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mfnA mfnA MJ_0107 MJ_0107 dmrX dmrX ftr ftr mfnE mfnE mptN mptN MJ_0658 MJ_0658 mfnC mfnC hmd hmd mfnD mfnD mfnF mfnF mtd mtd mfnB mfnB fwdE fwdE fwdF fwdF fwdG fwdG fwdD fwdD fwdA fwdA MJ_1170 MJ_1170 fwdC fwdC mch mch
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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mfnAGroup II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. (396 aa)
MJ_0107Dihydropteroate synthase; Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate. (525 aa)
dmrX4Fe-4S iron-sulfur protein; Involved in the biosynthesis of tetrahydromethanopterin, a coenzyme used in methanogenesis. Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT). Ferredoxin may serve as an electron donor. (246 aa)
ftrFormylmethanofuran:tetrahydromethanopterin formyltransferase (ftr); Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (301 aa)
mfnEDelta 1-pyrroline-5-carboxylate synthetase; Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1- P) and ATP. In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP. (216 aa)
mptNRibosomal protein S6 modification protein 1 (rimK); Catalyzes the ATP or GTP-dependent addition of one L- glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin. (291 aa)
MJ_0658Hypothetical protein; Invalid gene; identified by GeneMark; putative; M. jannaschii predicted coding region MJ0658; To M.thermoautotrophicum MTH238. (318 aa)
mfnCAspartate aminotransferase (aspB2); Catalyzes the transamination reaction between 4- (hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) and alanine to produce pyruvate and 5-(aminomethyl)-3-furanmethanol phosphate (F1- P), the precursor for the furan moiety in methanofuran. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (370 aa)
hmdH2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenease (hmd); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (358 aa)
mfnDConserved hypothetical protein; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro. (308 aa)
mfnFConserved hypothetical protein; Catalyzes the condensation between 5-(aminomethyl)-3- furanmethanol diphosphate (F1-PP) and gamma-glutamyltyramine to produce APMF-Glu. (330 aa)
mtdN5,N10-methylene-tetrahydromethanopterin dehydrogenase (mtd); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (277 aa)
mfnBConserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (235 aa)
fwdEFormylmethanofuran dehydrogenase, subunit E (tungsten) (fwdE); Similar to PID:871458 GB:AE000666 PID:1890206 percent identity: 41.22; identified by sequence similarity; putative. (146 aa)
fwdFFormylmethanofuran dehydrogenase, subunit F (tungsten) (fwdF); Similar to PID:871459 GB:AE000666 PID:1890207 percent identity: 48.34; identified by sequence similarity; putative. (355 aa)
fwdGFormylmethanofuran dehydrogenase, subunit G (tungsten) (fwdG); Similar to PID:871460 GB:AE000666 PID:1890208 percent identity: 59.74; identified by sequence similarity; putative. (82 aa)
fwdDFormylmethanofuran dehydrogenase, subunit D (tungsten) (fwdD); Similar to PID:871461 GB:AE000666 PID:1890209 percent identity: 58.54; identified by sequence similarity; putative. (133 aa)
fwdAFormylmethanofuran dehydrogenase, subunit A (tungsten) (fwdA); Similar to PID:871462 GB:AE000666 PID:1890210 percent identity: 68.95; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family. (567 aa)
MJ_1170Conserved hypothetical protein; Similar to GB:M82881 SP:P33382 PID:149648 percent identity: 42.17; identified by sequence similarity; putative; Belongs to the UPF0145 family. Highly divergent. (89 aa)
fwdCFormylmethanofuran dehydrogenase, subunit C (tungsten) (fwdC); Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile. Belongs to the FwdC/FmdC family. (273 aa)
mchN5,N10-methenyl-tetrahydromethanopterin cyclohydrolase (mch); Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (323 aa)
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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