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glmU glmU glmS glmS MCA0215 MCA0215 glk glk MCA0599 MCA0599 MCA0600 MCA0600 pgm pgm MCA0661 MCA0661 gmd gmd fcl fcl MCA1165 MCA1165 pgi pgi glgC glgC glmM glmM murA murA nagZ nagZ MCA2033 MCA2033 galU galU murB murB MCA2449 MCA2449 galE-2 galE-2 ugd ugd MCA2747 MCA2747 MCA2782 MCA2782 MCA2974 MCA2974
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (461 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (610 aa)
MCA0215Aminotransferase, DegT/DnrJ/EryC1/StrS family; Identified by match to protein family HMM PF01041; Belongs to the DegT/DnrJ/EryC1 family. (384 aa)
glkGlucokinase; Identified by similarity to SP:P46880; match to protein family HMM PF00480; match to protein family HMM PF02685; match to protein family HMM TIGR00749; Belongs to the bacterial glucokinase family. (330 aa)
MCA0599Identified by similarity to GP:4545244; match to protein family HMM PF00483. (232 aa)
MCA0600Conserved hypothetical protein; Identified by similarity to GP:4545243. (341 aa)
pgmPhosphoglucomutase; Identified by similarity to SP:P39671; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (544 aa)
MCA0661ROK family protein; Identified by similarity to SP:P75959; match to protein family HMM PF00480. (282 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (372 aa)
fclGDP-L-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (322 aa)
MCA1165Identified by match to protein family HMM PF01370; match to protein family HMM PF07993. (320 aa)
pgiGlucose-6-phosphate isomerase; Identified by similarity to SP:P11537; match to protein family HMM PF00342. (546 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (424 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (447 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa)
nagZbeta-N-acetylhexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (334 aa)
MCA2033Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. (485 aa)
galUUTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to OMNI:NMB0638; match to protein family HMM PF00483; match to protein family HMM TIGR01099. (292 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa)
MCA2449Capsular polysaccharide biosynthesis protein I; Identified by similarity to SP:P39858; match to protein family HMM PF01370; match to protein family HMM PF07993. (336 aa)
galE-2UDP-glucose 4-epimerase; Identified by similarity to SP:Q59083; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (341 aa)
ugdUDP-glucose 6-dehydrogenase; Identified by similarity to SP:O54068; match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721. (442 aa)
MCA2747Cellulose-binding domain protein; Identified by match to protein family HMM PF00553. (671 aa)
MCA2782Identified by similarity to GP:150994; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (463 aa)
MCA2974PKD domain protein. (833 aa)
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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