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trpB trpB gly1 gly1 lysA-2 lysA-2 argD argD odc odc glgP glgP RB8221 RB8221 ilvE-2 ilvE-2 hisC hisC yqhK yqhK nifS-3 nifS-3 nifS-2 nifS-2 ectB ectB cysK cysK hemL hemL metB-2 metB-2 metB metB serC serC nifS-4 nifS-4 glyA glyA RB5984 RB5984 ilvA ilvA RB4631 RB4631 RB4382 RB4382 speA speA RB3597 RB3597 bioA bioA RB3176 RB3176 lysA lysA RB12934 RB12934 kamA kamA degT degT RB11582 RB11582 thrC thrC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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trpBTryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa)
gly1Low specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (349 aa)
lysA-2Diaminopimelate decarboxylase; PMID: 6350601 best DB hits: BLAST: gb:AAK05382.1; AE006360_11 (AE006360) diaminopimelate; E=1e-106 swissprot:P31851; TABA_PSESZ TABA PROTEIN ----- pir: S27649; E=6e-92 swissprot:O27390; DCDA_METTH DIAMINOPIMELATE DECARBOXYLASE (DAP; E=7e-59 COG: MTH1335; COG0019 Diaminopimelate decarboxylase; E=7e-60 PFAM: PF02784; Pyridoxal-dependent decarboxy; E=3.1e-40 PF00278; Pyridoxal-dependent decarboxy; E=1.4e-29. (427 aa)
argDProbable acetylornithine aminotransferase; PMID: 2199330 best DB hits: BLAST: swissprot:Q58131; ARGD_METJA ACETYLORNITHINE AMINOTRANSFERASE; E=2e-23 swissprot:P30268; YKAB_BACFI PROBABLE AMINOTRANSFERASE IN KATA; E=3e-19 embl:CAC11216.1; (AL445063) L-2,; E=5e-19 COG: MJ0721; COG0160 PLP-dependent aminotransferases; E=2e-24 PFAM: PF00202; Aminotransferase class-III; E=1.7e-39; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa)
odcLysine/ornithine decarboxylase; PMID: 20528325 best DB hits: BLAST: ddbj:BAA24923.1; (AB011029) lysineornithine decarboxylase; E=5e-59 ddbj:BAA83427.1; (AB031066) ornithine decarboxylase [Nicotiana; E=1e-46 pir:T03035; ornithine decarboxylase (EC 4.1.1.17) - common tobacco; E=1e-46 COG: aq_728; COG0019 Diaminopimelate decarboxylase; E=8e-44 PFAM: PF02784; Pyridoxal-dependent decarboxy; E=4e-55 PF00278; Pyridoxal-dependent decarboxy; E=1.8e-17; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (398 aa)
glgPPhosphorylase 2; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (830 aa)
RB8221O-acetylhomoserine sulfhydrylase; PMID: 7704274 best DB hits: BLAST: ddbj:BAB06322.1; (AP001516) O-acetylhomoserine sulfhydrylase; E=1e-123 pir:D72324; O-acetylhomoserine sulfhydrylase - Thermotoga maritima; E=1e-114 pir:T40463; O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) -; E=1e-110 COG: BH2603; COG2873 O-acetylhomoserine sulfhydrylase; E=1e-124 DR0921; COG0626 Cystathionine beta-lyases/cystathionine; E=7e-63 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=6.3e-204. (439 aa)
ilvE-2Putative branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (285 aa)
hisCHistidinol-phosphate aminotransferase; PMID: 1400209 best DB hits: BLAST: swissprot:P73807; HIS8_SYNY3 HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; E=1e-56 swissprot:P45358; HIS8_ACEXY HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; E=2e-52 gb:AAK00147.1; AF222753_2 (AF222753) putative aminotransferase; E=2e-43 COG: sll1958; COG0079 Histidinol-phosphate aminotransferase/Tyrosine; E=1e-57 PFAM: PF00155; Aminotransferase class-I; E=5.1e-06 PF00222; Aminotransferase class-II; E=1.3e-17; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase s [...] (362 aa)
yqhKProbable glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (500 aa)
nifS-3Cysteine desulfurase NifS; PMID: 10930739 PMID: 2553733 best DB hits: BLAST: gb:AAG01802.1; AF276772_1 (AF276772) cysteine desulfurase NifS; E=4e-53 swissprot:P12623; NIFS_ANASP NIFS PROTEIN ----- pir: C34443; E=2e-50 swissprot:Q43884; NIFS_ANAAZ NIFS PROTEIN ----- gb: AAA87249.1; E=3e-50 COG: yfhO; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; E=3e-51 PFAM: PF00266; Aminotransferase class-V; E=7.9e-47. (381 aa)
nifS-2Aminotransferase NifS-putative NifS homolog; PMID: 99411980 best DB hits: BLAST: pir:G69051; nifS protein - Methanobacterium thermoautotrophicum; E=8e-37 ddbj:BAB07775.1; (AP001520) aminotransferase required for NAD; E=1e-34 pir:F70019; nifS protein homolog yurW - Bacillus subtilis -----; E=4e-27 COG: MTH1389; COG0520 Selenocysteine lyase; E=8e-38 aq_739; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; E=1e-20 BH3469; COG0520 Selenocysteine lyase; E=5e-20 PFAM: PF00266; Aminotransferase class-V; E=1.4e-19. (419 aa)
ectBDiaminobutyric acid aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
cysKCysteine synthase (O-acetylserine sulfhydrylase); PMID: 10930739 best DB hits: BLAST: gb:AAG01804.1; AF276772_3 (AF276772) O-acetylserine sulfhydrylase; E=3e-83 swissprot:P95230; CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE; E=1e-82 pir:H81161; probable cysteine synthase (EC 4.2.99.8) NMA0974; E=1e-81 COG: Rv2334; COG0031 Cysteine synthase; E=1e-83 PFAM: PF00291; Pyridoxal-phosphate dependent enzym; E=1.3e-119. (319 aa)
hemLPMID: 7763385 PMID: 1672867 best DB hits: BLAST: pir:E81978; probable glutamate-1-semialdehyde 2,1-aminomutase (EC; E=1e-116 swissprot:Q40147; GSA_LYCES GLUTAMATE-1-SEMIALDEHYDE; E=1e-115 swissprot:Q06741; GSA_XANCH GLUTAMATE-1-SEMIALDEHYDE; E=1e-115 COG: BS_hemL; COG0001 Glutamate-1-semialdehyde aminotransferase; E=1e-116 PFAM: PF00202; Aminotransferase class-III; E=1.8e-125. (439 aa)
metB-2Cystathionine gamma-lyase homolog; PMID: 9843488 best DB hits: BLAST: pir:T45483; cystathionine gamma-lyase homolog [imported] -; E=9e-93 pir:F83595; probable cystathionine gamma-lyase PA0400 [imported] -; E=1e-92 gb:AAG19548.1; (AE005045) cystathionine alpha synthase; MetB; E=3e-92 COG: PA0400; COG0626 Cystathionine beta-lyases/cystathionine; E=1e-93 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=2.9e-199. (397 aa)
metBCystathionine gamma-synthase; PMID: 9002610 best DB hits: BLAST: embl:CAA64383.1; (X94756) cystathionine gamma-synthase; E=2e-75 gb:AAF26162.1; AC008261_19 (AC008261) putative cystathionine; E=2e-75 swissprot:P55217; METB_ARATH CYSTATHIONINE GAMMA-SYNTHASE,; E=3e-75 COG: APE1226; COG0626 Cystathionine beta-lyases/cystathionine; E=1e-64 PA5025; COG2873 O-acetylhomoserine sulfhydrylase; E=4e-47 PH1093; COG0626 Cystathionine beta-lyases/cystathionine; E=5e-47 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=4.5e-154. (434 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (383 aa)
nifS-4NifS-like aminotranfserase-putative cysteine desulfurase; PMID: 8663056 PMID: 10600118 PMID: iscS best DB hits: BLAST: pir:E81852; NifS-like aminotranfserase NMA1594 [imported] -; E=1e-63 gb:AAF62329.1; (AE002486) nifS protein [Neisseria meningitidis; E=9e-63 pir:A71652; iron-sulfur cofactor synthesis protein RP486 -; E=1e-60 COG: NMB1379; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; E=8e-64 PFAM: PF00266; Aminotransferase class-V; E=3.4e-70. (395 aa)
glyASerine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
RB5984Probable acetylornithine aminotransferase; PMID: 9002618 best DB hits: BLAST: swissprot:Q58131; ARGD_METJA ACETYLORNITHINE AMINOTRANSFERASE; E=2e-08 swissprot:O66442; ARGD_AQUAE ACETYLORNITHINE AMINOTRANSFERASE; E=5e-05 swissprot:O04866; ARGD_ALNGL ACETYLORNITHINE AMINOTRANSFERASE,; E=8e-04 COG: MJ0721; COG0160 PLP-dependent aminotransferases; E=2e-09; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (506 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa)
RB4631Probable aminotransferase; Best DB hits: BLAST: gb:AAC38670.2; (AF062345) putative perosamine synthetase; LpsC; E=9e-10 gb:AAB81626.1; (AF025396) probable perosamine synthetase [Vibrio; E=1e-08 gb:AAD28492.1; AF145039_4 (AF145039) aminotransferase spcS2; E=5e-08 COG: PAB0774; COG0399 Predicted pyridoxal phosphate-dependent enzyme; E=1e-08 PFAM: PF01041; DegT/DnrJ/EryC1/StrS family; E=0.099; Belongs to the DegT/DnrJ/EryC1 family. (444 aa)
RB4382Probable diaminopimelate decarboxylase; PMID: 6350601 PMID: 89056708 PMID: 94237165 best DB hits: BLAST: swissprot:P55709; Y4YA_RHISN HYPOTHETICAL 49.9 KD PROTEIN Y4YA; E=3e-40 gb:AAG45731.1; AF229441_2 (AF229441) y4yA [Sinorhizobium fredii]; E=3e-40 gb:AAG45729.1; AF229440_2 (AF229440) y4yA [Sinorhizobium fredii]; E=3e-33 COG: aq_728; COG0019 Diaminopimelate decarboxylase; E=7e-08 PA4839; COG1166 Arginine decarboxylase (spermidine biosynthesis); E=5e-05 XF1116_2; COG0019 Diaminopimelate decarboxylase; E=5e-05 PFAM: PF02784; Pyridoxal-dependent decarboxyla; E=5.9e-08. (555 aa)
speAArginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (668 aa)
RB3597NifS protein homolog yurW; PMID: 9384377 PMID: 2644218 PMID: 3040672 PMID: 8464885 PMID: 8161529 best DB hits: BLAST: pir:T35993; probable aminotransferase - Streptomyces coelicolor; E=3e-98 pir:S76601; hypothetical protein - Synechocystis sp. (strain PCC; E=1e-97 pir:F70019; nifS protein homolog yurW - Bacillus subtilis -----; E=3e-95 COG: slr0077; COG0520 Selenocysteine lyase; E=1e-98 PFAM: PF00266; Aminotransferase class-V; E=7.2e-16. (431 aa)
bioAPMID: 3058702 best DB hits: BLAST: gb:AAG53588.1; AF248314_3 (AF248314) DAPA aminotransferase BioA; E=2e-95 swissprot:P53656; BIOA_ERWHE; E=3e-92 gb:AAG60578.1; AF250776_2 (AF250776) DAPA-aminotransferase BioA; E=3e-91 COG: bioA; COG0161 Adenosylmethionine-8-amino-7-oxononanoate; E=3e-92 PFAM: PF00202; Aminotransferase class-III; E=3e-129; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
RB31768-amino-7-oxononanoate synthase; PMID: 8763940 PMID: 9387221 best DB hits: BLAST: swissprot:P22806; BIOF_BACSH 8-AMINO-7-OXONONANOATE SYNTHASE; E=1e-57 swissprot:P53556; BIOF_BACSU 8-AMINO-7-OXONONANOATE SYNTHASE; E=7e-57 ddbj:BAB07626.1; (AP001520) 8-amino-7-oxononanoate synthase; E=2e-51 COG: BS_bioF; COG0156 7-keto-8-aminopelargonate synthetase and related; E=6e-58 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=0.00067 PF00222; Aminotransferase class-II; E=1.6e-74. (395 aa)
lysAHypothetical 49.9 kDa protein Y4YA-putative diaminopimelate decarboxylase; PMID: 9163424 best DB hits: BLAST: gb:AAG45731.1; AF229441_2 (AF229441) y4yA [Sinorhizobium fredii]; E=7e-30 swissprot:P55709; Y4YA_RHISN HYPOTHETICAL 49.9 KD PROTEIN Y4YA; E=3e-29 gb:AAG45729.1; AF229440_2 (AF229440) y4yA [Sinorhizobium fredii]; E=3e-26 COG: sll0504; COG0019 Diaminopimelate decarboxylase; E=7e-08 PFAM: PF02784; Pyridoxal-dependent decarboxyla; E=0.71. (489 aa)
RB12934Conserved hypothetical protein-putative enzyme with TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (253 aa)
kamAL-lysine 2,3-aminomutase; Best DB hits: BLAST: pir:C82554; conserved hypothetical protein XF2474 [imported] -; E=7e-72 gb:AAG59345.1; AE005648_7 (AE005648) orf, hypothetical protein; E=4e-70 swissprot:P39280; YJEK_ECOLI HYPOTHETICAL 38.7 KD PROTEIN IN; E=1e-67 COG: XF2474; COG1509 Lysine 2,3-aminomutase; E=7e-73 PFAM: PF02587; Uncharacterized ACR, YjeK family COG; E=6e-109. (381 aa)
degTPleiotropic regulatory protein; PMID: 2104607 best DB hits: BLAST: swissprot:P15263; DEGT_BACST PLEIOTROPIC REGULATORY PROTEIN; E=2e-80 ddbj:BAA31964.1; (D64132) A porR mutant of Pophyromonas; E=3e-68 pir:D69025; pleiotropic regulatory protein DegT - Methanobacterium; E=2e-67 COG: MTH1188; COG0399 Predicted pyridoxal phosphate-dependent enzyme; E=2e-68 PFAM: PF01041; DegT/DnrJ/EryC1/StrS family; E=1.2e-146; Belongs to the DegT/DnrJ/EryC1 family. (417 aa)
RB11582Cysteine desulfurase; PMID: 10908675 PMID: 7496536 PMID: 8482384 best DB hits: BLAST: pir:A71960; probable nitrogenase cofactor synthesis protein nifS -; E=1e-50 pir:D64547; iron-sulfur cofactor synthesis protein - Helicobacter; E=2e-50 swissprot:Q43884; NIFS_ANAAZ NIFS PROTEIN ----- gb: AAA87249.1; E=6e-49 COG: jhp0206; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; E=1e-51 PFAM: PF00266; Aminotransferase class-V; E=1.6e-60. (398 aa)
thrCThreonine synthase precursor; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (456 aa)
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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