFA7; TRPC_RHOSH INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=2e-51 COG: XF0213; COG0134 Indole-3-glycerol phosphate synthase; E=5e-51 PFAM: PF00218; Indole-3-glycerol phosphate synthase; E=2.6e-111; Belongs to the TrpC family. (259 aa)
eIF-2BPutative translation initiation factor eIF-2B; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (356 aa)
trpBTryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa)
argHArgininosuccinate lyase; PMID: 2121708 PMID: 10984043 best DB hits: BLAST: pir:B81175; argininosuccinate lyase NMB0637 [imported] - Neisseria; E=1e-110 pir:C81930; probable argininosuccinate lyase (EC 4.3.2.1) NMA0847; E=1e-110 swissprot:P50987; ARLY_PSEAE ARGININOSUCCINATE LYASE; E=1e-107 COG: NMB0637; COG0165 Argininosuccinate lyase; E=1e-111 PAB0829; COG0015 Adenylosuccinate lyase; E=5e-14 PFAM: PF00206; Lyase; E=3.2e-82. (660 aa)
thrCThreonine synthase precursor; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (456 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (280 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (126 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (389 aa)
ilvD-2Dihydroxy-acid dehydratase; PMID: 8325851 PMID: 7771772 best DB hits: BLAST: ddbj:BAB03011.1; (AP001297) dihydroxy-acid dehydratase; E=0.0 swissprot:Q10318; ILV3_SCHPO PUTATIVE DIHYDROXY-ACID DEHYDRATASE,; E=0.0 embl:CAA89540.1; (Z49516) ORF YJR016c [Saccharomyces cerevisiae]; E=1e-170 COG: YJR016c; COG0129 Dihydroxyacid dehydratase/phosphogluconate; E=1e-171 ilvD; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; E=7e-81 PA0353; COG0129 Dihydroxyacid dehydratase/phosphogluconate; E=4e-80 PFAM: PF00391; PEP-utilizing enzyme, mobile do; E=0.48 PF00920; Dehydratase family; [...] (587 aa)
carBPMID: 8905231 PMID: 6308632 best DB hits: BLAST: swissprot:P00968; CARB_ECOLI CARBAMOYL-PHOSPHATE SYNTHASE LARGE; E=0.0 pir:S76557; carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC; E=0.0 gb:AAG10606.1; AC008030_6 (AC008030) carbamoyl phosphate synthetase; E=0.0 COG: AF1274; COG0458 Carbamoylphosphate synthase large subunit (split gene; E=0.0 carB; COG0458 Carbamoylphosphate synthase large subunit (split gene in; E=0.0 BU144; COG0458 Carbamoylphosphate synthase large subunit (split gene; E=0.0 PFAM: PF00289; Carbamoyl-phosphate synthase L; E=2.9e-53 PF02222; ATP-grasp domain; E [...] (1083 aa)
aroGPhospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (375 aa)
leuA3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (511 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (562 aa)
RB12905Acetolactate synthase III [Precursor]; PMID: 1896019 best DB hits: BLAST: swissprot:P27819; ILV3_BRANA ACETOLACTATE SYNTHASE III,; E=1e-167 swissprot:P27818; ILV1_BRANA ACETOLACTATE SYNTHASE I, CHLOROPLAST; E=1e-167 pir:S15004; acetolactate synthase (EC 4.1.3.18) 2 precursor - rape; E=1e-167 COG: AF1720; COG0028 Thiamine pyrophosphate-requiring enzymes; E=1e-129 ilvG; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate; E=1e-123 slr2088; COG0028 Thiamine pyrophosphate-requiring enzymes; E=1e-121 PFAM: PF02776; Thiamine pyrophosphate enzyme,; E=9.8e-87 PF00205; Thiamine pyrop [...] (619 aa)
leuA-32-isopropylmalate synthase; PMID: 6171647 best DB hits: BLAST: swissprot:O66682; LY41_AQUAE PUTATIVE LYASE AQ_356 ----- pir:; E=1e-132 pir:E75045; 2-isopropylmalate synthase (leua-3) PAB0894 - Pyrococcus; E=1e-130 swissprot:Q9WZ22; LY41_THEMA PUTATIVE LYASE TM0552 ----- pir:; E=1e-124 COG: aq_356; COG0119 Isopropylmalate/homocitrate/citramalate synthases; E=1e-133 PFAM: PF00682; HMGL-like; E=6.6e-09; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa)
asnBAsparagine synthetase; PMID: 10498721 best DB hits: BLAST: gb:AAG02363.1; AF210249_22 (AF210249) asparagine synthetase; E=1e-57 swissprot:P54420; ASNB_BACSU ASPARAGINE SYNTHETASE; E=3e-50 ddbj:BAB05227.1; (AP001512) asparagine synthetase [Bacillus; E=4e-49 COG: BS_asnB; COG0367 Asparagine synthase (glutamine-hydrolyzing); E=2e-51 PFAM: PF00310; Glutamine amidotransferases clas; E=4.1e-15 PF00733; Asparagine synthase; E=1.6e-13. (639 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (460 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (428 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (501 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (314 aa)
argJArginine biosynthesis bifunctional protein argJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (410 aa)
aroKShikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (187 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa)
asnB-2Asparagine synthetase [glutamine-hydrolyzing] 1; PMID: 10498721 PMID: 8755891 best DB hits: BLAST: gb:AAF34252.1; AF168003_7 (AF168003) putative asparagine; E=1e-100 gb:AAF24002.1; (AF035937) WbpS [Pseudomonas aeruginosa]; E=9e-94 ddbj:BAA33606.1; (AB012956) probable asparagine synthetase; E=1e-89 COG: BS_asnB; COG0367 Asparagine synthase (glutamine-hydrolyzing); E=2e-86 PFAM: PF00310; Glutamine amidotransferases clas; E=5.6e-21 PF00733; Asparagine synthase; E=1.5e-51. (634 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa)
carACarbamoyl-phosphate synthase, small chain; PMID: 2843375 PMID: 6330744 best DB hits: BLAST: pir:E82083; carbamoyl-phosphate synthase, small chain VC2390; E=1e-99 pir:C70337; carbamoyl phosphate synthetase small subunit - Aquifex; E=3e-98 pir:S76783; hypothetical protein - Synechocystis sp. (strain PCC; E=6e-96 COG: VC2390; COG0505 Carbamoylphosphate synthase small subunit; E=1e-100 PFAM: PF00988; Carbamoyl-phosphate synthase; E=8.7e-82 PF00117; Glutamine amidotransferase cl; E=5.7e-62; Belongs to the CarA family. (389 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (293 aa)
hisI-2Probable phosphoribosyl-ATP pyrophosphatase; PMID: 3062174 best DB hits: BLAST: swissprot:O30723; HIS2_RHOCA PHOSPHORIBOSYL-ATP PYROPHOSPHATASE; E=2e-10 swissprot:P26722; HIS2_AZOBR PHOSPHORIBOSYL-ATP PYROPHOSPHATASE; E=6e-08 pir:D81178; phosphoribosyl-ATP cyclohydrolase NMB0603 [imported] -; E=8e-08 COG: NMB0603; COG0140 Phosphoribosyl-ATP pyrophosphohydrolase; E=8e-09 PFAM: PF01503; Phosphoribosyl-ATP pyrophosphohydrol; E=9.2e-30. (158 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (299 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (287 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (313 aa)
glyASerine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (383 aa)
serA-2Phosphoglycerate dehydrogenase; Best DB hits: BLAST: gb:AAB90429.1; (AE001048) phosphoglycerate dehydrogenase (serA); E=2e-97 ddbj:BAB05321.1; (AP001512) D-3-phosphoglycerate dehydrogenase; E=2e-94 swissprot:P73821; SERA_SYNY3 D-3-PHOSPHOGLYCERATE DEHYDROGENASE; E=2e-92 COG: AF0813; COG0111 Phosphoglycerate dehydrogenase and related; E=2e-98 PFAM: PF00389; D-isomer specific 2-hydroxyacid; E=5.3e-11 PF01408; Oxidoreductase family, NAD-bindi; E=0.15 PF02826; D-isomer specific 2-hydroxyacid; E=1.2e-88. (540 aa)
RB6292Conserved hypothetical protein; PMID: 8688087 best DB hits: BLAST: swissprot:Q58114; Y703_METJA HYPOTHETICAL PROTEIN MJ0703 -----; E=9e-14 gb:AAG32955.1; (AF032114) unknown [Methylobacterium extorquens]; E=6e-07 pir:A69189; phosphoribosylformimino-5-aminoimidazole carboxamide; E=4e-05 COG: MJ0703; COG1411 Archaeal family of HisA paralogs; E=9e-15; Belongs to the HisA/HisF family. (272 aa)
aroD3-dehydroquinate dehydratase / shikimate 5-dehydrogenase precursor; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Belongs to the type-I 3-dehydroquinase family. (496 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (404 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (434 aa)
folD5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (327 aa)
hisCHistidinol-phosphate aminotransferase; PMID: 1400209 best DB hits: BLAST: swissprot:P73807; HIS8_SYNY3 HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; E=1e-56 swissprot:P45358; HIS8_ACEXY HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; E=2e-52 gb:AAK00147.1; AF222753_2 (AF222753) putative aminotransferase; E=2e-43 COG: sll1958; COG0079 Histidinol-phosphate aminotransferase/Tyrosine; E=1e-57 PFAM: PF00155; Aminotransferase class-I; E=5.1e-06 PF00222; Aminotransferase class-II; E=1.3e-17; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase s [...] (362 aa)
hisBDBest DB hits: BLAST: ddbj:BAB07300.1; (AP001519) imidazoleglycerol-phosphate; E=3e-49 swissprot:O33564; HIS7_RHOSH IMIDAZOLEGLYCEROL-PHOSPHATE; E=1e-48 swissprot:P34047; HIS7_ARATH IMIDAZOLEGLYCEROL-PHOSPHATE; E=2e-48 COG: BH3581; COG0131 Imidazoleglycerol-phosphate dehydratase; E=3e-50 PFAM: PF00475; Imidazoleglycerol-phosphate dehydrat; E=7e-96. (202 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (547 aa)
hisAPMID: 2664449 best DB hits: BLAST: swissprot:P74561; HIS4_SYNY3; E=3e-56 pir:A83003; phosphoribosylformimino-5-aminoimidazole carboxamide; E=5e-49 gb:AAF05093.1; AF150930_2 (AF150930) phosphoribosyl; E=2e-46 COG: slr0652; COG0106 Phosphoribosylformimino-5-aminoimidazole; E=3e-57 PA5141; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide; E=5e-50 NMB0629; COG0106 Phosphoribosylformimino-5-aminoimidazole; E=6e-44 PFAM: PF00977; Histidine biosynthesis protein; E=4.7e-70. (253 aa)
ilvE-2Putative branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (285 aa)
metXHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; In the C-terminal section; belongs to the MetW family. (623 aa)
argGArgininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190. (444 aa)
homHomoserine dehydrogenase; PMID: 1333566 best DB hits: BLAST: pir:F69031; homoserine dehydrogenase (EC 1.1.1.3) - Methanobacterium; E=4e-81 gb:AAF21129.1; L78665_3 (L78665) homoserine dehydrogenase; E=2e-80 swissprot:P29365; DHOM_PSEAE HOMOSERINE DEHYDROGENASE (HDH); E=1e-77 COG: MTH1232; COG0460 Homoserine dehydrogenase; E=4e-82 PFAM: PF02737; 3-hydroxyacyl-CoA dehydrogenase; E=0.85 PF02254; KTN NAD-binding domain; E=0.19 PF01408; Oxidoreductase family, NAD-bind; E=0.73. (448 aa)
aroHChorismate mutase; PMID: 2105742 PMID: 8046752 best DB hits: BLAST: ddbj:BAB05377.1; (AP001512) chorismate mutase [Bacillus; E=6e-26 gb:AAD33790.1; AF139534_1 (AF139534) chorismate mutase [Bacillus; E=5e-25 swissprot:P19080; CHMU_BACSU CHORISMATE MUTASE (CM) ----- pir:; E=1e-22. (157 aa)
trpFN-(5-phosphoribosyl)anthranilate isomerase; PMID: 96003619 PMID: 97309356 best DB hits: BLAST: pdb:1DL3; A Chain A, Crystal Structure Of Mutually Generated; E=2e-19 swissprot:Q56320; TRPF_THEMA N-(5'-PHOSPHORIBOSYL)ANTHRANILATE; E=5e-19 pir:E81935; probable phosphoribosylanthranilate isomerase (EC; E=6e-18 COG: TM0139; COG0135 Phosphoribosylanthranilate isomerase; E=5e-20 PFAM: PF00697; N-(5'phosphoribosyl)anthranilate (PR; E=7.3e-41; Belongs to the TrpF family. (245 aa)
hisHAmidotransferase hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1246 aa)
ilvCAcetohydroxy acid isomeroreductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.