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| | aroD | 3-dehydroquinate dehydratase / shikimate 5-dehydrogenase precursor; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Belongs to the type-I 3-dehydroquinase family. (496 aa) |
| | metB-2 | Cystathionine gamma-lyase homolog; PMID: 9843488 best DB hits: BLAST: pir:T45483; cystathionine gamma-lyase homolog [imported] -; E=9e-93 pir:F83595; probable cystathionine gamma-lyase PA0400 [imported] -; E=1e-92 gb:AAG19548.1; (AE005045) cystathionine alpha synthase; MetB; E=3e-92 COG: PA0400; COG0626 Cystathionine beta-lyases/cystathionine; E=1e-93 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=2.9e-199. (397 aa) |
| | metB | Cystathionine gamma-synthase; PMID: 9002610 best DB hits: BLAST: embl:CAA64383.1; (X94756) cystathionine gamma-synthase; E=2e-75 gb:AAF26162.1; AC008261_19 (AC008261) putative cystathionine; E=2e-75 swissprot:P55217; METB_ARATH CYSTATHIONINE GAMMA-SYNTHASE,; E=3e-75 COG: APE1226; COG0626 Cystathionine beta-lyases/cystathionine; E=1e-64 PA5025; COG2873 O-acetylhomoserine sulfhydrylase; E=4e-47 PH1093; COG0626 Cystathionine beta-lyases/cystathionine; E=5e-47 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=4.5e-154. (434 aa) |
| | trpG-2 | Best DB hits: BLAST: swissprot:P20576; TRPG_PSEAE ANTHRANILATE SYNTHASE COMPONENT II; E=1e-60 pir:A35114; trpG protein - Pseudomonas aeruginosa ----- gb:; E=1e-60 pir:NNPS2P; anthranilate synthase (EC 4.1.3.27) component II; E=2e-59 COG: PA0649; COG0512 Anthranilate/para-aminobenzoate synthases component; E=1e-61 pabA; COG0512 Anthranilate/para-aminobenzoate synthases component II; E=3e-56 BS_pabA; COG0512 Anthranilate/para-aminobenzoate synthases component; E=2e-55 PFAM: PF00117; Glutamine amidotransferase class-I; E=2.5e-68. (208 aa) |
| | aroB-2 | 3-dehydroquinate synthase; PMID: 10910347 best DB hits: BLAST: pir:C82693; 3-dehydroquinate synthase XF1334 [imported] - Xylella; E=7e-24 swissprot:P34002; AROB_PSEAE 3-DEHYDROQUINATE SYNTHASE -----; E=1e-21 ddbj:BAB10417.1; (AB011474) 3-dehydroquinate synthase-like; E=6e-21 COG: XF1334; COG0337 3-dehydroquinate synthetase; E=6e-25 PFAM: PF01761; 3-dehydroquinate synthase; E=2.9e-29. (394 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit (air carboxylase) (airc); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (406 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (156 aa) |
| | cya | Probable adenylate cyclase; PMID: 1970565 best DB hits: BLAST: swissprot:P40137; CYAA_STIAU ADENYLATE CYCLASE 1 (ATP; E=9e-11 swissprot:P19485; CYA1_RHIME ADENYLATE CYCLASE 1 (ATP; E=2e-10 pir:C71320; probable adenylate cyclase - syphilis spirochete -----; E=3e-10 COG: TP0485; COG2114 Adenylate cyclase, family 3 (some proteins contain; E=2e-11 PFAM: PF00498; FHA domain; E=0.61 PF00211; Adenylate and Guanylate cyclase; E=1.1e-07. (702 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (293 aa) |
| | RB5319 | Best DB hits: BLAST: gb:AAB90381.1; (AE001045) D-arabino 3-hexulose 6-phosphate; E=1e-33 pir:B71209; probable D-arabino 3-hexulose 6-phosphate formaldehyde; E=8e-33 pir:C75022; d-arabino 3-hexulose 6-phosphate formaldehyde lyase; E=7e-28 COG: AF0861_1; COG0269 3-hexulose-6-phosphate synthase and related; E=1e-33 sgaH; COG0269 3-hexulose-6-phosphate synthase and related proteins; E=4e-10 VCA0242; COG0269 3-hexulose-6-phosphate synthase and related; E=3e-09 PFAM: PF00834; Ribulose-phosphate 3 epimerase; E=0.56 PF02581; Thiamine monophosphate synthas; E=0.01. (230 aa) |
| | RB5316 | Pectate lyase; PMID: 8955401 PMID: 1983191 best DB hits: BLAST: pir:JC6502; pectate lyase (EC 4.2.2.2) - Amycolata sp -----gb:; E=6e-30 pir:D72376; pectate lyase - Thermotoga maritima (strain MSB8); E=1e-26 ddbj:BAA96477.1; (AB041769) pectate lyase Pel-4A [Bacillus sp; E=3e-25 PFAM: PF00544; Pectate lyase; E=8.6e-31. (353 aa) |
| | pel | Pectate lyase; PMID: 8955401 PMID: 9427544 best DB hits: BLAST: embl:CAA65785.1; (X97119) pectate lyase [Erwinia chrysanthemi]; E=5e-29 pir:JC6502; pectate lyase (EC 4.2.2.2) - Amycolata sp ----- gb:; E=0.026 gb:AAF23285.1; AC016661_10 (AC016661) putative pectate lyase; E=0.037. (455 aa) |
| | dapA-3 | Probable dihydrodipicolinate synthase; PMID: 1463470 best DB hits: BLAST: pir:D81141; dihydrodipicolinate synthase NMB0929 [imported] -; E=3e-09 pir:H81878; probable dihydrodipicolinate synthase (EC 4.2.1.52); E=4e-09 ddbj:BAB05461.1; (AP001513) dihydrodipicolinate synthase; E=1e-07 COG: NMB0929; COG0329 Dihydrodipicolinate synthetase/N-acetylneuraminate; E=3e-10 PFAM: PF01137; RNA 3'-terminal phosphate cyclase; E=0.88 PF00701; Dihydrodipicolinate synthetase famil; E=0.00018; Belongs to the DapA family. (323 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa) |
| | RB5135 | 6-pyruvoyl tetrahydrobiopterin synthase; Best DB hits: BLAST: swissprot:Q9ZDY5; Y178_RICPR HYPOTHETICAL PROTEIN RP178 -----; E=2e-23 pir:E81913; hypothetical protein NMA0704 [imported] - Neisseria; E=3e-12 pir:G81189; 6-pyruvoyl tetrahydrobiopterin synthase, probable; E=7e-12 COG: RP178; COG0720 6-pyruvoyl-tetrahydropterin synthase; E=2e-24 PFAM: PF01242; 6-pyruvoyl tetrahydropterin synthase; E=1.2e-09. (137 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa) |
| | RB4958 | Similar to adenylate cyclase; PMID: 9171404 best DB hits: BLAST: ddbj:BAA14001.1; (D89626) adenylate cyclase [Anabaena sp.]; E=0.018 pir:S75331; penicillin-binding protein 1B mrcB - Synechocystis sp; E=0.10 ddbj:BAB11326.1; (AB016886) gene_id:MCA23.11~unknown protein; E=0.14 COG: slr1710; COG0744 Membrane carboxypeptidase (penicillin-binding; E=0.010 PFAM: PF02590; Uncharacterized ACR, COG1576; E=0.23 PF00498; FHA domain; E=1.6e-09. (250 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (937 aa) |
| | RB4903 | Phosphoketolase; Best DB hits: BLAST: pir:S76896; hypothetical protein - Synechocystis sp. (strain PCC; E=0.0 gb:AAK05600.1; AE006381_1 (AE006381) phosphoketolase [Lactococcus; E=0.0 embl:CAB62746.1; (AL133424) hypothetical protein SCF56.01c; E=0.0 COG: slr0453; COG0021 Transketolase; E=0.0. (793 aa) |
| | fbaB | Fructose-bisphosphate aldolase class I; PMID: 9531482 best DB hits: BLAST: pir:H64976; hypothetical protein b2097 - Escherichia coli (strain; E=1e-119 swissprot:P71295; ALF1_ECOLI FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS; E=1e-119 gb:AAB18249.1; (U73760) dehydrin [Escherichia coli]; E=1e-117 COG: fbaB; COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and; E=1e-120. (366 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; PMID: 8098035 PMID: 7853400 PMID: 8081752 best DB hits: BLAST: swissprot:Q07607; MOSA_RHIME MOSA PROTEIN ----- pir: B53308; E=2e-29 embl:CAC24079.1; (AL512981) ORF-c25_010 [Sulfolobus solfataricus]; E=7e-29 pir:S56523; dihydrodipicolinate synthase homolog yjhH - Escherichia; E=1e-28 COG: yjhH; COG0329 Dihydrodipicolinate synthetase/N-acetylneuraminate; E=1e-29 PFAM: PF00701; Dihydrodipicolinate synthetase famil; E=2.2e-57. (327 aa) |
| | RB4517 | Probable pterin-4-alpha-carbinolamine dehydratase; PMID: 8108417 PMID: 97052967 best DB hits: BLAST: pir:C70304; 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96); E=2e-10 ddbj:BAA97373.1; (AB023044) gene_id:MWD22.5~similar to unknown; E=5e-10 swissprot:P43335; PHS_PSEAE PTERIN-4-ALPHA-CARBINOLAMINE; E=4e-09 COG: aq_049; COG2154 Pterin-4a-carbinolamine dehydratase; E=2e-11 PFAM: PF01329; Pterin 4 alpha carbinolamine dehydr; E=1.2e-18. (117 aa) |
| | RB4386 | Cysteine synthase; PMID: 93345669 best DB hits: BLAST: swissprot:Q44004; CYSM_ALCEU CYSTEINE SYNTHASE (O-ACETYLSERINE; E=2e-35 pir:T43792; cysteine synthase (EC 4.2.99.8) cysK [similarity] -; E=1e-31 pir:H81161; probable cysteine synthase (EC 4.2.99.8) NMA0974; E=3e-31 COG: NMB0763; COG0031 Cysteine synthase; E=2e-32 PFAM: PF00291; Pyridoxal-phosphate dependent enzyme; E=9.2e-57. (349 aa) |
| | RB4382 | Probable diaminopimelate decarboxylase; PMID: 6350601 PMID: 89056708 PMID: 94237165 best DB hits: BLAST: swissprot:P55709; Y4YA_RHISN HYPOTHETICAL 49.9 KD PROTEIN Y4YA; E=3e-40 gb:AAG45731.1; AF229441_2 (AF229441) y4yA [Sinorhizobium fredii]; E=3e-40 gb:AAG45729.1; AF229440_2 (AF229440) y4yA [Sinorhizobium fredii]; E=3e-33 COG: aq_728; COG0019 Diaminopimelate decarboxylase; E=7e-08 PA4839; COG1166 Arginine decarboxylase (spermidine biosynthesis); E=5e-05 XF1116_2; COG0019 Diaminopimelate decarboxylase; E=5e-05 PFAM: PF02784; Pyridoxal-dependent decarboxyla; E=5.9e-08. (555 aa) |
| | RB4267 | A-type carbonic anhydrase; PMID: 11065374 best DB hits: BLAST: ddbj:BAA82053.1; (AB022175) a-type carbonic anhydrase; E=2e-20 pir:F82479; carbonic anhydrase VCA0274 [imported] - Vibrio cholerae; E=6e-18 swissprot:P94170; CAH_ANASP CARBONIC ANHYDRASE PRECURSOR; E=4e-16 COG: VCA0274; COG3338 Carbonic anhydrase; E=6e-19 PFAM: PF00194; Eukaryotic-type carbonic anhy; E=4.1e-15. (210 aa) |
| | mqnA | Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (281 aa) |
| | moaA | Molybdopterin cofactor synthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (359 aa) |
| | trpG | Anthranilate synthase component II; PMID: 2656657 PMID: 6283099 PMID: 2404959 best DB hits: BLAST: pir:B82835; anthranilate synthase component II XF0211 [imported] -; E=4e-40 swissprot:P06193; PABA_SALTY PARA-AMINOBENZOATE SYNTHASE GLUTAMINE; E=4e-39 pir:NNPS2P; anthranilate synthase (EC 4.1.3.27) component II; E=6e-39 COG: XF0211; COG0512 Anthranilate/para-aminobenzoate synthases component; E=3e-41 TM0141_1; COG0512 Anthranilate/para-aminobenzoate synthases; E=7e-37 DR1766; COG0512 Anthranilate/para-aminobenzoate synthases component; E=3e-36 PFAM: PF00117; Glutamine amidotransferase c [...] (244 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (331 aa) |
| | RB3733 | dTDP-glucose 4-6-dehydratase; PMID: 9174344 best DB hits: BLAST: pir:G82785; dTDP-glucose 4-6-dehydratase XF0611 [imported] - Xylella; E=1e-116 pir:S75550; dTDP-glucose 4-6-dehydratase - Synechocystis sp. (strain; E=1e-114 pir:T00419; dTDP-glucose 4-6-dehydratase homolog T30B22.4 -; E=1e-101 COG: XF0611; COG0451 Nucleoside-diphosphate-sugar epimerases; E=1e-117 MTH1789; COG1088 dTDP-D-glucose 4,6-dehydratase; E=2e-21 PA3554_2; COG0451 Nucleoside-diphosphate-sugar epimerases; E=3e-21 PFAM: PF01073; 3-beta hydroxysteroid dehydrogenase; E=0.0012 PF00106; short chain dehydrogenase; E=0.006 [...] (336 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (668 aa) |
| | RB3601 | Probable alginate lyase [Precursor]; PMID: 8200539 best DB hits: BLAST: embl:CAB61821.1; (AL133236) putative polyguluronate lyase; E=1e-33 ddbj:BAA83339.1; (AB030481) polyguluronate lyase [Corynebacterium; E=7e-33 swissprot:Q59478; ALYA_KLEPN ALGINATE LYASE PRECURSOR; E=4e-08 PFAM: PF00217; ATP:guanido phosphotransferase; E=0.69. (243 aa) |
| | RB3597 | NifS protein homolog yurW; PMID: 9384377 PMID: 2644218 PMID: 3040672 PMID: 8464885 PMID: 8161529 best DB hits: BLAST: pir:T35993; probable aminotransferase - Streptomyces coelicolor; E=3e-98 pir:S76601; hypothetical protein - Synechocystis sp. (strain PCC; E=1e-97 pir:F70019; nifS protein homolog yurW - Bacillus subtilis -----; E=3e-95 COG: slr0077; COG0520 Selenocysteine lyase; E=1e-98 PFAM: PF00266; Aminotransferase class-V; E=7.2e-16. (431 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (166 aa) |
| | RB344 | Probable xanthan lyase; PMID: 11157235 PMID: 10966413 best DB hits: BLAST: ddbj:BAB21059.1; (AB037178) xanthan lyase [Bacillus sp. GL1]; E=3e-13 gb:AAG24953.1; AF242413_1 (AF242413) XalA [Paenibacillus; E=2e-10 gb:AAG42262.1; AF318176_1 (AF318176) putative xanthan lyase XalB; E=0.050 PFAM: PF00070; Pyridine nucleotide-disulphide; E=0.00077. (700 aa) |
| | RB3417 | Pectate lyase; PMID: 10198006 best DB hits: BLAST: gb:AAD25394.1; (AF121904) pectate lyase [Azospirillum irakense]; E=7e-51 ddbj:BAA81752.1; (AB028877) pectate lyase E [Bacillus sp; E=3e-49 gb:AAG29353.1; AF279264_1 (AF279264) pectate lyase [Pseudomonas; E=2e-48. (353 aa) |
| | nanA | Probable N-acetylneuraminate lyase; PMID: 8081752 PMID: 3909108 PMID: 10952301 best DB hits: BLAST: pir:E82157; probable N-acetylneuraminate lyase VC1776 [imported] -; E=2e-39 embl:CAC27797.1; (AJ271330) acylneuraminate lyase [Sus scrofa]; E=7e-36 gb:AAG18989.1; (AE004999) dihydrodipicolinate synthase; DapA; E=2e-18 COG: VC1776; COG0329 Dihydrodipicolinate synthetase/N-acetylneuraminate; E=2e-40 PFAM: PF00701; Dihydrodipicolinate synthetase famil; E=2.7e-23. (322 aa) |
| | rluD-2 | Ribosomal large subunit pseudouridine synthase D; Best DB hits: BLAST: swissprot:Q45480; YLYB_BACSU HYPOTHETICAL 33.7 KD PROTEIN IN; E=4e-31 swissprot:P50513; RLUD_ZYMMO RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE; E=2e-30 ddbj:BAB06261.1; (AP001515) BH2542~unknown conserved protein; E=3e-30 COG: BH2542; COG0564 Pseudouridylate synthases, 23S RNA-specific; E=3e-31 PFAM: PF01479; S4 domain; E=5.2e-10 PF00849; RNA pseudouridylate synthase; E=6.4e-30; Belongs to the pseudouridine synthase RluA family. (321 aa) |
| | speD | Probable S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine. (164 aa) |
| | RB3174 | Ribosomal large subunit pseudouridine synthase B; PMID: 7934829 best DB hits: BLAST: swissprot:O67444; YE64_AQUAE HYPOTHETICAL PROTEIN AQ_1464 -----; E=4e-47 pir:T36871; probable pseudouridine synthase - Streptomyces; E=1e-40 swissprot:O33210; YH11_MYCTU HYPOTHETICAL 27.6 KDA PROTEIN RV1711; E=9e-38 COG: aq_1464; COG1187 16S rRNA uridine-516 pseudouridylate synthase and; E=3e-48 PFAM: PF01479; S4 domain; E=3.1e-11 PF00849; RNA pseudouridylate synthase; E=6.5e-13. (395 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (222 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (314 aa) |
| | queE | Conserved hypothetical protein-putative radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (257 aa) |
| | RB2568 | Best DB hits: BLAST: pir:C75206; L-fuculose-phosphate aldolase (EC 4.1.2.17) - Pyrococcus; E=3e-18 pir:E71241; L-fuculose-phosphate aldolase (EC 4.1.2.17) - Pyrococcus; E=5e-18 gb:AAK03448.1; (AE006174) unknown [Pasteurella multocida]; E=2e-16 COG: PAB0117; COG0235 Ribulose-5-phosphate 4-epimerase and related; E=2e-19 PFAM: PF00596; Class II Aldolase and Adducin N-t; E=2.4e-21. (287 aa) |
| | gmd-2 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (350 aa) |
| | gmd | GDP-D-mannose dehydratase 1; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (325 aa) |
| | rfbB | dTDP-glucose-4,6-dehydratase; PMID: 8022265 best DB hits: BLAST: gb:AAG35060.1; AF314183_2 (AF314183) dTDP-glucose-4,6-dehydratase; E=1e-110 gb:AAF33465.1; (AF233324) 89% identity with E. coli; E=1e-107 swissprot:P55294; RFBB_NEIMB DTDP-GLUCOSE 4,6-DEHYDRATASE -----; E=1e-106 COG: NMB0063; COG1088 dTDP-D-glucose 4,6-dehydratase; E=1e-107 PFAM: PF01073; 3-beta hydroxysteroid dehydro; E=0.53 PF00106; short chain dehydrogenase; E=0.073 PF01370; NAD dependent epimerase/dehyd; E=6e-141; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (392 aa) |
| | rluA | PMID: 1630901,7493321 best DB hits: BLAST: swissprot:P39219; RLUA_ECOLI RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE; E=5e-15 gb:AAG54362.1; AE005182_11 (AE005182) orf, hypothetical protein; E=3e-14 pir:C82498; ribosomal large chain pseudouridine synthase A VCA0104; E=5e-14 COG: rluA; COG0564 Pseudouridylate synthases, 23S RNA-specific; E=5e-16 PFAM: PF00849; RNA pseudouridylate synthase; E=4.8e-31. (232 aa) |
| | citB | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (428 aa) |
| | RB1856 | Delta-aminolevulinic acid dehydratase; PMID: 8226669 best DB hits: BLAST: ddbj:BAA35069.1; (AB015492) porphobilinogen synthase; E=1e-114 swissprot:P45622; HEM2_BRAJA DELTA-AMINOLEVULINIC ACID DEHYDRATASE; E=1e-108 swissprot:Q59643; HEM2_PSEAE DELTA-AMINOLEVULINIC ACID DEHYDRATASE; E=1e-105 COG: PA5243; COG0113 Delta-aminolevulinic acid dehydratase; E=1e-106 PFAM: PF00490; Delta-aminolevulinic acid dehydratas; E=1.8e-183; Belongs to the ALAD family. (404 aa) |
| | lysA | Hypothetical 49.9 kDa protein Y4YA-putative diaminopimelate decarboxylase; PMID: 9163424 best DB hits: BLAST: gb:AAG45731.1; AF229441_2 (AF229441) y4yA [Sinorhizobium fredii]; E=7e-30 swissprot:P55709; Y4YA_RHISN HYPOTHETICAL 49.9 KD PROTEIN Y4YA; E=3e-29 gb:AAG45729.1; AF229440_2 (AF229440) y4yA [Sinorhizobium fredii]; E=3e-26 COG: sll0504; COG0019 Diaminopimelate decarboxylase; E=7e-08 PFAM: PF02784; Pyridoxal-dependent decarboxyla; E=0.71. (489 aa) |
| | ilvD-3 | Dihydroxy-acid dehydratase; PMID: 8688087 best DB hits: BLAST: pir:T36902; probable dihydroxy-acid dehydratase - Streptomyces; E=1e-172 embl:CAB61588.1; (AL133210) putative dihydroxy-acid dehydratase; E=1e-132 swissprot:Q58672; ILVD_METJA DIHYDROXY-ACID DEHYDRATASE (DAD); E=4e-79 COG: MJ1276; COG0129 Dihydroxyacid dehydratase/phosphogluconate; E=4e-80 ilvD; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; E=1e-51 XF0099; COG0129 Dihydroxyacid dehydratase/phosphogluconate; E=1e-50 PFAM: PF00920; Dehydratase family; E=1.2e-108; Belongs to the IlvD/Edd family. (577 aa) |
| | RB1411 | Probable dihydrodipicolinate synthase; PMID: 10761919 best DB hits: BLAST: pir:H81878; probable dihydrodipicolinate synthase (EC 4.2.1.52); E=2e-08 pir:D81141; dihydrodipicolinate synthase NMB0929 [imported] -; E=3e-08 pir:D83488; probable dihydrodipicolinate synthetase PA1254; E=7e-07 COG: NMB0929; COG0329 Dihydrodipicolinate synthetase/N-acetylneuraminate; E=3e-09 PFAM: PF00701; Dihydrodipicolinate synthetase f; E=9.1e-05; Belongs to the DapA family. (342 aa) |
| | leuA-3 | 2-isopropylmalate synthase; PMID: 6171647 best DB hits: BLAST: swissprot:O66682; LY41_AQUAE PUTATIVE LYASE AQ_356 ----- pir:; E=1e-132 pir:E75045; 2-isopropylmalate synthase (leua-3) PAB0894 - Pyrococcus; E=1e-130 swissprot:Q9WZ22; LY41_THEMA PUTATIVE LYASE TM0552 ----- pir:; E=1e-124 COG: aq_356; COG0119 Isopropylmalate/homocitrate/citramalate synthases; E=1e-133 PFAM: PF00682; HMGL-like; E=6.6e-09; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa) |
| | RB12905 | Acetolactate synthase III [Precursor]; PMID: 1896019 best DB hits: BLAST: swissprot:P27819; ILV3_BRANA ACETOLACTATE SYNTHASE III,; E=1e-167 swissprot:P27818; ILV1_BRANA ACETOLACTATE SYNTHASE I, CHLOROPLAST; E=1e-167 pir:S15004; acetolactate synthase (EC 4.1.3.18) 2 precursor - rape; E=1e-167 COG: AF1720; COG0028 Thiamine pyrophosphate-requiring enzymes; E=1e-129 ilvG; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate; E=1e-123 slr2088; COG0028 Thiamine pyrophosphate-requiring enzymes; E=1e-121 PFAM: PF02776; Thiamine pyrophosphate enzyme,; E=9.8e-87 PF00205; Thiamine pyrop [...] (619 aa) |
| | rluD | Ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (334 aa) |
| | mutM | Probable formamidopyrimidine-DNA glycosylase; PMID: 7704272 best DB hits: BLAST: swissprot:O53191; YO64_MYCTU PUTATIVE DNA GLYCOSYLASE RV2464C; E=6e-55 embl:CAC10002.1; (AL442143) putative DNA repair hydrolase; E=6e-46 swissprot:P95744; FPG_SYNEN FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; E=1e-14 COG: Rv2464c; COG0266 Formamidopyrimidine-DNA glycosylase; E=2e-55 PFAM: PF01149; Formamidopyrimidine-DNA glycos; E=4.3e-40. (294 aa) |
| | pyrF | Orotidine 5-phosphate decarboxylase; PMID: 8787418 best DB hits: BLAST: swissprot:P96076; DCOP_THETH OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; E=3e-38 pir:G75302; orotidine 5'-phosphate decarboxylase - Deinococcus; E=5e-35 gb:AAG19923.1; (AE005076) orotidine-5'-monophosphate (Ura3); PyrF; E=4e-33 COG: DR2200_2; COG0284 Orotidine-5'-phosphate decarboxylase; E=1e-35; Belongs to the OMP decarboxylase family. Type 2 subfamily. (302 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa) |
| | leuA | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (511 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa) |
| | eno | Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; PMID: 8325851 PMID: 7771772 best DB hits: BLAST: ddbj:BAB03011.1; (AP001297) dihydroxy-acid dehydratase; E=0.0 swissprot:Q10318; ILV3_SCHPO PUTATIVE DIHYDROXY-ACID DEHYDRATASE,; E=0.0 embl:CAA89540.1; (Z49516) ORF YJR016c [Saccharomyces cerevisiae]; E=1e-170 COG: YJR016c; COG0129 Dihydroxyacid dehydratase/phosphogluconate; E=1e-171 ilvD; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; E=7e-81 PA0353; COG0129 Dihydroxyacid dehydratase/phosphogluconate; E=4e-80 PFAM: PF00391; PEP-utilizing enzyme, mobile do; E=0.48 PF00920; Dehydratase family; [...] (587 aa) |
| | mqnD | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (302 aa) |
| | RB11948 | Probable secreted protein-putative xanthan lyase related; PMID: 97000351 best DB hits: BLAST: ddbj:BAB21059.1; (AB037178) xanthan lyase [Bacillus sp. GL1]; E=2e-08 embl:CAB62685.1; (AL133422) putative membrane protein; E=3e-08 embl:CAB62757.1; (AL133424) putative secreted protein; E=8e-08 PFAM: PF00070; Pyridine nucleotide-disulphide; E=0.00038. (714 aa) |
| | ilvD | Dihydroxy-acid dehydratase; PMID: 8325851 PMID: 7771772 best DB hits: BLAST: swissprot:P77596; YAGF_ECOLI HYPOTHETICAL 69.4 KD PROTEIN IN; E=0.0 swissprot:P39358; YJHG_ECOLI HYPOTHETICAL 70.0 KD PROTEIN IN; E=0.0 pir:S56522; hypothetical protein f655 - Escherichia coli -----; E=0.0 COG: yagF; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; E=0.0 MJ1276; COG0129 Dihydroxyacid dehydratase/phosphogluconate; E=5e-48 ilvD; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; E=2e-34 PFAM: PF00920; Dehydratase family; E=3.6e-208; Belongs to the IlvD/Edd family. (671 aa) |
| | sul1 | Probable sulfate transporter; PMID: 10984043 best DB hits: BLAST: pir:B70979; hypothetical protein Rv3273 - Mycobacterium tuberculosis; E=2e-36 pir:D83631; probable sulfate transporter PA0103 [imported] -; E=3e-31 ddbj:BAB20551.1; (AB040415) Mig5 [Salmonella enterica serovar; E=9e-24 COG: PA0103; COG0659 Sulfate permease and related transporters (MFS; E=2e-32 DR2238; COG0288 Carbonic anhydrase; E=2e-24 slr0096; COG0659 Sulfate permease and related transporters (MFS; E=4e-15 PFAM: PF00916; Sulfate transporter family; E=1.5e-39 PF00484; Carbonic anhydrase; E=5.9e-12 PF02878; Phosphogluco [...] (768 aa) |
| | faoA | Fatty oxidation complex alpha subunit; PMID: 1607366 best DB hits: BLAST: swissprot:P28793; FAOB_PSEFR FATTY OXIDATION COMPLEX ALPHA SUBUNIT; E=6e-27 pir:G83269; fatty-acid oxidation complex alpha-subunit PA3014; E=2e-25 pir:T34706; fatty acid oxidation complex alpha-subunit -; E=1e-24 COG: PA3014_2; COG1250 3-Hydroxyacyl-CoA dehydrogenase; E=2e-26 PFAM: PF02737; 3-hydroxyacyl-CoA dehydrogenase, NAD; E=6.3e-15 PF00725; 3-hydroxyacyl-CoA dehydrogenase, C-t; E=7.2e-14. (396 aa) |
| | thrC | Threonine synthase precursor; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (456 aa) |
| | argH | Argininosuccinate lyase; PMID: 2121708 PMID: 10984043 best DB hits: BLAST: pir:B81175; argininosuccinate lyase NMB0637 [imported] - Neisseria; E=1e-110 pir:C81930; probable argininosuccinate lyase (EC 4.3.2.1) NMA0847; E=1e-110 swissprot:P50987; ARLY_PSEAE ARGININOSUCCINATE LYASE; E=1e-107 COG: NMB0637; COG0165 Argininosuccinate lyase; E=1e-111 PAB0829; COG0015 Adenylosuccinate lyase; E=5e-14 PFAM: PF00206; Lyase; E=3.2e-82. (660 aa) |
| | trpB | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa) |
| | RB10616 | Altronate hydrolase; PMID: 9278503 PMID: 3038546 best DB hits: BLAST: ddbj:BAB04209.1; (AP001508) altronate hydrolase [Bacillus; E=6e-65 gb:AAG58224.1; AE005539_1 (AE005539) altronate hydrolase; E=2e-64 swissprot:P42604; UXAA_ECOLI ALTRONATE HYDROLASE (ALTRONIC ACID; E=2e-63 COG: BH0490; COG2721 Altronate dehydratase; E=6e-66. (634 aa) |
| | fabZ | Probable beta-hydroxyacyl-ACP dehydratase; PMID: 7806516 best DB hits: BLAST: gb:AAF98278.1; AF197933_8 (AF197933) beta-hydroxyacyl-ACP; E=1e-05 pir:H81661; (3R)-hydroxymyristol-(acyl carrier protein) dehydratase; E=4e-05 pir:B33171; hypothetical 17K protein (lpxA 5' region) - Escherichia; E=5e-05 COG: fabZ; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier; E=5e-06 PFAM: PF01377; Thioester dehydrase; E=1.3e-15. (178 aa) |
| | gly1 | Low specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (349 aa) |
| | fae | Probable D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hps-2); Best DB hits: BLAST: gb:AAB89943.1; (AE001014) D-arabino 3-hexulose 6-phosphate; E=4e-41 pir:D69063; conserved hypothetical protein MTH1474 -; E=2e-40 gb:AAG32954.1; (AF032114) formaldehyde-activating enzyme; E=1e-37 COG: AF1305_1; COG1795 Uncharacterized archaeal domain; E=4e-42. (196 aa) |
| | cysM | Cysteine synthase B; PMID: 2188958 best DB hits: BLAST: swissprot:P16703; CYSM_ECOLI CYSTEINE SYNTHASE B (O-ACETYLSERINE; E=1e-30 pir:D82758; cysteine synthase XF0831 [imported] - Xylella fastidiosa; E=1e-30 swissprot:P95230; CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE; E=2e-30 COG: cysM; COG0031 Cysteine synthase; E=1e-31 PFAM: PF00291; Pyridoxal-phosphate dependent enzyme; E=5.9e-51. (323 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; PMID: 1896020 PMID: 7007653 PMID: 6355484 best DB hits: BLAST: swissprot:P26938; TRPC_AZOBR INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=6e-55 swissprot:P94327; TRPC_BRAJA INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=3e-52 swissprot:Q9ZFA7; TRPC_RHOSH INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=2e-51 COG: XF0213; COG0134 Indole-3-glycerol phosphate synthase; E=5e-51 PFAM: PF00218; Indole-3-glycerol phosphate synthase; E=2.6e-111; Belongs to the TrpC family. (259 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (262 aa) |
| | RB10092 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase; Best DB hits: BLAST: ref:XP_002773.1; CGI-105 protein [Homo sapiens]; E=4e-56 gb:AAD34100.1; AF151863_1 (AF151863) CGI-105 protein [Homo; E=6e-56 gb:AAF55945.1; (AE003737) CG6028 gene product [Drosophila; E=3e-54 COG: BH2000; COG0179 2-keto-4-pentenoate; E=1e-45 PFAM: PF01557; Fumarylacetoacetate (FAA) hydro; E=5.1e-83. (342 aa) |
| | ilvN | Probable acetolactate synthase small subunit; PMID: 6308579 PMID: 1851954 best DB hits: BLAST: swissprot:O27492; ILVH_METTH PROBABLE ACETOLACTATE SYNTHASE SMALL; E=1e-27 pir:S74358; acetolactate synthase ilvN - Synechocystis sp. (strain; E=5e-27 gb:AAB89532.1; (AE000985) acetolactate synthase, small subunit; E=9e-27 COG: MTH1443; COG0440 Acetolactate synthase, small subunit; E=9e-29 PFAM: PF01842; ACT domain; E=1.1e-18. (194 aa) |
| | hisH | Amidotransferase hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa) |
| | cpcE | Similar to phycocyanin alpha phycocyanobilin lyase CpcE; PMID: 9882677 best DB hits: BLAST: pir:S74670; hypothetical protein sll1663 - Synechocystis sp. (strain; E=0.069 pir:D69108; phycocyanin alpha phycocyanobilin lyase CpcE -; E=0.20 pir:F83358; hypothetical protein PA2293 [imported] - Pseudomonas; E=0.35 COG: sll1663; COG1413 Phycocyanin alpha-subunit phycocyanobilin lyase and; E=0.007. (238 aa) |
| | phr-3 | Probable deoxyribodipyrimidine photolyase; PMID: 7813451 PMID: 2668276 best DB hits: BLAST: pir:A83065; hypothetical protein PA4657 [imported] - Pseudomonas; E=4e-47 swissprot:P12769; PHR_METTH DEOXYRIBODIPYRIMIDINE PHOTOLYASE (DNA; E=6e-41 swissprot:P34205; PHR_CARAU DEOXYRIBODIPYRIMIDINE PHOTOLYASE (DNA; E=4e-37 COG: PA4657; COG3380 Predicted NAD/FAD-dependent oxidoreductase; E=3e-48 MTH904; COG0415 Deoxyribodipyrimidine photolyase; E=5e-42 sll1135; COG3380 Predicted NAD/FAD-dependent oxidoreductase; E=1e-21 PFAM: PF00875; DNA photolyase; E=6.3e-06 PF02254; KTN NAD-binding domain; E= [...] (837 aa) |
| | nifS-4 | NifS-like aminotranfserase-putative cysteine desulfurase; PMID: 8663056 PMID: 10600118 PMID: iscS best DB hits: BLAST: pir:E81852; NifS-like aminotranfserase NMA1594 [imported] -; E=1e-63 gb:AAF62329.1; (AE002486) nifS protein [Neisseria meningitidis; E=9e-63 pir:A71652; iron-sulfur cofactor synthesis protein RP486 -; E=1e-60 COG: NMB1379; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; E=8e-64 PFAM: PF00266; Aminotransferase class-V; E=3.4e-70. (395 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; PMID: 6350601 best DB hits: BLAST: gb:AAK05382.1; AE006360_11 (AE006360) diaminopimelate; E=1e-106 swissprot:P31851; TABA_PSESZ TABA PROTEIN ----- pir: S27649; E=6e-92 swissprot:O27390; DCDA_METTH DIAMINOPIMELATE DECARBOXYLASE (DAP; E=7e-59 COG: MTH1335; COG0019 Diaminopimelate decarboxylase; E=7e-60 PFAM: PF02784; Pyridoxal-dependent decarboxy; E=3.1e-40 PF00278; Pyridoxal-dependent decarboxy; E=1.4e-29. (427 aa) |
| | RB8979 | Probable L-serine dehydratase, alpha chain; PMID: 2504697 PMID: 8436113 best DB hits: BLAST: swissprot:O34607; SDHA_BACSU PROBABLE L-SERINE DEHYDRATASE, ALPHA; E=1e-26 ddbj:BAB06215.1; (AP001515) L-serine dehydratase alpha subunit; E=9e-26 gb:AAK04929.1; AE006316_10 (AE006316) alpha-subuni L-serine; E=5e-25 COG: BS_ylpA; COG1760 L-serine deaminase; E=1e-27. (552 aa) |
| | bcpC | Best DB hits: BLAST: pir:D69154; probable phosphonopyruvate decarboxylase (EC 4.1.1.-) 1; E=3e-86 gb:AAB89821.1; (AE001005) phosphonopyruvate decarboxylase; E=2e-64 pir:D69079; phosphonopyruvate decarboxylase (EC 4.1.1.-) -; E=7e-48 COG: MTH418; COG1015 Phosphopentomutase/predicted phosphoglycerate mutase; E=3e-87 MTH1591; COG1015 Phosphopentomutase/predicted phosphoglycerate; E=7e-49 MJ1612; COG1015 Phosphopentomutase/predicted phosphoglycerate mutase; E=2e-47 PFAM: PF02023; SCAN domain; E=0.75 PF01676; Metalloenzyme superfamily; E=4.3e-29. (444 aa) |
| | hpaG | Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomaerase; PMID: 8550403 best DB hits: BLAST: embl:CAC24092.1; (AL512982) hypothetical [Sulfolobus; E=1e-48 embl:CAB55723.1; (AL117387) hypothetical protein SCF41.20c; E=3e-18 pir:T45421; probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomaerase; E=1e-10 COG: Rv2993c; COG0179 2-keto-4-pentenoate; E=2e-11 PFAM: PF01557; Fumarylacetoacetate (FAA) hydro; E=0.0074. (287 aa) |
| | RB8806 | Conserved hypothetical protein-putative 6-pyruvoyl-tetrahydropterin synthase; Best DB hits: BLAST: embl:CAC12079.1; (AL445066) conserved hypothetical protein; E=2e-11 swissprot:Q58668; YC72_METJA HYPOTHETICAL PROTEIN MJ1272 -----; E=1e-10 swissprot:O27296; YC28_METTH HYPOTHETICAL PROTEIN MTH1228 -----; E=2e-10 COG: Ta0950; COG0720 6-pyruvoyl-tetrahydropterin synthase; E=1e-12 PFAM: PF01242; 6-pyruvoyl tetrahydropterin synthas; E=0.0016 PF01945; Domain of unknown function; E=0.87. (175 aa) |
| | dapA-4 | Dihydrodipicolinate synthase DapA; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family. (319 aa) |
| | sdaA | L-serine dehydratase; PMID: 2504697 best DB hits: BLAST: pir:B83341; L-serine dehydratase PA2443 [imported] - Pseudomonas; E=1e-141 pir:D82974; L-serine dehydratase PA5379 [imported] - Pseudomonas; E=1e-127 swissprot:O86564; SDHL_STRCO L-SERINE DEHYDRATASE (L-SERINE; E=1e-126 COG: PA2443; COG1760 L-serine deaminase; E=1e-142. (500 aa) |
| | phr-2 | Deoxyribodipyrimidine photolyase; PMID: 7813451 PMID: 2668276 best DB hits: BLAST: swissprot:P12769; PHR_METTH DEOXYRIBODIPYRIMIDINE PHOTOLYASE (DNA; E=3e-58 gb:AAF81696.1; AF246697_1 (AF246697) CPD-photolyase [Fowlpox; E=1e-54 swissprot:P34205; PHR_CARAU DEOXYRIBODIPYRIMIDINE PHOTOLYASE (DNA; E=6e-54 COG: MTH904; COG0415 Deoxyribodipyrimidine photolyase; E=3e-59 PFAM: PF00875; DNA photolyase; E=0.0034. (507 aa) |
| | psd-2 | Phosphatidylserine decarboxylase precursor; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (318 aa) |
| | odc | Lysine/ornithine decarboxylase; PMID: 20528325 best DB hits: BLAST: ddbj:BAA24923.1; (AB011029) lysineornithine decarboxylase; E=5e-59 ddbj:BAA83427.1; (AB031066) ornithine decarboxylase [Nicotiana; E=1e-46 pir:T03035; ornithine decarboxylase (EC 4.1.1.17) - common tobacco; E=1e-46 COG: aq_728; COG0019 Diaminopimelate decarboxylase; E=8e-44 PFAM: PF02784; Pyridoxal-dependent decarboxy; E=4e-55 PF00278; Pyridoxal-dependent decarboxy; E=1.8e-17; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (398 aa) |
| | purB | Adenylosuccinate lyase; PMID: 96015068 PMID: 2111814 best DB hits: BLAST: gb:AAB60684.1; (U20225) adenylosuccinate lyase [Mus musculus]; E=1e-144 gb:AAC83935.1; (AF106656) adenylosuccinate lyase [Homo sapiens]; E=1e-140 gb:AAH00253.1; AAH00253 (BC000253) adenylosuccinate lyase [Homo; E=1e-140 COG: YLR359w; COG0015 Adenylosuccinate lyase; E=1e-132 PFAM: PF00206; Lyase; E=2.5e-57; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (485 aa) |
| | purE-2 | Conserved hypothetical protein-putative phosphoribosylcarboxyaminoimidazole mutase (purE); PMID: 98049343 PMID: 8809759 best DB hits: BLAST: gb:AAB89969.1; (AE001016) conserved hypothetical protein; E=4e-29 pir:S76797; hypothetical protein - Synechocystis sp. (strain PCC; E=7e-28 gb:AAD29318.1; AF117208_1 (AF117208) circadian phase modifier; E=2e-24 COG: AF1275; COG1691 NCAIR mutase (PurE)-related proteins; E=4e-30. (282 aa) |
| | nnrD | Conserved hypothetical protein-putative sugar kinase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (304 aa) |
| | hemH | Probable ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (351 aa) |
| | ilvH | Conserved hypothetical protein-putative acetolactate synthase small regulatory subunit; PMID: 98037514 best DB hits: BLAST: pir:A69115; hypothetical protein MTH1854 - Methanobacterium; E=4e-13 pir:D69083; hypothetical protein MTH162 - Methanobacterium; E=4e-09 gb:AAB89585.1; (AE000988) acetolactate synthase, small subunit,; E=5e-07 PFAM: PF01842; ACT domain; E=0.0014. (170 aa) |
| | RB8221 | O-acetylhomoserine sulfhydrylase; PMID: 7704274 best DB hits: BLAST: ddbj:BAB06322.1; (AP001516) O-acetylhomoserine sulfhydrylase; E=1e-123 pir:D72324; O-acetylhomoserine sulfhydrylase - Thermotoga maritima; E=1e-114 pir:T40463; O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) -; E=1e-110 COG: BH2603; COG2873 O-acetylhomoserine sulfhydrylase; E=1e-124 DR0921; COG0626 Cystathionine beta-lyases/cystathionine; E=7e-63 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=6.3e-204. (439 aa) |
| | fabZ-4 | Probable beta-hydroxyacyl-ACP dehydratase; PMID: 7806516 best DB hits: BLAST: gb:AAF98278.1; AF197933_8 (AF197933) beta-hydroxyacyl-ACP; E=2e-14 gb:AAK04875.1; AE006311_6 (AE006311); E=3e-14 pir:C82731; (3r)-hydroxymyristoyl ACP dehydrase XF1044 [imported] -; E=6e-14 COG: XF1044; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier; E=6e-15 PFAM: PF01377; Thioester dehydrase; E=2.1e-18 PF01575; MaoC like domain; E=0.0056. (177 aa) |
| | RB8082 | Conserved hypothetical protein-putative a deoxyribodipyrimidine photolyase-related protein; Best DB hits: BLAST: pir:S75597; hypothetical protein slr1343 - Synechocystis sp. (strain; E=6e-94 gb:AAG19190.1; (AE005016) Vng0705c [Halobacterium sp. NRC-1]; E=2e-91 pir:G82413; conserved hypothetical protein VCA0809 [imported] -; E=2e-83 COG: slr1343; COG3046 Deoxyribodipyrimidine photolyase-related proteins; E=6e-95. (566 aa) |
| | RB7999 | Hypothetical protein; Best DB hits: PFAM: PF00573; Ribosomal protein L4/L1 family; E=0.0042; Belongs to the DapA family. (357 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (547 aa) |
| | uroD | Uroporphyrinogen III synthase, uroporhyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (673 aa) |
| | RB7762 | Probable xanthan lyase; PMID: 11157235 PMID: 10347025 PMID: 10966413 best DB hits: BLAST: ddbj:BAB21059.1; (AB037178) xanthan lyase [Bacillus sp. GL1]; E=5e-08 gb:AAG24953.1; AF242413_1 (AF242413) XalA [Paenibacillus; E=3e-07 gb:AAG42262.1; AF318176_1 (AF318176) putative xanthan lyase XalB; E=0.003. (992 aa) |
| | RB7668 | Similar to malate synthase, glyoxysoomal [fragment]; PMID: 8547819 best DB hits: BLAST: swissprot:P45458; MASY_SOYBN MALATE SYNTHASE, GLYOXYSOMAL (MS); E=0.60. (227 aa) |
| | hisBD | Best DB hits: BLAST: ddbj:BAB07300.1; (AP001519) imidazoleglycerol-phosphate; E=3e-49 swissprot:O33564; HIS7_RHOSH IMIDAZOLEGLYCEROL-PHOSPHATE; E=1e-48 swissprot:P34047; HIS7_ARATH IMIDAZOLEGLYCEROL-PHOSPHATE; E=2e-48 COG: BH3581; COG0131 Imidazoleglycerol-phosphate dehydratase; E=3e-50 PFAM: PF00475; Imidazoleglycerol-phosphate dehydrat; E=7e-96. (202 aa) |
| | fumC | Fumarate hydratase FumC; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (543 aa) |
| | mutM-2 | formamidopyrimidine-DNA glycosylase; PMID: 96102858 best DB hits: BLAST: swissprot:P55044; FPG_NEIMB FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; E=2e-29 swissprot:P95744; FPG_SYNEN FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; E=6e-29 prf:2204218A; formamidopyrimidine-DNA glycosylase [Neisseria; E=7e-28 COG: NMB1295; COG0266 Formamidopyrimidine-DNA glycosylase; E=2e-30 PFAM: PF01149; Formamidopyrimidine-DNA glycos; E=6.4e-14; Belongs to the FPG family. (300 aa) |
| | murQ | Glucokinase regulatory protein-related protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (302 aa) |
| | rfbE | CDP-tyvelose epimerase; PMID: 96125720 PMID: 97158136 PMID: 2793833 best DB hits: BLAST: gb:AAB48319.1; (U29691) CDP-tyvelose epimerase [Yersinia; E=2e-29 swissprot:P14169; RFBE_SALTI CDP-TYVELOSE-2-EPIMERASE -----; E=3e-27 pir:B33604; rfbE protein - Salmonella sp; E=7e-26 COG: HI0873; COG1088 dTDP-D-glucose 4,6-dehydratase; E=5e-19 BH3649; COG0451 Nucleoside-diphosphate-sugar epimerases; E=1e-14 PH0414; COG1088 dTDP-D-glucose 4,6-dehydratase; E=1e-14 PFAM: PF01370; NAD dependent epimerase/dehydratase; E=0.0012. (351 aa) |
| | nifS-3 | Cysteine desulfurase NifS; PMID: 10930739 PMID: 2553733 best DB hits: BLAST: gb:AAG01802.1; AF276772_1 (AF276772) cysteine desulfurase NifS; E=4e-53 swissprot:P12623; NIFS_ANASP NIFS PROTEIN ----- pir: C34443; E=2e-50 swissprot:Q43884; NIFS_ANAAZ NIFS PROTEIN ----- gb: AAA87249.1; E=3e-50 COG: yfhO; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; E=3e-51 PFAM: PF00266; Aminotransferase class-V; E=7.9e-47. (381 aa) |
| | nifS-2 | Aminotransferase NifS-putative NifS homolog; PMID: 99411980 best DB hits: BLAST: pir:G69051; nifS protein - Methanobacterium thermoautotrophicum; E=8e-37 ddbj:BAB07775.1; (AP001520) aminotransferase required for NAD; E=1e-34 pir:F70019; nifS protein homolog yurW - Bacillus subtilis -----; E=4e-27 COG: MTH1389; COG0520 Selenocysteine lyase; E=8e-38 aq_739; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; E=1e-20 BH3469; COG0520 Selenocysteine lyase; E=5e-20 PFAM: PF00266; Aminotransferase class-V; E=1.4e-19. (419 aa) |
| | thiC | Thiamine biosynthesis protein THIC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (441 aa) |
| | MoaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (203 aa) |
| | fabZ-3 | Probable hydroxymyristoyl-(acyl carrier protein) dehydratase; PMID: 7806516 best DB hits: BLAST: ddbj:BAB07454.1; (AP001519) hydroxymyristoyl-(acyl carrier; E=4e-09 pir:A70305; (3R)-hydroxymyristoyl-(acyl carrier protein) dehydratase; E=5e-09 pir:H71826; (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; E=7e-09 COG: BH3735; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier; E=4e-10 PFAM: PF01377; Thioester dehydrase; E=0.00031. (193 aa) |
| | fabZ-2 | Probable hydroxymyristoyl-(acyl carrier protein) dehydratase; PMID: 7806516 best DB hits: BLAST: gb:AAK04875.1; AE006311_6 (AE006311); E=3e-11 pir:D70065; (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; E=5e-11 gb:AAF98278.1; AF197933_8 (AF197933) beta-hydroxyacyl-ACP; E=9e-11 COG: BS_ywpB; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier; E=5e-12 PFAM: PF01377; Thioester dehydrase; E=6e-11. (194 aa) |
| | aroA | AroA(G) protein (phospho-2-dehydro-3-deoxyheptonate aldolase / chorismate mutase); PMID: 10425687 best DB hits: BLAST: pir:E72388; hypothetical protein TM0343 - Thermotoga maritima; E=3e-85 gb:AAG53674.1; AF318277_2 (AF318277); E=4e-79 ddbj:BAA85151.1; (AB018197) carboxysome formation protein; E=2e-72 COG: TM0343; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP); E=3e-86 BS_aroA_2; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate; E=2e-61 Ta0247; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP); E=6e-56 PFAM: PF00610; Domain found in Dishevelled, Egl; E=0.84 PF00 [...] (355 aa) |
| | hemD | PMID: 7665501 best DB hits: BLAST: gb:AAK00606.1; AF221100_3 (AF221100) uroporphyrinogen III; E=1e-89 swissprot:Q59294; HEM4_CLOJO PORPHYRIN BIOSYNTHESIS PROTEIN HEMD; E=1e-64 gb:AAC18588.1; (AF064061) uroporphyrinogen-III; E=3e-63 COG: NMB1156_2; COG0007 Uroporphyrinogen-III methylase; E=2e-44 sll0166_2; COG1587 Uroporphyrinogen-III synthase; E=7e-30 PFAM: PF00590; Tetrapyrrole (Corrin/Porphyrin); E=1.2e-63 PF02602; Uroporphyrinogen-III synthase H; E=7.1e-43. (510 aa) |
| | cyaA-2 | Adenylate cyclase 1; PMID: 9523018 best DB hits: BLAST: pir:C71320; probable adenylate cyclase - syphilis spirochete -----; E=8e-40 pir:F70563; probable transmembrane protein - Mycobacterium; E=2e-35 embl:CAA18817.1; (AL023093) putative membrane protein; E=4e-35 COG: TP0485; COG2114 Adenylate cyclase, family 3 (some proteins contain; E=8e-41 slr1991_2; COG2114 Adenylate cyclase, family 3 (some proteins; E=9e-14 PA3217; COG2114 Adenylate cyclase, family 3 (some proteins contain; E=4e-12 PFAM: PF00672; HAMP domain; E=8.7e-11 PF00211; Adenylate and Guanylate cyclase; E=7e-26. (589 aa) |
| | cysK | Cysteine synthase (O-acetylserine sulfhydrylase); PMID: 10930739 best DB hits: BLAST: gb:AAG01804.1; AF276772_3 (AF276772) O-acetylserine sulfhydrylase; E=3e-83 swissprot:P95230; CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE; E=1e-82 pir:H81161; probable cysteine synthase (EC 4.2.99.8) NMA0974; E=1e-81 COG: Rv2334; COG0031 Cysteine synthase; E=1e-83 PFAM: PF00291; Pyridoxal-phosphate dependent enzym; E=1.3e-119. (319 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (404 aa) |
| | fucA-2 | PMID: 2664711 best DB hits: BLAST: pir:E72546; L-fuculose-phosphate aldolase homolog - Aeropyrum pernix; E=6e-15 pir:C69054; L-fuculose-phosphate aldolase homolog - Methanobacterium; E=3e-14 swissprot:Q57199; YGBL_HAEIN HYPOTHETICAL PROTEIN HI1012 -----; E=9e-13 COG: APE1657; COG0235 Ribulose-5-phosphate 4-epimerase and related; E=6e-16 PFAM: PF00596; Class II Aldolase and Adducin N-t; E=8.8e-19. (430 aa) |
| | pabB | Para-aminobenzoate synthase component I; PMID: 3057324 best DB hits: BLAST: gb:AAG61067.1; AF322013_186 (AF322013) ID893 [Bradyrhizobium; E=7e-72 swissprot:P12679; PABB_KLEAE PARA-AMINOBENZOATE SYNTHASE COMPONENT; E=4e-59 gb:AAG56801.1; AE005404_4 (AE005404) p-aminobenzoate synthetase,; E=2e-57 COG: pabB; COG0147 Anthranilate/para-aminobenzoate synthases component I; E=4e-58 VC1303; COG0147 Anthranilate/para-aminobenzoate synthases component; E=4e-57 VNG0384G; COG0147 Anthranilate/para-aminobenzoate synthases; E=1e-45 PFAM: PF00425; chorismate binding enzyme; E=2.4e-103. (517 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (260 aa) |
| | fba | Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (343 aa) |
