STRINGSTRING
AFE_1821 AFE_1821 iscS-1 iscS-1 AFE_3011 AFE_3011 glyA glyA bioF bioF hisC-2 hisC-2 gcvP gcvP AFE_0239 AFE_0239 metZ metZ aspC aspC bioA bioA AFE_1540 AFE_1540 hemL hemL hisC-1 hisC-1 AFE_0982 AFE_0982 iscS-2 iscS-2 AFE_1458 AFE_1458 serC serC iscS-3 iscS-3 AFE_0472 AFE_0472 argD argD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFE_1821Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR03538. (406 aa)
iscS-1Cysteine desulfurase; Identified by similarity to SP:O54055; match to protein family HMM PF00266. (393 aa)
AFE_30118-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202. (441 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (389 aa)
hisC-2Histidinol-phosphate aminotransferase; Identified by similarity to SP:P17731; match to protein family HMM PF00155; match to protein family HMM PF00266; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
gcvPGlycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (447 aa)
AFE_0239Aminotransferase, class II; Identified by similarity to SP:P23256; similarity to SP:Q08432; match to protein family HMM PF00155. (385 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (404 aa)
aspCAspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. (393 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
AFE_1540Aminotransferase, DegT/DnrJ/EryC1/StrS family; Identified by match to protein family HMM PF01041; Belongs to the DegT/DnrJ/EryC1 family. (380 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P48247; match to protein family HMM PF00202; match to protein family HMM TIGR00713. (430 aa)
hisC-1Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
AFE_0982Glycine dehydrogenase (decarboxylating), subunit 2. (508 aa)
iscS-2Cysteine desulfurase; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. (402 aa)
AFE_1458Pleiotropic regulatory protein, putative; Identified by similarity to SP:P15263; match to protein family HMM PF01041; match to protein family HMM PF01212; Belongs to the DegT/DnrJ/EryC1 family. (369 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
iscS-3Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (407 aa)
AFE_0472Aminotransferase, class I/II; Identified by similarity to GB:AAO58485.1; match to protein family HMM PF00155. (393 aa)
argDAcetylornithine aminotransferase; Identified by similarity to SP:P54752; match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (388 aa)
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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