STRINGSTRING
AFE_2262 AFE_2262 rfbA rfbA AFE_3293 AFE_3293 moaB moaB glmU glmU cysN cysN cysD-2 cysD-2 AFE_3104 AFE_3104 polI polI AFE_3032 AFE_3032 rpoN rpoN cysNC cysNC cysD-1 cysD-1 AFE_2960 AFE_2960 nadD nadD glgC glgC coaD coaD AFE_2721 AFE_2721 dinB dinB AFE_2545 AFE_2545 rph rph dnaG dnaG holC holC mobA mobA dnaX dnaX holB holB dnaE2 dnaE2 AFE_1870 AFE_1870 AFE_1787 AFE_1787 pcnB pcnB AFE_1774 AFE_1774 AFE_1751 AFE_1751 AFE_1674 AFE_1674 dnaE dnaE cdsA cdsA AFE_1406 AFE_1406 AFE_1366 AFE_1366 AFE_1072 AFE_1072 AFE_1046 AFE_1046 glnD glnD rpoZ rpoZ AFE_0562 AFE_0562 ribF ribF glnE glnE cysC cysC selO selO AFE_0515 AFE_0515 kdsB kdsB holA holA galU galU dnaQ dnaQ pnp pnp ispD ispD rpoA rpoA rpoC rpoC rpoB rpoB AFE_0218 AFE_0218 gmhA-2 gmhA-2 dnaN dnaN
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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AFE_2262Sua5/YciO/YrdC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (186 aa)
rfbAGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (294 aa)
AFE_3293Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by similarity to SP:P29956; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. (479 aa)
moaBMolybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (180 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (455 aa)
cysNSulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (450 aa)
cysD-2Sulfate adenylyltransferase, small subunit; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. (312 aa)
AFE_3104DNA polymerase X family protein; Identified by match to protein family HMM PF00633; match to protein family HMM PF02811. (576 aa)
polIDNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (899 aa)
AFE_3032Identified by match to protein family HMM PF00483. (229 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (475 aa)
cysNCSulfate adenylate transferase, large subunit/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (604 aa)
cysD-1Sulfate adenylyltransferase, small subunit; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. (293 aa)
AFE_2960Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. (490 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (218 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (435 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (174 aa)
AFE_2721Lipoate-protein ligase A, putative; Identified by similarity to PIR:C70441; match to protein family HMM PF03099. (510 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (378 aa)
AFE_2545Lipoate-protein ligase A, putative; Identified by similarity to PIR:C70441; match to protein family HMM PF03099. (356 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (242 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (583 aa)
holCDNA polymerase III, chi subunit; Identified by similarity to SP:P28905; match to protein family HMM PF04364. (141 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (185 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (572 aa)
holBDNA polymerase III, delta prime subunit; Identified by similarity to SP:P28631. (333 aa)
dnaE2DNA polymerase III, alpha subunit, putative; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1015 aa)
AFE_1870Conserved hypothetical protein; Identified by similarity to GB:AAM40399.1. (440 aa)
AFE_1787Identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Belongs to the SUA5 family. (211 aa)
pcnBpolyA polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (477 aa)
AFE_1774Identified by match to protein family HMM PF01743; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (450 aa)
AFE_1751umuC protein; Identified by match to protein family HMM PF00817. (427 aa)
AFE_1674Sua5/YciO/YrdC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (328 aa)
dnaEDNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (1166 aa)
cdsAPhosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. (271 aa)
AFE_1406Kinase, pfkB family; Identified by similarity to GB:AAD49846.1; match to protein family HMM PF00294; match to protein family HMM TIGR02198. (316 aa)
AFE_1366Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by similarity to SP:P29956; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. (480 aa)
AFE_1072Conserved hypothetical protein; Identified by match to protein family HMM PF08808. (242 aa)
AFE_1046Conserved hypothetical protein. (147 aa)
glnDprotein-P-II uridylyltransferase; Identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF08335; match to protein family HMM TIGR01693. (862 aa)
rpoZDNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (91 aa)
AFE_0562yicC family protein; Identified by similarity to SP:P23839; match to protein family HMM PF03755; match to protein family HMM PF08340; match to protein family HMM TIGR00255. (287 aa)
ribFRiboflavin biosynthesis protein RibF; Identified by similarity to SP:P08391; match to protein family HMM PF01687; match to protein family HMM PF06574; match to protein family HMM TIGR00083; Belongs to the ribF family. (310 aa)
glnEGlutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (954 aa)
cysCSulfate adenylyltransferase, putative/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (557 aa)
selOConserved hypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family. (491 aa)
AFE_0515Hypothetical protein; Identified by glimmer; putative. (70 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (253 aa)
holADNA polymerase III, delta subunit; Identified by similarity to SP:P28630; match to protein family HMM PF06144; match to protein family HMM TIGR01128. (330 aa)
galUUTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to SP:Q05852; match to protein family HMM PF00483; match to protein family HMM TIGR01099. (298 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (248 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (690 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (237 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (339 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1384 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1362 aa)
AFE_0218Identified by match to protein family HMM PF01743; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (456 aa)
gmhA-2Phosphoheptose isomerase/cytidylyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. Belongs to the SIS family. GmhA subfamily. (358 aa)
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (365 aa)
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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