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pmoC3 pmoC3 MCA0299 MCA0299 MCA0508 MCA0508 mdh mdh gpmA gpmA MCA0770 MCA0770 mxaF mxaF MCA0780 MCA0780 MCA0781 MCA0781 mxaI mxaI MCA0785 MCA0785 MCA0786 MCA0786 MCA0787 MCA0787 MCA0788 MCA0788 MCA0789 MCA0789 mmoX mmoX mmoY mmoY mmoB mmoB mmoZ mmoZ mmoD mmoD mmoC mmoC MCA1208 MCA1208 MCA1209 MCA1209 MCA1210 MCA1210 MCA1243 MCA1243 pfp pfp serB serB MCA1389 MCA1389 MCA1391 MCA1391 MCA1392 MCA1392 MCA1393 MCA1393 sgaA sgaA serC serC MCA1528 MCA1528 MCA1529 MCA1529 MCA1530 MCA1530 ackA ackA glyA glyA MCA1739 MCA1739 sucC-2 sucC-2 sucD-2 sucD-2 pmoB pmoB pmoA pmoA pmoC1 pmoC1 eno-1 eno-1 acs acs MCA2319 MCA2319 eno-2 eno-2 MCA2576 MCA2576 MCA2577 MCA2577 MCA2738 MCA2738 MCA2778 MCA2778 MCA2857 MCA2857 ffsA ffsA MCA2859 MCA2859 MCA2860 MCA2860 mch mch MCA2866 MCA2866 MCA2868 MCA2868 MCA2869 MCA2869 MCA2871 MCA2871 MCA3018 MCA3018 MCA3019 MCA3019 fbaA-1 fbaA-1 MCA3043 MCA3043 MCA3044 MCA3044
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pmoC3Methane monooxygenase, C subunit; Identified by similarity to GP:14456716; match to protein family HMM PF04896. (253 aa)
MCA0299Putative methanol dehydrogenase protein, large subunit; Identified by similarity to SP:P15279; match to protein family HMM PF01011. (619 aa)
MCA0508Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. (286 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
gpmAPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (546 aa)
MCA0770Pyridine nucleotide-disulphide oxidoreductase family protein; Identified by similarity to GP:10120476; match to protein family HMM PF00037; match to protein family HMM PF00070; match to protein family HMM PF07992. (546 aa)
mxaFMethanol dehydrogenase protein, large subunit; Identified by similarity to SP:P16027; match to protein family HMM PF01011. (601 aa)
MCA0780MxaJ protein; Identified by similarity to GP:7258335. (190 aa)
MCA0781Cytochrome c family protein; Identified by similarity to SP:P14774; match to protein family HMM PF00034. (159 aa)
mxaIMethanol dehydrogenase, small subunit; Catalyzes the oxidation of primary alcohols including methanol. (94 aa)
MCA0785MxaA protein; Identified by similarity to GP:773180. (290 aa)
MCA0786MxaC protein; Identified by similarity to GP:1164996. (327 aa)
MCA0787MxaK protein; Identified by similarity to GP:2828246. (172 aa)
MCA0788MxaL protein; Identified by similarity to GP:773183. (323 aa)
MCA0789MxaD protein; Identified by similarity to GP:773184. (174 aa)
mmoXMethane monooxygenase, A subunit, alpha chain; Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds; Belongs to the TmoA/XamoA family. (527 aa)
mmoYMethane monooxygenase, A subunit, beta chain; Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. (389 aa)
mmoBMethane monooxygenase, B subunit; The B protein acts as a regulator of electron flow through the soluble mmo complex, switching the enzyme from an oxidase to a hydroxylase in the presence of the substrate; Belongs to the TmoD/XamoD family. (141 aa)
mmoZMethane monooxygenase, A subunit, gamma chain; Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. (170 aa)
mmoDMethane monooxygenase, D subunit. (103 aa)
mmoCMethane monooxygenase, C subunit; Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. The component C is the iron-sulfur flavoprotein of sMMO. (348 aa)
MCA1208Putative formate dehydrogenase, gamma subunit; Identified by similarity to SP:P32174; match to protein family HMM TIGR01583. (211 aa)
MCA1209Formate dehydrogenase, iron-sulfur subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (290 aa)
MCA1210Formate dehydrogenase, alpha subunit; Identified by similarity to SP:P32176; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553. (1066 aa)
MCA1243Conserved hypothetical protein; Identified by similarity to SP:Q58499. (236 aa)
pfpPutative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...] (420 aa)
serBPhosphoserine phosphatase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. (280 aa)
MCA1389Formate dehydrogenase, delta subunit; Identified by similarity to GP:3724147. (77 aa)
MCA1391Formate dehydrogenase, alpha subunit; Identified by similarity to GP:17743211; match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01591. (947 aa)
MCA1392Formate dehydrogenase, beta subunit; Identified by similarity to GP:3724144; match to protein family HMM PF01512. (516 aa)
MCA1393Formate dehydrogenase, gamma subunit; Identified by similarity to GP:3724143; match to protein family HMM PF01257. (159 aa)
sgaASerine--glyoxylate aminotransferase; Identified by similarity to SP:P55819; match to protein family HMM PF00266. (395 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa)
MCA1528Putative MxaC protein; Identified by similarity to GP:1164996. (325 aa)
MCA1529Putative MxaK protein; Identified by similarity to GP:2828246. (184 aa)
MCA1530Putative MxaL protein; Identified by similarity to GP:773183. (308 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
MCA1739Putative citrate lyase, beta subunit; Identified by similarity to SP:P77770; Belongs to the HpcH/HpaI aldolase family. (320 aa)
sucC-2succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucD-2succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
pmoBMethane monooxygenase, B subunit; Methane monooxygenase is responsible for the initial oxygenation of methane to methanol in methanotrophs. At least in vitro, specific quinols can replace NADH as reductants. (414 aa)
pmoAMethane monooxygenase, A subunit; Non-catalytic subunit of the methane monooxygenase that is responsible for the initial oxygenation of methane to methanol in methanotrophs. At least in vitro, specific quinols can replace NADH as reductants. (247 aa)
pmoC1Methane monooxygenase, C subunit; Identified by similarity to GP:1894818; match to protein family HMM PF04896. (260 aa)
eno-1Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (421 aa)
acsacetyl-CoA synthase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (662 aa)
MCA2319Putative formylmethanofurane dehydrogenase, subunit; Identified by similarity to GP:13559971; match to protein family HMM PF07969. (572 aa)
eno-2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (427 aa)
MCA2576Formate dehydrogenase, alpha subunit; Identified by similarity to SP:P07658; match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01591. (925 aa)
MCA2577Putative dehydrogenase subunit; Identified by similarity to GP:4007678; match to protein family HMM PF01257; match to protein family HMM PF01512. (561 aa)
MCA2738Putative hexulose-6-phosphate synthase/SIS domain protein; Identified by similarity to GP:6899861; match to protein family HMM PF00215; match to protein family HMM PF01380. (389 aa)
MCA2778Formaldehyde-activating enzyme domain protein; Identified by similarity to GP:11193064. (119 aa)
MCA2857Putative formylmethanofurane dehydrogenase subunit; Identified by similarity to SP:Q59579; match to protein family HMM PF01493. (270 aa)
ffsAFormylmethanofurane tetrahydromethanopterin formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (298 aa)
MCA2859Putative formylmethanofurane dehydrogenase, A subunit; Identified by similarity to GP:1890210; match to protein family HMM PF07969. (555 aa)
MCA2860Formylmethanofuran dehydrogenase; Identified by similarity to GP:1881465. (423 aa)
mchPutative n5,n10-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (331 aa)
MCA2866Formaldehyde-activating enzyme; Identified by similarity to GP:11193064. (170 aa)
MCA2868Conserved hypothetical protein; Identified by similarity to GP:2621925; match to protein family HMM PF02655. (330 aa)
MCA2869Putative S-layer protein. (353 aa)
MCA2871Amino acid kinase family protein; Identified by match to protein family HMM PF00696. (197 aa)
MCA3018Putative methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. (301 aa)
MCA3019Putative methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. (293 aa)
fbaA-1Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
MCA3043Hexulose-6-phosphate synthase; Identified by similarity to GP:6899861; match to protein family HMM PF00215. (215 aa)
MCA3044SIS domain protein; Identified by match to protein family HMM PF01380. (177 aa)
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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