STRINGSTRING
hdrA hdrA hdrB hdrB hdrC hdrC sfrA sfrA sfrB sfrB fdnG fdnG fdnH fdnH ppsA ppsA serA serA GSU1238 GSU1238 mdh mdh glyA glyA gpmA gpmA fbp fbp hprA hprA pfk-1 pfk-1 apgM apgM pfk-2 pfk-2 cooF cooF cooS cooS eno eno mvhS mvhS mvhL mvhL pta pta ackA ackA gpmI gpmI ackA-2 ackA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hdrAHeterodisulfide oxidoreductase, FAD-binding and iron-sulfur cluster-binding subunit A. (665 aa)
hdrBHeterodisulfide oxidoreductase, CCG domain pair-containing subunit B. (296 aa)
hdrCHeterodisulfide oxidoreductase, iron-sulfur cluster-binding subunit C. (194 aa)
sfrANADPH oxidoreductase, alpha subunit; NADPH-dependent Fe(3+) reductase. Probably involved in acetate metabolism and not in the reduction of Fe(3+) chelates. Unable to utilize NADH or formate as electron donors. Unlike formate dehydrogenases, contains no W, Mo or Se. Substrates are Fe(3+)- nitrilotriacetate >> Fe(3+)-citrate or Fe(3+)-EDTA > Fe(3+)- oxyhydroxide. Catalyzes also the reduction of NADP(+) with reduced methyl viologen as electron donor. No activity with menadione as electron acceptor. May be alternatively involved in transferring electrons from reduced ferredoxin to NADP(+) [...] (844 aa)
sfrBNADPH oxidoreductase, beta subunit; May catalyze the NADPH oxidation in the SfrAB NADPH-Fe(3+) oxidoreductase enzymatic complex. Probably involved in acetate metabolism and not in the reduction of Fe(3+) chelates. May serve as a major route for NADP regeneration. (672 aa)
fdnGPeriplasmically oriented, membrane-bound formate dehydrogenase, major subunit, selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1010 aa)
fdnHPeriplasmically oriented, membrane-bound formate dehydrogenase, iron-sulfur cluster-binding subunit. (277 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (805 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (542 aa)
GSU1238Iron-sulfur cluster-binding oxidoreductase. (149 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (317 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
gpmAPhosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa)
fbpFructose-1,6-bisphosphatase. (313 aa)
hprAHydroxypyruvate reductase, putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)
pfk-16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (363 aa)
apgMPhosphoglycerate mutase family protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (399 aa)
pfk-26-phosphofructokinase, ATP-dependent; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
cooFCarbon monoxide dehydrogenase-associated iron-sulfur cluster-binding oxidoreductase CooF. (197 aa)
cooSCarbon monoxide dehydrogenase, catalytic subunit. (640 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
mvhSMethyl viologen-reducing hydrogenase, small subunit. (316 aa)
mvhLMethyl viologen-reducing hydrogenase, large subunit. (473 aa)
ptaPhosphate acetyltransferase. (333 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (421 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa)
ackA-2Acetate kinase-related protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
Your Current Organism:
Geobacter sulfurreducens
NCBI taxonomy Id: 243231
Other names: G. sulfurreducens PCA, Geobacter sulfurreducens PCA, Geobacter sulfurreducens str. PCA, Geobacter sulfurreducens strain PCA
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.