STRINGSTRING
cdhE cdhE hpt hpt purP purP cdhC1 cdhC1 cdhA cdhA guaB guaB apgM1 apgM1 pgi pgi pfkC pfkC purS purS purC purC MJ_0667 MJ_0667 hmgA hmgA purO purO MJ_0640 MJ_0640 pgk pgk gap gap guaAB guaAB mvk mvk coaD coaD MJ_0969 MJ_0969 purD purD purB purB coaBC coaBC MJ_0730 MJ_0730 guaAA guaAA MJ_1546 MJ_1546 tpiA tpiA purT purT ndk ndk purL purL rbcL rbcL purQ purQ apgM2 apgM2 mfnA mfnA cdhC2 cdhC2 MJ_0165 MJ_0165 purM purM purF purF dmrX dmrX MJ_0209 MJ_0209 sucC sucC atpB atpB atpA atpA atpF atpF atpC atpC atpE atpE eno eno MJ_0240 MJ_0240 porB porB porA porA porC porC MJ_0395 MJ_0395 MJ_0108 MJ_0108 purA purA atpD atpD purE purE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdhEacetyl-CoA decarbonylase/synthase, subunit gamma (cdhE); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (488 aa)
hptAdenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (183 aa)
purPConserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (361 aa)
cdhC1Carbon monoxide dehydrogenase, subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (748 aa)
cdhAacetyl-CoA decarbonylase/synthase, subunit alpha (cdhA); Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (774 aa)
guaBInosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (496 aa)
apgM1Phosphonopyruvate decarboxylase (bcpC); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (411 aa)
pgiGlucose-6-phosphate isomerase; Catalyzes the isomerization of glucose-6-P to fructose-6-P. (401 aa)
pfkCHypothetical protein; Catalyzes the phosphorylation of fructose 6-phosphate and D- glucose to fructose 1,6-bisphosphate and D-glucose 6-phosphate, respectively, using ADP as the phosphate donor; Belongs to the carbohydrate kinase PfkC family. (462 aa)
purSConserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (83 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase (purC); Similar to GB:J02732 SP:P12046 PID:143367 GB:AL009126 percent identity: 47.66; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family. (242 aa)
MJ_0667Thymidine phosphorylase (deoA); Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. (503 aa)
hmgA3-hydroxy-3-methylglutaryl coenzyme A reductase; Converts HMG-CoA to mevalonate. (405 aa)
purOConserved hypothetical protein; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP; Belongs to the archaeal IMP cyclohydrolase family. (209 aa)
MJ_0640Conserved hypothetical protein; Similar to GP:1001832 percent identity: 33.81; identified by sequence similarity; putative. (324 aa)
pgkPhosphoglycerate kinase (pgk); Similar to GB:M55529 SP:P20971 PID:149808 percent identity: 56.76; identified by sequence similarity; putative; Belongs to the phosphoglycerate kinase family. (417 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; Similar to SP:P10618 PID:149792 percent identity: 60.00; identified by sequence similarity; putative. (343 aa)
guaABGMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. (310 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (312 aa)
coaDConserved hypothetical protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (147 aa)
MJ_0969Conserved hypothetical protein; Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. (270 aa)
purDPhosphoribosylamine--glycine ligase (purD); Similar to GB:J02732 SP:P12039 PID:143374 GB:AL009126 percent identity: 33.73; identified by sequence similarity; putative. (444 aa)
purBAdenylosuccinate lyase (purB); Similar to GB:J02732 SP:P12047 PID:143366 GB:AL009126 percent identity: 42.51; identified by sequence similarity; putative. (462 aa)
coaBCPantothenate metabolism flavoprotein (dfp); Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)
MJ_0730DNA/pantothenate metabolism flavoprotein-like; Similar to GB:L10328 SP:P24285 PID:290489 GB:U00096 PID:1790070 percent identity: 31.20; identified by sequence similarity; putative; To M.jannaschii MJ0208. (186 aa)
guaAAGMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa)
MJ_1546Putative beta-ketoacyl acyl-carrier-protein synthase (fabH); Similar to PID:1197357 percent identity: 64.20; identified by sequence similarity; putative; Belongs to the thiolase-like superfamily. UPF0219 family. (345 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). (219 aa)
purTPhosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
ndkNucleoside diphosphate kinase, (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
purLPhosphoribosylformylglycinamidine synthase II (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (733 aa)
rbcLRibulose bisphosphate carboxylase, large subunit (rbcL); Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (425 aa)
purQPhosphoribosylformylglycinamidine synthase I, (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (230 aa)
apgM2BcpC phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (428 aa)
mfnAGroup II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. (396 aa)
cdhC2acetyl-CoA decarbonylase/synthase, subunit beta (cdhC); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (469 aa)
MJ_0165Conserved hypothetical protein; Similar to GP:1653798 percent identity: 43.43; identified by sequence similarity; putative. (256 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase (purM); Similar to GB:J02732 SP:P12043 PID:143371 GB:AL009126 percent identity: 39.76; identified by sequence similarity; putative. (350 aa)
purFAmidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (471 aa)
dmrX4Fe-4S iron-sulfur protein; Involved in the biosynthesis of tetrahydromethanopterin, a coenzyme used in methanogenesis. Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT). Ferredoxin may serve as an electron donor. (246 aa)
MJ_0209Conserved hypothetical protein; Catalyzes the condensation of (R)-4-phosphopantoate and beta- alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. Belongs to the archaeal phosphopantothenate synthetase family. (266 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (364 aa)
atpBH+-transporting ATP synthase, subunit B (atpB); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (465 aa)
atpAH+-transporting ATP synthase, subunit A (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family. (594 aa)
atpFH+-transporting ATP synthase, subunit F (atpF); Produces ATP from ADP in the presence of a proton gradient across the membrane. (98 aa)
atpCH+-transporting ATP synthase, subunit C (atpC); Produces ATP from ADP in the presence of a proton gradient across the membrane. (399 aa)
atpEH+-transporting ATP synthase, subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane. (206 aa)
enoEnolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
MJ_0240Conserved hypothetical protein; Could catalyze the biosynthesis of cyclic AMP (cAMP) from ATP. (175 aa)
porBPyruvate ferredoxin oxidoreductase, subunit beta (porB); Similar to PID:1197364 percent identity: 58.89; identified by sequence similarity; putative. (298 aa)
porAPyruvate ferredoxin oxidoreductase, subunit alpha (porA); Similar to PID:1197363 percent identity: 57.33; identified by sequence similarity; putative. (389 aa)
porCPyruvate ferredoxin oxidoreductase, subunit gamma (porG); Similar to PID:1197358 percent identity: 63.22; identified by sequence similarity; putative. (178 aa)
MJ_0395Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (158 aa)
MJ_0108Pyruvate kinase; Similar to GB:D13095 SP:Q02499 GB:X57859 PID:285623 percent identity: 38.82; identified by sequence similarity; putative. (447 aa)
purAAdenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (345 aa)
atpDH+-transporting ATP synthase, subunit D (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. (216 aa)
purEPhosphoribosylaminoimidazole carboxylase, (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (157 aa)
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.