STRINGSTRING
argB argB argD argD ilvE ilvE acnA acnA GSU1061 GSU1061 gltA gltA GSU1242 GSU1242 icd icd acnB acnB cimA cimA GSU1799 GSU1799 leuD leuD leuC leuC leuA leuA ilvC ilvC ilvN ilvN ilvB ilvB ilvD ilvD argJ argJ argA argA GSU2445 GSU2445 argC argC asd asd leuB leuB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (292 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa)
ilvEBranched-chain amino acid aminotransferase. (357 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (935 aa)
GSU1061Amino acid aminotransferase, putative. (398 aa)
gltACitrate synthase; Belongs to the citrate synthase family. (441 aa)
GSU1242Amino acid aminotransferase, putative. (399 aa)
icdIsocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family. (740 aa)
acnBAconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (847 aa)
cimACitramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. Makes part of the main pathway for isoleucine biosynthesis in G.sulfurreducens, i.e. the citramalate-dependent pathway; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa)
GSU1799Aspartate 4-kinase; Belongs to the aspartokinase family. (405 aa)
leuDIsopropylmalate/citramalate isomerase, small subunit; Belongs to the LeuD family. (175 aa)
leuCIsopropylmalate/citramalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (427 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa)
ilvCKetol-acid reductoisomerase, class I; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
ilvNAcetolactate synthase, small subunit. (163 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type. (566 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
argJOrnithine:glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (393 aa)
argAN-acetylglutamate synthase. (149 aa)
GSU2445Aconitate hydratase, putative. (645 aa)
argCN-acetyl-glutamyl-5-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
asdAspartate-4-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa)
leuB3-isopropylmalate/3-methylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (362 aa)
Your Current Organism:
Geobacter sulfurreducens
NCBI taxonomy Id: 243231
Other names: G. sulfurreducens PCA, Geobacter sulfurreducens PCA, Geobacter sulfurreducens str. PCA, Geobacter sulfurreducens strain PCA
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.