STRINGSTRING
fdhB fdhB MJ_0006 MJ_0006 frhD frhD frhG frhG frhB frhB MJ_0034 MJ_0034 MJ_0035 MJ_0035 mfnA mfnA mrtB mrtB mrtG mrtG mrtA mrtA MJ_0107 MJ_0107 mrtD mrtD MJ_0173 MJ_0173 MJ_0199 MJ_0199 MJ_0201 MJ_0201 MJ_0202 MJ_0202 dmrX dmrX MJ_0226.1 MJ_0226.1 MJ_0226.2 MJ_0226.2 MJ_0227 MJ_0227 MJ_0253 MJ_0253 MJ_0271 MJ_0271 MJ_0272 MJ_0272 MJ_0301 MJ_0301 trx trx ftr ftr MJ_0447 MJ_0447 MJ_0448 MJ_0448 MJ_0449 MJ_0449 mfnE mfnE MJ_0532 MJ_0532 MJ_0533 MJ_0533 MJ_0534 MJ_0534 MJ_0565 MJ_0565 MJ_0566 MJ_0566 MJ_0567 MJ_0567 MJ_0568 MJ_0568 MJ_0578 MJ_0578 MJ_0579 MJ_0579 MJ_0580 MJ_0580 MJ_0581 MJ_0581 MJ_0582 MJ_0582 MJ_0583 MJ_0583 MJ_0584 MJ_0584 MJ_0585 MJ_0585 mptN mptN MJ_0658 MJ_0658 mfnC mfnC MJ_0725 MJ_0725 MJ_0726 MJ_0726 MJ_0727 MJ_0727 MJ_0730 MJ_0730 MJ_0731 MJ_0731 MJ_0732 MJ_0732 MJ_0733 MJ_0733 MJ_0734 MJ_0734 MJ_0735 MJ_0735 MJ_0736 MJ_0736 MJ_0737 MJ_0737 MJ_0738 MJ_0738 MJ_0739 MJ_0739 MJ_0740 MJ_0740 MJ_0741 MJ_0741 MJ_0742 MJ_0742 hdrB1 hdrB1 hdrC1 hdrC1 MJ_0745 MJ_0745 MJ_0746 MJ_0746 MJ_0747 MJ_0747 fprA fprA MJ_0749 MJ_0749 MJ_0750 MJ_0750 MJ_0751 MJ_0751 MJ_0752 MJ_0752 MJ_0753 MJ_0753 MJ_0754 MJ_0754 MJ_0755 MJ_0755 MJ_0756 MJ_0756 MJ_0757 MJ_0757 MJ_0758 MJ_0758 MJ_0759 MJ_0759 MJ_0760 MJ_0760 MJ_0761 MJ_0761 MJ_0762 MJ_0762 MJ_0763 MJ_0763 MJ_0764 MJ_0764 MJ_0766 MJ_0766 MJ_0767 MJ_0767 hmd hmd mfnD mfnD mfnF mfnF mcrB mcrB mcrD mcrD mcrC mcrC mcrG mcrG mcrA mcrA mtrE mtrE mtrD mtrD mtrC mtrC mtrB mtrB mtrA mtrA mtrF mtrF mtrG mtrG mtrH mtrH hdrB2 hdrB2 hdrC2 hdrC2 mtd mtd MJ_1036 MJ_1036 mfnB mfnB fwdE fwdE fwdF fwdF fwdG fwdG fwdD fwdD fwdA fwdA MJ_1170 MJ_1170 fwdC fwdC vhuD vhuD vhuG vhuG vhuA vhuA vhuB vhuB MJ_1240 MJ_1240 MJ_1242 MJ_1242 MJ_1243 MJ_1243 MJ_1244 MJ_1244 MJ_1245 MJ_1245 MJ_1349 MJ_1349 MJ_1350 MJ_1350 MJ_1351 MJ_1351 MJ_1356 MJ_1356 MJ_1511 MJ_1511 mer mer MJ_1536 MJ_1536 mch mch MJ_1662 MJ_1662
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fdhBFormate dehydrogenase, beta subunit; Catalyzes the oxidation of formate; Belongs to the FrhB family. (379 aa)
MJ_0006Formate dehydrogenase, alpha subunit; Similar to GB:J02581 SP:P06131 PID:149708 percent identity: 41.56; identified by sequence similarity; putative; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (378 aa)
frhDCoenzyme F420-reducing hydrogenase, delta subunit (frcD); Similar to GB:X61202 PID:44706 percent identity: 65.70; identified by sequence similarity; putative; Belongs to the peptidase A31 family. (183 aa)
frhGCoenzyme F420-reducing hydrogenase, gamma subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. (230 aa)
frhBCoenzyme F420-reducing hydrogenase, beta subunit (frhB); Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Belongs to the FrhB family. (287 aa)
MJ_0034Conserved hypothetical protein; Similar to PID:726070 GB:AE000666 percent identity: 23.57; identified by sequence similarity; putative; Belongs to the UPF0051 (ycf24) family. (316 aa)
MJ_0035ABC transporter subunit; Similar to SP:P48255 percent identity: 37.61; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (250 aa)
mfnAGroup II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. (396 aa)
mrtBMethyl coenzyme M reductase II, subunit beta (mrtB); Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (447 aa)
mrtGMethyl coenzyme M reductase II, subunit gamma (mtrG); Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (266 aa)
mrtAMethyl coenzyme M reductase II, subunit alpha (mtrA); Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (552 aa)
MJ_0107Dihydropteroate synthase; Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate. (525 aa)
mrtDMethyl coenzyme M reductase II, operon protein D (mtrD); Similar to GB:X70765 PID:488816 percent identity: 53.12; identified by sequence similarity; putative. (167 aa)
MJ_0173Conserved hypothetical protein; Putative transcriptional regulator. (157 aa)
MJ_0199Ferredoxin; Similar to SP:P21305 percent identity: 74.58; identified by sequence similarity; putative. (65 aa)
MJ_0201Lipoprotein B (lppB); Similar to GB:L42023 SP:P44832 PID:1005617 PID:1220788 PID:1204952 percent identity: 27.82; identified by sequence similarity; putative. (160 aa)
MJ_0202Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 40.14; identified by sequence similarity; putative. (304 aa)
dmrX4Fe-4S iron-sulfur protein; Involved in the biosynthesis of tetrahydromethanopterin, a coenzyme used in methanogenesis. Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT). Ferredoxin may serve as an electron donor. (246 aa)
MJ_0226.1Hypothetical protein; Brute Force ORF; identified by GeneMark; putative; M. jannaschii predicted coding region MJ0226.1. (193 aa)
MJ_0226.2Hypothetical protein; Brute Force ORF; identified by GeneMark; putative; M. jannaschii predicted coding region MJ0226.2. (122 aa)
MJ_0227Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 40.07; identified by sequence similarity; putative. (308 aa)
MJ_0253Coenzyme F420-reducing hydrogenase, delta subunit (frcD); Similar to GB:X61201 PID:44702 percent identity: 45.45; identified by sequence similarity; putative; Belongs to the peptidase A31 family. (154 aa)
MJ_0271Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0271. (180 aa)
MJ_0272Repressor protein, putative (yorfE); Similar to GP:1536960 percent identity: 40.32; identified by sequence similarity; putative. (79 aa)
MJ_0301Conserved hypothetical protein; Catalyzes the condensation of 6-hydroxymethyl-7,8- dihydropterin pyrophosphate (DHPP) with 4-(beta-D-ribofuranosyl)- aminobenzene-5'-phosphate (beta-RFA-P) to form 7,8-dihydropterin-6- methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate, a precursor in the biosynthesis of 5,6,7,8-tetrahydromethanopterin (H4MPT). To a lesser extent, is able to condense beta-RFA-P with another arylamine, 1-(4-aminophenyl)-1-deoxy-D-ribitol (APDR), to form 7,8-dihydropterin- 6-methyl-1-(4-aminophenyl)-1-deoxy-D-ribitol. Dephosphorylated beta- RFA-P is not a substrate; [...] (294 aa)
trxThioredoxin (trx); Acts to maintain redox homeostasis; functions as a protein disulfide reductase. (85 aa)
ftrFormylmethanofuran:tetrahydromethanopterin formyltransferase (ftr); Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (301 aa)
MJ_0447Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0447. (161 aa)
MJ_0448Conserved hypothetical protein; Similar to PID:577190 percent identity: 29.38; identified by sequence similarity; putative; Belongs to the metallo-beta-lactamase superfamily. (256 aa)
MJ_0449Hypothetical transmembrane protein yeaB; Similar to GP:1708640 percent identity: 31.05; identified by sequence similarity; putative. (283 aa)
mfnEDelta 1-pyrroline-5-carboxylate synthetase; Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1- P) and ATP. In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP. (216 aa)
MJ_0532Bacteriochlorophyll synthase 43 kDa subunit (chlP); Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (391 aa)
MJ_0533Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (56 aa)
MJ_0534Flavoprotein (fprA); Similar to PID:687617 percent identity: 34.10; identified by sequence similarity; putative. (391 aa)
MJ_0565Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0565. (147 aa)
MJ_0566Ferrous iron transport protein B (feoB); Probable transporter of a GTP-driven Fe(2+) uptake system, might be able to transport Fe(2+) into or out of the cell (Probable). Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (668 aa)
MJ_0567Conserved hypothetical protein; Might be involved in Fe(2+) ion uptake (By similarity). (82 aa)
MJ_0568Iron dependent repressor; Similar to GP:1777937 percent identity: 32.48; identified by sequence similarity; putative; Belongs to the DtxR/MntR family. (125 aa)
MJ_0578Iron-sulfer cluster binding protein; Similar to SP:P80168 percent identity: 49.02; identified by sequence similarity; putative. (276 aa)
MJ_0579Cell division inhibitor minD-like; Similar to GB:M95582 SP:Q01464 GB:M96343 PID:142859 PID:143216 percent identity: 31.79; identified by sequence similarity; putative; To M.jannaschii MJ0578. (269 aa)
MJ_0580Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 44.55; identified by sequence similarity; putative. (118 aa)
MJ_0581Conserved hypothetical protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase (By similarity). Has low thioredoxin activity in vitro (By similarity). (86 aa)
MJ_0582Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 34.74; identified by sequence similarity; putative; To M.jannaschii MJ0766. (128 aa)
MJ_0583Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0583. (57 aa)
MJ_0584Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 37.98; identified by sequence similarity; putative. (365 aa)
MJ_0585Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0585. (205 aa)
mptNRibosomal protein S6 modification protein 1 (rimK); Catalyzes the ATP or GTP-dependent addition of one L- glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin. (291 aa)
MJ_0658Hypothetical protein; Invalid gene; identified by GeneMark; putative; M. jannaschii predicted coding region MJ0658; To M.thermoautotrophicum MTH238. (318 aa)
mfnCAspartate aminotransferase (aspB2); Catalyzes the transamination reaction between 4- (hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) and alanine to produce pyruvate and 5-(aminomethyl)-3-furanmethanol phosphate (F1- P), the precursor for the furan moiety in methanofuran. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (370 aa)
MJ_0725Coenzyme F420-reducing hydrogenase, beta subunit; Similar to GB:J02914 SP:P19499 PID:149718 GB:AE000666 percent identity: 42.24; identified by sequence similarity; putative; Belongs to the FrhB family. (261 aa)
MJ_0726Coenzyme F420-reducing hydrogenase, gamma subunit; Similar to GB:X61201 PID:809730 SP:Q00393 percent identity: 43.53; identified by sequence similarity; putative; Belongs to the FrhG family. (216 aa)
MJ_0727Coenzyme F420-reducing hydrogenase, alpha subunit; Similar to GB:J02914 SP:P19496 PID:551889 GB:AE000666 percent identity: 27.08; identified by sequence similarity; putative. (298 aa)
MJ_0730DNA/pantothenate metabolism flavoprotein-like; Similar to GB:L10328 SP:P24285 PID:290489 GB:U00096 PID:1790070 percent identity: 31.20; identified by sequence similarity; putative; To M.jannaschii MJ0208. (186 aa)
MJ_0731Iron-sulfur flavoprotein (isf); Redox-active protein probably involved in electron transport. Belongs to the SsuE family. Isf subfamily. (198 aa)
MJ_0732Flavoprotein (fprA); Similar to PID:687617 percent identity: 40.62; identified by sequence similarity; putative. (393 aa)
MJ_0733Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0733. (121 aa)
MJ_0734Rubrerythrin (rr); May provide oxidative stress protection via catalytic reduction of intracellular hydrogen peroxide. (204 aa)
MJ_0735Rubredoxin 1 (rd1); Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity). (80 aa)
MJ_0736Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (222 aa)
MJ_0737Rubredoxin-like non-heme iron protein; Similar to SP:P19500 percent identity: 32.56; identified by sequence similarity; putative. (61 aa)
MJ_0738Conserved hypothetical protein; Similar to GB:X69112 PID:44585 GB:AE000666 percent identity: 41.82; identified by sequence similarity; putative. (90 aa)
MJ_0739Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0739; Belongs to the M.jannaschii MJ0150/MJ0739/MJ0745/MJ1460/MJ1642 family. (151 aa)
MJ_0740Rubredoxin 2 (rd2); Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity). (55 aa)
MJ_0741Desulfoferrodoxin, putative (rbo); Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide. (116 aa)
MJ_0742Conserved hypothetical protein; Similar to GB:L42023 PID:1006306 PID:1221170 PID:1205303 SP:Q57498 percent identity: 29.55; identified by sequence similarity; putative; To M.jannaschii MJ1511. (104 aa)
hdrB1Heterodisulfide reductase, subunit B1 (hdrB1); Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (294 aa)
hdrC1Heterodisulfide reductase, subunit C (hdrC); Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B); Belongs to the HdrC family. (194 aa)
MJ_0745Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0745; Belongs to the M.jannaschii MJ0150/MJ0739/MJ0745/MJ1460/MJ1642 family. (181 aa)
MJ_0746Conserved hypothetical protein; Similar to PID:710357 GB:AE000666 percent identity: 70.59; identified by sequence similarity; putative. (141 aa)
MJ_0747Hemerythrin sipunculid; Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen- binding site contains two iron atoms; Belongs to the hemerythrin family. (169 aa)
fprAFlavoprotein (fpaA); Probably functions as an electron acceptor for a hydrogenase; however there is an uncharacterized intermediate between the hydrogenase and flavoprotein A; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (416 aa)
MJ_0749Conserved hypothetical protein; Similar to GP:1787226 percent identity: 31.17; identified by sequence similarity; putative. (246 aa)
MJ_0750Ferredoxin-type protein (napH); Similar to SP:P33934 PID:405929 GB:U00096 PID:1788532 percent identity: 25.27; identified by sequence similarity; putative. (238 aa)
MJ_0751Conserved hypothetical protein; Similar to GP:1707749 percent identity: 33.56; identified by sequence similarity; putative; In the N-terminal section; belongs to the transposase 2 family. (278 aa)
MJ_0752Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0752; To M.jannaschii MJ0857 N-terminal region. (76 aa)
MJ_0753Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0753. (210 aa)
MJ_0754Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0754. (185 aa)
MJ_0755N-acetylmuramoyl-L-alanine amidase; Similar to GB:D10388 SP:Q02114 GB:M81324 PID:142806 PID:143159 percent identity: 34.19; identified by sequence similarity; putative. (342 aa)
MJ_0756Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0756. (136 aa)
MJ_0757Conserved hypothetical protein; Is able to catalyze the biosynthesis of dTMP using dUMP, tetrahydrofolate and formaldehyde in vitro, i.e. a reaction equivalent to that catalyzed by bacterial thymidylate synthases (EC 2.1.1.45). However, M.jannaschii like most methanogenic Archaea lacks folates, thus the physiological cosubstrate is unknown but is likely one of the non-methylated methanopterin biosynthetic intermediates. (260 aa)
MJ_0758Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0758. (159 aa)
MJ_0759Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 33.02; identified by sequence similarity; putative. (118 aa)
MJ_0760Conserved hypothetical protein; Similar to SP:P54436 PID:1303708 GB:AL009126 percent identity: 30.26; identified by sequence similarity; putative. (275 aa)
MJ_0761Conserved hypothetical protein; Similar to GB:D26185 SP:P37545 PID:467428 GB:AL009126 percent identity: 31.62; identified by sequence similarity; putative. (251 aa)
MJ_0762C4-dicarboxylate transporter (mae1); Similar to SP:P50537 percent identity: 24.34; identified by sequence similarity; putative. (342 aa)
MJ_0763Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0763. (121 aa)
MJ_0764Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0764. (116 aa)
MJ_0766Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0766; To M.jannaschii MJ0582. (66 aa)
MJ_0767Conserved hypothetical protein; Similar to SP:P28910 PID:147625 PID:466617 GB:U00096 PID:1789892 percent identity: 23.48; identified by sequence similarity; putative; Belongs to the transcriptional regulatory CopG/NikR family. (135 aa)
hmdH2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenease (hmd); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (358 aa)
mfnDConserved hypothetical protein; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro. (308 aa)
mfnFConserved hypothetical protein; Catalyzes the condensation between 5-(aminomethyl)-3- furanmethanol diphosphate (F1-PP) and gamma-glutamyltyramine to produce APMF-Glu. (330 aa)
mcrBMethyl coenzyme M reductase I, subunit beta (mcrB); Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (447 aa)
mcrDMethyl coenzyme M reductase I, operon protein D (mcrD); Similar to GB:M16893 SP:P07957 PID:150056 percent identity: 60.38; identified by sequence similarity; putative. (164 aa)
mcrCMethyl coenzyme M reductase I, operon protein C (mcrC); Similar to GB:M16893 SP:P07960 PID:150057 percent identity: 82.74; identified by sequence similarity; putative. (200 aa)
mcrGMethyl coenzyme M reductase I, subunit gamma (mcrG); Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (260 aa)
mcrAMethyl coenzyme M reductase I, subunit alpha (mcrA); Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (553 aa)
mtrEN5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit E (mtrE); Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (303 aa)
mtrDN5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit D (mtrD); Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (230 aa)
mtrCN5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit C (mrtC); Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (265 aa)
mtrBN5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit B (mrtB); Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (103 aa)
mtrAN5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit A (mtrA); Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (245 aa)
mtrFN5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit F (mtrF); Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (68 aa)
mtrGN5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit G (mtrG); Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (84 aa)
mtrHN5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit H (mtrH); Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (333 aa)
hdrB2Heterodisulfide reductase, subunit B2 (hdrB2); Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (295 aa)
hdrC2Heterodisulfide reductase, subunit C2 (hdrC2); Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B); Belongs to the HdrC family. (186 aa)
mtdN5,N10-methylene-tetrahydromethanopterin dehydrogenase (mtd); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (277 aa)
MJ_1036Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1036. (233 aa)
mfnBConserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (235 aa)
fwdEFormylmethanofuran dehydrogenase, subunit E (tungsten) (fwdE); Similar to PID:871458 GB:AE000666 PID:1890206 percent identity: 41.22; identified by sequence similarity; putative. (146 aa)
fwdFFormylmethanofuran dehydrogenase, subunit F (tungsten) (fwdF); Similar to PID:871459 GB:AE000666 PID:1890207 percent identity: 48.34; identified by sequence similarity; putative. (355 aa)
fwdGFormylmethanofuran dehydrogenase, subunit G (tungsten) (fwdG); Similar to PID:871460 GB:AE000666 PID:1890208 percent identity: 59.74; identified by sequence similarity; putative. (82 aa)
fwdDFormylmethanofuran dehydrogenase, subunit D (tungsten) (fwdD); Similar to PID:871461 GB:AE000666 PID:1890209 percent identity: 58.54; identified by sequence similarity; putative. (133 aa)
fwdAFormylmethanofuran dehydrogenase, subunit A (tungsten) (fwdA); Similar to PID:871462 GB:AE000666 PID:1890210 percent identity: 68.95; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family. (567 aa)
MJ_1170Conserved hypothetical protein; Similar to GB:M82881 SP:P33382 PID:149648 percent identity: 42.17; identified by sequence similarity; putative; Belongs to the UPF0145 family. Highly divergent. (89 aa)
fwdCFormylmethanofuran dehydrogenase, subunit C (tungsten) (fwdC); Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile. Belongs to the FwdC/FmdC family. (273 aa)
vhuDvhuD protein; Similar to GB:X61204 PID:44797 percent identity: 77.78; identified by sequence similarity; putative; Belongs to the MvhD/VhuD family. (44 aa)
vhuGMethylviologen-reducing hydrogenase, gamma chain (vhuG); Similar to GB:X61204 PID:44798 PID:1747407 percent identity: 71.13; identified by sequence similarity; putative. (288 aa)
vhuAMethylviologen-reducing hydrogenase, alpha chain (vhuA); Similar to GB:X61204 PID:44799 PID:1747408 percent identity: 77.03; identified by sequence similarity; putative. (418 aa)
vhuBPolyferredoxin (mvhB); Similar to GB:M34016 PID:149806 percent identity: 48.04; identified by sequence similarity; putative. (394 aa)
MJ_1240Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1240. (97 aa)
MJ_1242Methyl coenzyme M reductase system, component A2 (atwA); Similar to GB:L11748 PID:293151 PID:385924 GB:AE000666 percent identity: 60.26; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (539 aa)
MJ_1243Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 38.71; identified by sequence similarity; putative; Belongs to the UPF0251 family. (123 aa)
MJ_1244Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 50.00; identified by sequence similarity; putative; To M.jannaschii MJ1245 and M.thermoautotrophicum MTH1110. (108 aa)
MJ_1245Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1245; To M.jannaschii MJ1244 and M.thermoautotrophicum MTH1110. (112 aa)
MJ_1349Coenzyme F420-reducing hydrogenase, beta subunit; Similar to GB:X61201 PID:809731 SP:Q00391 percent identity: 35.74; identified by sequence similarity; putative; Belongs to the FrhB family. (360 aa)
MJ_1350Formylmethanofuran dehydrogenase, subunt C (tungsten); Similar to GB:AE000782 percent identity: 46.59; identified by sequence similarity; putative; Belongs to the FwdC/FmdC family. (261 aa)
MJ_1351Glutamate synthase (gltB); Similar to GB:M18747 SP:P09831 GB:L20253 GB:M33743 GB:M68876 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the glutamate synthase family. (510 aa)
MJ_1356Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1356; To M.jannaschii MJ1461. (189 aa)
MJ_1511Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 40.43; identified by sequence similarity; putative. (107 aa)
merN5,N10-methylene-tetrahydromethanopterin reductase (mer); Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (331 aa)
MJ_1536Thioredoxin reductase (trxB); Similar to GB:U02197 GB:L43967 SP:P47348 PID:1045780 percent identity: 38.93; identified by sequence similarity; putative. (301 aa)
mchN5,N10-methenyl-tetrahydromethanopterin cyclohydrolase (mch); Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (323 aa)
MJ_1662Methyl coenzyme M reductase system, component A2-like; Similar to GB:L11748 PID:293151 PID:385924 GB:AE000666 percent identity: 37.07; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (555 aa)
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.