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apgM2 apgM2 MJ_0033 MJ_0033 MJ_0092 MJ_0092 MJ_0108 MJ_0108 cdhE cdhE cdhD cdhD MJ_0146 MJ_0146 cdhC1 cdhC1 cdhA cdhA cdhB cdhB MJ_0155 MJ_0155 cdhC2 cdhC2 MJ_0198 MJ_0198 sucC sucC eno eno MJ_0264 MJ_0264 MJ_0265 MJ_0265 porB porB porA porA porD porD porC porC korA korA fbp fbp mdh mdh korC korC korB korB ppsA ppsA MJ_0590 MJ_0590 MJ_0617 MJ_0617 pgk pgk pdxS pdxS MJ_0679 MJ_0679 rpe rpe MJ_0681 MJ_0681 MJ_0685 MJ_0685 cooS cooS MJ_0823 MJ_0823 tal tal serA serA gap gap MJ_1185 MJ_1185 pycA pycA pycB pycB sucD sucD MJ_1294 MJ_1294 tpiA tpiA MJ_1585 MJ_1585 rpiA rpiA pfkC pfkC pgi pgi apgM1 apgM1 pdxT pdxT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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apgM2BcpC phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (428 aa)
MJ_0033Succinate dehydrogenase, flavoprotein subunit (sdhA); Similar to GP:1524302 percent identity: 41.63; identified by sequence similarity; putative. (539 aa)
MJ_0092Heterodisulfide reductase, subunit D (hdrD); Similar to GP:1890198 percent identity: 31.87; identified by sequence similarity; putative; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (489 aa)
MJ_0108Pyruvate kinase; Similar to GB:D13095 SP:Q02499 GB:X57859 PID:285623 percent identity: 38.82; identified by sequence similarity; putative. (447 aa)
cdhEacetyl-CoA decarbonylase/synthase, subunit gamma (cdhE); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (488 aa)
cdhDacetyl-CoA decarbonylase/synthase, subunit delta (cdhD); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (405 aa)
MJ_01462-ketoglutarate ferredoxin oxidoreductase, subunit delta (korD); Similar to GB:M63654 SP:P23481 PID:147018 GB:U00096 PID:1788826 percent identity: 36.92; identified by sequence similarity; putative. (69 aa)
cdhC1Carbon monoxide dehydrogenase, subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (748 aa)
cdhAacetyl-CoA decarbonylase/synthase, subunit alpha (cdhA); Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (774 aa)
cdhBacetyl-CoA decarbonylase/synthase, subunit epsilon (cdhB); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family. (146 aa)
MJ_0155Formate dehydrogenase, iron-sulfur subunit; Similar to SP:P27273 PID:48508 percent identity: 41.67; identified by sequence similarity; putative. (151 aa)
cdhC2acetyl-CoA decarbonylase/synthase, subunit beta (cdhC); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (469 aa)
MJ_0198Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0198. (314 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (364 aa)
enoEnolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
MJ_0264Carbon monoxide dehydrogenase, iron sulfur subunit CooF-1 (cooF1); Similar to GB:M90421 SP:P31894 PID:1171263 PID:1498747 percent identity: 36.04; identified by sequence similarity; putative. (153 aa)
MJ_0265Carbon monoxide dehydrogenase, iron sulfur subunit CooF-1 (cooF2); Similar to GB:M90421 SP:P31894 PID:1171263 PID:1498747 percent identity: 39.10; identified by sequence similarity; putative. (166 aa)
porBPyruvate ferredoxin oxidoreductase, subunit beta (porB); Similar to PID:1197364 percent identity: 58.89; identified by sequence similarity; putative. (298 aa)
porAPyruvate ferredoxin oxidoreductase, subunit alpha (porA); Similar to PID:1197363 percent identity: 57.33; identified by sequence similarity; putative. (389 aa)
porDPyruvate ferredoxin oxidoreductase, subunit delta (porD); Similar to GP:1197362 percent identity: 58.82; identified by sequence similarity; putative. (86 aa)
porCPyruvate ferredoxin oxidoreductase, subunit gamma (porG); Similar to PID:1197358 percent identity: 63.22; identified by sequence similarity; putative. (178 aa)
korA2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA); Similar to GB:X64521 PID:43498 percent identity: 44.24; identified by sequence similarity; putative. (366 aa)
fbpConserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (389 aa)
mdhL-lactate dehydrogenase EGAD|7256|705; Catalyzes the reversible oxidation of (S)-malate and (S)- sulfolactate to oxaloacetate and sulfopyruvate, respectively. Can use both NADH and NADPH, although activity is higher with NADPH. Oxidation of (S)-sulfolactate is observed only in the presence of NADP(+). Can also oxidize tartrate. Cannot reduce pyruvate, nor alpha-ketoglutarate. Belongs to the LDH/MDH superfamily. (313 aa)
korC2-ketoglutarate ferredoxin oxidoreductase, subunit gamma (korG); Similar to PID:1197358 percent identity: 32.00; identified by sequence similarity; putative. (187 aa)
korB2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB); Similar to GB:X64521 PID:43499 percent identity: 40.43; identified by sequence similarity; putative. (270 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. (1188 aa)
MJ_0590Conserved hypothetical protein; Catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can also use butyryl-CoA, but not phenylacetyl-CoA. Cannot catalyze the reverse reaction. In the N-terminal section; belongs to the acetate CoA ligase alpha subunit family. (704 aa)
MJ_0617Tartrate dehydratse, subunit beta (ttdB); Similar to PID:882585 GB:U00096 PID:1789443 percent identity: 42.70; identified by sequence similarity; putative; Belongs to the class-I fumarase family. (195 aa)
pgkPhosphoglycerate kinase (pgk); Similar to GB:M55529 SP:P20971 PID:149808 percent identity: 56.76; identified by sequence similarity; putative; Belongs to the phosphoglycerate kinase family. (417 aa)
pdxSEthylene-inducible protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (330 aa)
MJ_0679Transketolase'; Similar to GB:M86521 SP:P29401 percent identity: 37.25; identified by sequence similarity; putative; Belongs to the transketolase family. (316 aa)
rpePentose-5-phosphate-3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (234 aa)
MJ_0681Transketolase; Similar to GB:M86521 SP:P29401 percent identity: 34.15; identified by sequence similarity; putative. (274 aa)
MJ_0685Nitrogenase reductase (nifH2); Similar to SP:P22548 GB:M21537 SP:P00456 SP:P09552 SP:P09554 percent identity: 33.62; identified by sequence similarity; putative; To M.jannaschii MJ0084 and MJ0823. (253 aa)
cooSCarbon monoxide dehydrogenase, catalytic subunit (cooS); CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH). (624 aa)
MJ_0823CODH nickel-insertion accessory protein CooC (cooC); Similar to GP:1498749 percent identity: 45.65; identified by sequence similarity; putative; To M.jannaschii MJ0084 and MJ0685. (257 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
serAPhosphoglycerate dehydrogenase (serA); Similar to GB:L09228 SP:P35136 PID:1146196 PID:410116 GB:AL009126 percent identity: 42.02; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (524 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; Similar to SP:P10618 PID:149792 percent identity: 60.00; identified by sequence similarity; putative. (343 aa)
MJ_1185Putative aldehyde ferredoxin oxidoreductase (aor); Similar to PID:736274 percent identity: 26.51; identified by sequence similarity; putative; Belongs to the AOR/FOR family. (622 aa)
pycABiotin carboxylase (accC); Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (501 aa)
pycBOxaloacetate decarboxylase alpha chain (oadA); Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (567 aa)
sucDsuccinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
MJ_1294Tartrate dehydratase, subunit alpha (ttdA); Similar to GB:L14781 SP:P05847 PID:347084 PID:882584 PID:1789442 percent identity: 32.86; identified by sequence similarity; putative. (285 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). (219 aa)
MJ_1585Conserved hypothetical protein; Catalyzes the transaldolisation of either fructose-1-P or fructose-1,6-bisphosphate with methylglyoxal to produce 6-deoxy-5- ketofructose-1-phosphate (DKFP). Also catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone- phosphate) with glyceraldehyde 3-phosphate (G3P or GAP) to produce fructose 1,6-bisphosphate (FBP). (310 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (226 aa)
pfkCHypothetical protein; Catalyzes the phosphorylation of fructose 6-phosphate and D- glucose to fructose 1,6-bisphosphate and D-glucose 6-phosphate, respectively, using ADP as the phosphate donor; Belongs to the carbohydrate kinase PfkC family. (462 aa)
pgiGlucose-6-phosphate isomerase; Catalyzes the isomerization of glucose-6-P to fructose-6-P. (401 aa)
apgM1Phosphonopyruvate decarboxylase (bcpC); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (411 aa)
pdxTConserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (186 aa)
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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