node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MJ_0703 | hisA | MJ_0703 | MJ_1532 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA1); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 32.64; identified by sequence similarity; putative. | 0.943 |
MJ_0703 | hisF | MJ_0703 | MJ_0411 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.979 |
MJ_0703 | mfnB | MJ_0703 | MJ_1099 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). | 0.877 |
MJ_0703 | mfnD | MJ_0703 | MJ_0815 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | Conserved hypothetical protein; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro. | 0.625 |
MJ_0703 | mfnE | MJ_0703 | MJ_0458 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | Delta 1-pyrroline-5-carboxylate synthetase; Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1- P) and ATP. In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP. | 0.653 |
MJ_0703 | mfnF | MJ_0703 | MJ_0840 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | Conserved hypothetical protein; Catalyzes the condensation between 5-(aminomethyl)-3- furanmethanol diphosphate (F1-PP) and gamma-glutamyltyramine to produce APMF-Glu. | 0.656 |
hisA | MJ_0703 | MJ_1532 | MJ_0703 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA1); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 32.64; identified by sequence similarity; putative. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | 0.943 |
hisA | hisF | MJ_1532 | MJ_0411 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA1); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 32.64; identified by sequence similarity; putative. | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisF | MJ_0703 | MJ_0411 | MJ_0703 | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | 0.979 |
hisF | hisA | MJ_0411 | MJ_1532 | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA1); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 32.64; identified by sequence similarity; putative. | 0.999 |
mfnA | mfnB | MJ_0050 | MJ_1099 | Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. | Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). | 0.777 |
mfnA | mfnC | MJ_0050 | MJ_0684 | Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. | Aspartate aminotransferase (aspB2); Catalyzes the transamination reaction between 4- (hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) and alanine to produce pyruvate and 5-(aminomethyl)-3-furanmethanol phosphate (F1- P), the precursor for the furan moiety in methanofuran. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.829 |
mfnA | mfnD | MJ_0050 | MJ_0815 | Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. | Conserved hypothetical protein; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro. | 0.986 |
mfnA | mfnE | MJ_0050 | MJ_0458 | Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. | Delta 1-pyrroline-5-carboxylate synthetase; Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1- P) and ATP. In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP. | 0.798 |
mfnA | mfnF | MJ_0050 | MJ_0840 | Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. | Conserved hypothetical protein; Catalyzes the condensation between 5-(aminomethyl)-3- furanmethanol diphosphate (F1-PP) and gamma-glutamyltyramine to produce APMF-Glu. | 0.838 |
mfnB | MJ_0703 | MJ_1099 | MJ_0703 | Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Similar to SP:P05324 PID:150050 PID:44716 percent identity: 30.36; identified by sequence similarity; putative; Belongs to the HisA/HisF family. | 0.877 |
mfnB | mfnA | MJ_1099 | MJ_0050 | Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). | Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. | 0.777 |
mfnB | mfnC | MJ_1099 | MJ_0684 | Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). | Aspartate aminotransferase (aspB2); Catalyzes the transamination reaction between 4- (hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) and alanine to produce pyruvate and 5-(aminomethyl)-3-furanmethanol phosphate (F1- P), the precursor for the furan moiety in methanofuran. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.985 |
mfnB | mfnD | MJ_1099 | MJ_0815 | Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). | Conserved hypothetical protein; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro. | 0.928 |
mfnB | mfnE | MJ_1099 | MJ_0458 | Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). | Delta 1-pyrroline-5-carboxylate synthetase; Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1- P) and ATP. In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP. | 0.954 |