node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCA0105 | mrcA | MCA0105 | MCA0324 | D-alanyl-D-alanine carboxypeptidase; Identified by similarity to SP:P08506; match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; Belongs to the peptidase S11 family. | Penicillin-binding protein 1A; Identified by similarity to SP:P02918; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074. | 0.911 |
MCA0105 | mrdA | MCA0105 | MCA0103 | D-alanyl-D-alanine carboxypeptidase; Identified by similarity to SP:P08506; match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; Belongs to the peptidase S11 family. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.905 |
MCA1576 | MCA1672 | MCA1576 | MCA1672 | Putative penicillin-binding protein; Identified by similarity to SP:P76577; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF06832; match to protein family HMM TIGR02073. | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.922 |
MCA1576 | mrcA | MCA1576 | MCA0324 | Putative penicillin-binding protein; Identified by similarity to SP:P76577; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF06832; match to protein family HMM TIGR02073. | Penicillin-binding protein 1A; Identified by similarity to SP:P02918; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074. | 0.927 |
MCA1576 | mrdA | MCA1576 | MCA0103 | Putative penicillin-binding protein; Identified by similarity to SP:P76577; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF06832; match to protein family HMM TIGR02073. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.517 |
MCA1576 | murF | MCA1576 | MCA1294 | Putative penicillin-binding protein; Identified by similarity to SP:P76577; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF06832; match to protein family HMM TIGR02073. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.429 |
MCA1672 | MCA1576 | MCA1672 | MCA1576 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Putative penicillin-binding protein; Identified by similarity to SP:P76577; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF06832; match to protein family HMM TIGR02073. | 0.922 |
MCA1672 | ddL | MCA1672 | MCA2426 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | D-alanine--D-alanine ligase; Cell wall formation. | 0.534 |
MCA1672 | ftsI | MCA1672 | MCA2434 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | 0.822 |
MCA1672 | mrcA | MCA1672 | MCA0324 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Penicillin-binding protein 1A; Identified by similarity to SP:P02918; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074. | 0.952 |
MCA1672 | mrdA | MCA1672 | MCA0103 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.751 |
MCA1672 | murA | MCA1672 | MCA1965 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.537 |
MCA1672 | murC | MCA1672 | MCA2428 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.588 |
MCA1672 | murD | MCA1672 | MCA2431 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.526 |
MCA1672 | murE | MCA1672 | MCA2433 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.401 |
MCA1672 | murF | MCA1672 | MCA1294 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.561 |
MCA1672 | murG | MCA1672 | MCA2429 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.618 |
MCA2985 | mraY | MCA2985 | MCA2432 | PAP2 superfamily protein; Identified by match to protein family HMM PF01569. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.902 |
MCA2985 | uppP | MCA2985 | MCA0666 | PAP2 superfamily protein; Identified by match to protein family HMM PF01569. | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.916 |
MCA2985 | uppS | MCA2985 | MCA0571 | PAP2 superfamily protein; Identified by match to protein family HMM PF01569. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.911 |