STRINGSTRING
trm5b trm5b trm4 trm4 MJ_0046 MJ_0046 trmI trmI MJ_0421 MJ_0421 trm14 trm14 nep1 nep1 flpA flpA trmG10 trmG10 trm1 trm1 rsmA rsmA mjaVIM mjaVIM rlmE rlmE MJ_1385 MJ_1385 mjaIIM mjaIIM trmJ trmJ taw3 taw3 taw2 taw2 trmY trmY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trm5bConserved hypothetical protein; Specifically methylates the N1 position of guanosine-37 in various tRNAs. (336 aa)
trm4Proliferating-cell nucleolar antigen, FMU/NOL1/NOP2 family; Catalyzes AdoMet-dependent formation of m5C in tRNA. Cytidine residue at either position 40 or position 48 is likely to be methylated; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (274 aa)
MJ_0046Conserved hypothetical protein; Similar to GB:L42023 SP:P45106 PID:1007078 PID:1221325 PID:1205444 percent identity: 24.82; identified by sequence similarity; putative; Belongs to the methyltransferase superfamily. (261 aa)
trmIL-isoaspartyl protein carboxyl methyltransferase isolog (pimT); Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. (282 aa)
MJ_0421Conserved hypothetical protein; Similar to GP:1786625 percent identity: 35.10; identified by sequence similarity; putative. (360 aa)
trm14Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the methylation of the guanosine nucleotide at position 6 (m2G6) in tRNA(Cys). (381 aa)
nep1Conserved hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of pseudouridine at position 914 (Psi914) in 16S rRNA. Is not able to methylate uridine at this position. (205 aa)
flpAFibrillarin (fib); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. (230 aa)
trmG10Conserved hypothetical protein; Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity); Belongs to the methyltransferase superfamily. Trm-G10 family. (351 aa)
trm1N2,N2-dimethylguanosine tRNA methyltransferase (trm1); Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (374 aa)
rsmADimethyladenosine transferase (ksgA); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (275 aa)
mjaVIMModification methylase, type II R/M system; This methylase recognizes the double-stranded sequence CCGG, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the MjaVI endonuclease; Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. (194 aa)
rlmECell division protein FtsJ; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (245 aa)
MJ_1385Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (179 aa)
mjaIIMModification methylase, type II R/M system; This methylase recognizes the double-stranded sequence GGNC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the MjaII endonuclease; Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. (530 aa)
trmJConserved hypothetical protein; Catalyzes the formation of 2'O-methylated cytidine (Cm32) at position 32 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (230 aa)
taw3Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (193 aa)
taw2Met-10+ related protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (249 aa)
trmYConserved hypothetical protein; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family. (205 aa)
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.