STRINGSTRING
aroE aroE pabB pabB aroB aroB aroK aroK serC serC serA serA pheA pheA hisC-2 hisC-2 AFE_0899 AFE_0899 tyrA tyrA aroA aroA aroC aroC aspC aspC trpA trpA trpB trpB trpF trpF AFE_2671 AFE_2671 trpC trpC trpD trpD pabA pabA trpE trpE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (298 aa)
pabBPara-aminobenzoate synthase, component I; Identified by similarity to SP:P05041; match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00553. (462 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (364 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (179 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
serAD-3-phosphoglycerate dehydrogenase; Identified by similarity to SP:P35136; match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
pheAChorismate mutase/prephenate dehydratase; Identified by similarity to SP:P27603; match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM PF01842; match to protein family HMM TIGR01807. (358 aa)
hisC-2Histidinol-phosphate aminotransferase; Identified by similarity to SP:P17731; match to protein family HMM PF00155; match to protein family HMM PF00266; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
AFE_0899Phospho-2-dehydro-3-deoxyheptonate aldolase; Identified by match to protein family HMM PF00793; match to protein family HMM TIGR01361. (338 aa)
tyrAPrephenate dehydrogenase; Identified by similarity to SP:P20692; match to protein family HMM PF02153. (301 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa)
aspCAspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. (393 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa)
trpFN-(5'phosphoribosyl)anthranilate isomerase; Identified by similarity to SP:Q56320; match to protein family HMM PF00697; Belongs to the TrpF family. (205 aa)
AFE_2671Phospho-2-dehydro-3-deoxyheptonate aldolase, putative; Identified by similarity to SP:P39912; match to protein family HMM PF00793. (372 aa)
trpCIndole-3-glycerol phosphate synthase; Identified by similarity to SP:P20577; match to protein family HMM PF00218; Belongs to the TrpC family. (263 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa)
pabAPara-aminobenzoate synthase glutamine amidotransferase component II; Identified by similarity to PIR:A01122; match to protein family HMM PF00117; match to protein family HMM TIGR00566. (190 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (505 aa)
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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