node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCA2087 | hisA | MCA2087 | MCA2803 | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.648 |
MCA2087 | hisB | MCA2087 | MCA2805 | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.621 |
MCA2087 | hisD | MCA2087 | MCA1963 | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.471 |
MCA2087 | hisE | MCA2087 | MCA2800 | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | phosphoribosyl-ATP pyrophosphatase; Identified by similarity to SP:O30723; match to protein family HMM PF01503. | 0.432 |
MCA2087 | hisF | MCA2087 | MCA2802 | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.730 |
MCA2087 | hisH | MCA2087 | MCA2804 | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.689 |
MCA2087 | hisI | MCA2087 | MCA2801 | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.639 |
MCA2087 | hisZ | MCA2087 | MCA1979 | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Conserved hypothetical protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.792 |
hisA | MCA2087 | MCA2803 | MCA2087 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | 0.648 |
hisA | hisB | MCA2803 | MCA2805 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.995 |
hisA | hisD | MCA2803 | MCA1963 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.971 |
hisA | hisE | MCA2803 | MCA2800 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | phosphoribosyl-ATP pyrophosphatase; Identified by similarity to SP:O30723; match to protein family HMM PF01503. | 0.992 |
hisA | hisF | MCA2803 | MCA2802 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | MCA2803 | MCA1964 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.965 |
hisA | hisH | MCA2803 | MCA2804 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | MCA2803 | MCA2801 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | MCA2803 | MCA1979 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Conserved hypothetical protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.887 |
hisB | MCA2087 | MCA2805 | MCA2087 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | 0.621 |
hisB | hisA | MCA2805 | MCA2803 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.995 |
hisB | hisD | MCA2805 | MCA1963 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |