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| | pgl-1 | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (235 aa) |
| | zwf-1 | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (609 aa) |
| | eda | 4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase; Identified by similarity to SP:P10177; match to protein family HMM PF01081; match to protein family HMM TIGR01182. (221 aa) |
| | rpiB | Ribose 5-phosphate isomerase B; Identified by similarity to SP:P37351; match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (142 aa) |
| | hemL | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P23893; match to protein family HMM PF00202; match to protein family HMM TIGR00713. (426 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Identified by similarity to SP:P00394; match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. (289 aa) |
| | MCA0165 | Nickel-iron hydrogenase, large subunit; Identified by similarity to SP:P18636; match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa) |
| | MCA0166 | Nickel-iron hydrogenase, small subunit; Identified by similarity to SP:P21950; match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409. (362 aa) |
| | MCA0182 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01565; match to protein family HMM PF02913. (467 aa) |
| | MCA0225 | Rieske 2Fe-2S family protein; Identified by similarity to GP:1754625; match to protein family HMM PF00355. (108 aa) |
| | nifH | Nitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (293 aa) |
| | nifD | Nitrogenase molybdenum-iron protein alpha chain; Identified by similarity to SP:P06120; match to protein family HMM PF00148; match to protein family HMM TIGR01282; match to protein family HMM TIGR01862. (486 aa) |
| | nifK | Nitrogenase molybdenum-iron protein beta chain; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family. (519 aa) |
| | MCA0263 | Identified by similarity to OMNI:NTL01BM1881; match to protein family HMM PF01557. (225 aa) |
| | pmoC3 | Methane monooxygenase, C subunit; Identified by similarity to GP:14456716; match to protein family HMM PF04896. (253 aa) |
| | MCA0297 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SMB00167. (270 aa) |
| | MCA0299 | Putative methanol dehydrogenase protein, large subunit; Identified by similarity to SP:P15279; match to protein family HMM PF01011. (619 aa) |
| | MCA0351 | Carboxymuconolactone decarboxylase domain protein; Identified by match to protein family HMM PF02627. (108 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (218 aa) |
| | MCA0390 | Aspartate kinase, monofunctional class; Identified by similarity to SP:P26512; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00656; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (409 aa) |
| | MCA0431 | Flavodoxin domain protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (883 aa) |
| | MCA0508 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. (286 aa) |
| | glk | Glucokinase; Identified by similarity to SP:P46880; match to protein family HMM PF00480; match to protein family HMM PF02685; match to protein family HMM TIGR00749; Belongs to the bacterial glucokinase family. (330 aa) |
| | MCA0586 | Rieske 2Fe-2S family protein; Identified by similarity to GP:1754625; match to protein family HMM PF00355. (104 aa) |
| | nasA | Nitrate reductase; Identified by similarity to SP:Q06457; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04324; match to protein family HMM PF04879; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (879 aa) |
| | nirD | Nitrite reductase [NAD(P)H], small subunit; Identified by similarity to SP:P42436; match to protein family HMM PF00355; match to protein family HMM TIGR02378. (118 aa) |
| | nirB | Nitrite reductase [NAD(P)H], large subunit; Identified by similarity to SP:P42435; match to protein family HMM PF00070; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM PF04324; match to protein family HMM PF07992; match to protein family HMM TIGR02374; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (820 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (380 aa) |
| | hom | Homoserine dehydrogenase; Identified by similarity to SP:P29365; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. (436 aa) |
| | pgm | Phosphoglucomutase; Identified by similarity to SP:P39671; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (544 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa) |
| | MCA0639 | NADH-dependent flavin oxidoreductase, Oye family; Identified by match to protein family HMM PF00724. (372 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa) |
| | acyP | Acylphosphatase; Identified by similarity to SP:O29440; match to protein family HMM PF00708. (92 aa) |
| | gpmA | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (546 aa) |
| | MCA0769 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. (1188 aa) |
| | MCA0770 | Pyridine nucleotide-disulphide oxidoreductase family protein; Identified by similarity to GP:10120476; match to protein family HMM PF00037; match to protein family HMM PF00070; match to protein family HMM PF07992. (546 aa) |
| | MCA0775 | Alcohol dehydrogenase, zinc-containing; Identified by similarity to OMNI:MT1911; match to protein family HMM PF00107. (342 aa) |
| | mxaF | Methanol dehydrogenase protein, large subunit; Identified by similarity to SP:P16027; match to protein family HMM PF01011. (601 aa) |
| | MCA0780 | MxaJ protein; Identified by similarity to GP:7258335. (190 aa) |
| | MCA0781 | Cytochrome c family protein; Identified by similarity to SP:P14774; match to protein family HMM PF00034. (159 aa) |
| | mxaI | Methanol dehydrogenase, small subunit; Catalyzes the oxidation of primary alcohols including methanol. (94 aa) |
| | MCA0785 | MxaA protein; Identified by similarity to GP:773180. (290 aa) |
| | MCA0786 | MxaC protein; Identified by similarity to GP:1164996. (327 aa) |
| | MCA0787 | MxaK protein; Identified by similarity to GP:2828246. (172 aa) |
| | MCA0788 | MxaL protein; Identified by similarity to GP:773183. (323 aa) |
| | MCA0789 | MxaD protein; Identified by similarity to GP:773184. (174 aa) |
| | gltA | Citrate synthase; Identified by similarity to SP:Q10530; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family. (429 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa) |
| | MCA0950 | Identified by match to protein family HMM PF01425; Belongs to the amidase family. (341 aa) |
| | MCA0956 | Hydroxylamine oxydoreductase; Identified by similarity to SP:Q50925. (559 aa) |
| | sucC-1 | succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | sucD-1 | succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | MCA0987 | Rieske 2Fe-2S family protein; Identified by similarity to GP:17942398; match to protein family HMM PF00355. (106 aa) |
| | cysK | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | gluD | Glutamate dehydrogenase, NAD-specific; Identified by similarity to SP:P80053; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (374 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (420 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa) |
| | MCA1132 | Conserved hypothetical protein; Identified by similarity to GP:17131502. (498 aa) |
| | mmoX | Methane monooxygenase, A subunit, alpha chain; Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds; Belongs to the TmoA/XamoA family. (527 aa) |
| | mmoY | Methane monooxygenase, A subunit, beta chain; Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. (389 aa) |
| | mmoB | Methane monooxygenase, B subunit; The B protein acts as a regulator of electron flow through the soluble mmo complex, switching the enzyme from an oxidase to a hydroxylase in the presence of the substrate; Belongs to the TmoD/XamoD family. (141 aa) |
| | mmoZ | Methane monooxygenase, A subunit, gamma chain; Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. (170 aa) |
| | mmoD | Methane monooxygenase, D subunit. (103 aa) |
| | mmoC | Methane monooxygenase, C subunit; Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. The component C is the iron-sulfur flavoprotein of sMMO. (348 aa) |
| | MCA1208 | Putative formate dehydrogenase, gamma subunit; Identified by similarity to SP:P32174; match to protein family HMM TIGR01583. (211 aa) |
| | MCA1209 | Formate dehydrogenase, iron-sulfur subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (290 aa) |
| | MCA1210 | Formate dehydrogenase, alpha subunit; Identified by similarity to SP:P32176; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553. (1066 aa) |
| | gltX-2 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (468 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (197 aa) |
| | pgi | Glucose-6-phosphate isomerase; Identified by similarity to SP:P11537; match to protein family HMM PF00342. (546 aa) |
| | pfp | Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...] (420 aa) |
| | serB | Phosphoserine phosphatase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. (280 aa) |
| | MCA1389 | Formate dehydrogenase, delta subunit; Identified by similarity to GP:3724147. (77 aa) |
| | MCA1391 | Formate dehydrogenase, alpha subunit; Identified by similarity to GP:17743211; match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01591. (947 aa) |
| | MCA1392 | Formate dehydrogenase, beta subunit; Identified by similarity to GP:3724144; match to protein family HMM PF01512. (516 aa) |
| | MCA1393 | Formate dehydrogenase, gamma subunit; Identified by similarity to GP:3724143; match to protein family HMM PF01257. (159 aa) |
| | sgaA | Serine--glyoxylate aminotransferase; Identified by similarity to SP:P55819; match to protein family HMM PF00266. (395 aa) |
| | MCA1407 | D-isomer specific 2-hydroxyacid dehydrogenase family protein; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
| | MCA1436 | Putative serine acetyltransferase CysE; Identified by similarity to SP:P71405; match to protein family HMM PF00132. (170 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Identified by similarity to SP:P03948; match to protein family HMM PF00132; match to protein family HMM TIGR00965; Belongs to the transferase hexapeptide repeat family. (271 aa) |
| | MCA1491 | Aminotransferase, class I; Identified by similarity to OMNI:NTL03PA03659; match to protein family HMM PF00155. (398 aa) |
| | MCA1499 | Glycolate oxidase, iron-sulfur subunit; Identified by similarity to SP:P52074; match to protein family HMM PF00037; match to protein family HMM PF02754. (402 aa) |
| | glcE | Glycolate oxidase, GlcE subunit; Identified by similarity to SP:P52073; match to protein family HMM PF01565. (353 aa) |
| | glcD | Glycolate oxidase, GlcD subunit; Identified by similarity to SP:P52075; match to protein family HMM PF01565; match to protein family HMM PF02913. (484 aa) |
| | MCA1504 | Putative sulfite oxidase SoxC; Identified by similarity to GP:7381242; match to protein family HMM PF00174; match to protein family HMM PF02012; match to protein family HMM PF03404; match to protein family HMM TIGR01409. (419 aa) |
| | MCA1528 | Putative MxaC protein; Identified by similarity to GP:1164996. (325 aa) |
| | MCA1529 | Putative MxaK protein; Identified by similarity to GP:2828246. (184 aa) |
| | MCA1530 | Putative MxaL protein; Identified by similarity to GP:773183. (308 aa) |
| | sdhB | Succinate dehydrogenase, iron-sulfur protein; Identified by similarity to SP:Q59662; match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (260 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (469 aa) |
| | MCA1548 | Putative succinate dehydrogenase, cytochrome b556 subunit; Identified by similarity to SP:P10446; match to protein family HMM PF01127. (138 aa) |
| | MCA1549 | Putative succinate dehydrogenase, hydrophobic membrane anchor protein; Identified by similarity to SP:P10445; match to protein family HMM PF01127. (126 aa) |
| | sdhA | Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P31038; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (595 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (377 aa) |
| | sseA | Mercaptopyruvate sulfurtransferase; Identified by similarity to GP:6009981; match to protein family HMM PF00581. (316 aa) |
| | MCA1575 | Alcohol dehydrogenase, zinc-containing; Identified by similarity to GP:17739984; match to protein family HMM PF00107. (355 aa) |
| | MCA1587 | Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase; Identified by similarity to SP:Q9AEM9; match to protein family HMM PF03894. (811 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | glnA | Glutamine synthetase, type I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa) |
| | MCA1684 | Conserved domain protein; Identified by similarity to GP:11830835; match to protein family HMM PF05088. (1122 aa) |
| | MCA1716 | In some systems, close homologs of ribose-phosphate pyrophosphokinase lacking enzymatic activity exist and perform regulatory functions; identified by match to protein family HMM PF00156; match to protein family HMM TIGR01251. (289 aa) |
| | MCA1739 | Putative citrate lyase, beta subunit; Identified by similarity to SP:P77770; Belongs to the HpcH/HpaI aldolase family. (320 aa) |
| | sucC-2 | succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | sucD-2 | succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | MCA1748 | Iron-sulfur cluster binding protein; Identified by match to protein family HMM PF00037; match to protein family HMM PF02754. (399 aa) |
| | gabD | Succinate-semialdehyde dehydrogenase (NADP+); Identified by similarity to SP:P25526; match to protein family HMM PF00171; match to protein family HMM TIGR01780; Belongs to the aldehyde dehydrogenase family. (491 aa) |
| | pmoB | Methane monooxygenase, B subunit; Methane monooxygenase is responsible for the initial oxygenation of methane to methanol in methanotrophs. At least in vitro, specific quinols can replace NADH as reductants. (414 aa) |
| | pmoA | Methane monooxygenase, A subunit; Non-catalytic subunit of the methane monooxygenase that is responsible for the initial oxygenation of methane to methanol in methanotrophs. At least in vitro, specific quinols can replace NADH as reductants. (247 aa) |
| | pmoC1 | Methane monooxygenase, C subunit; Identified by similarity to GP:1894818; match to protein family HMM PF04896. (260 aa) |
| | MCA1799 | Cytochrome c family protein; Identified by similarity to SP:Q06529. (99 aa) |
| | MCA1800 | Putative oxidoreductase; Identified by similarity to GP:19879585; match to protein family HMM PF07992. (408 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (321 aa) |
| | cysE-1 | Serine acetyltransferase; Identified by similarity to SP:P74089; match to protein family HMM PF00132; match to protein family HMM TIGR01172. (249 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (269 aa) |
| | eno-1 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (421 aa) |
| | gnd | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (505 aa) |
| | sucA | 2-oxoglutarate dehydrogenase, E1 component; Identified by similarity to SP:P07015; match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM TIGR00239. (937 aa) |
| | sucB | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (381 aa) |
| | soxY | Sulfur compound-chelating protein SoxY; Identified by similarity to GP:19879576. (148 aa) |
| | soxZ | Sulfur compound-chelating protein SoxZ; Identified by similarity to GP:19879577. (100 aa) |
| | pgk | Phosphoglycerate kinase; Identified by similarity to SP:P11665; match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (391 aa) |
| | gltB | Glutamate synthase, large subunit; Identified by similarity to SP:P39812; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898. (1542 aa) |
| | gltD | Glutamate synthase, NADH/NADPH small subunit; Identified by similarity to GP:17429987; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01317. (479 aa) |
| | acs | acetyl-CoA synthase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (662 aa) |
| | MCA2059 | Nitrite/sulfite reductase protein; Identified by match to protein family HMM PF01077; match to protein family HMM PF03460. (548 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | argD | Acetylornithine aminotransferase; Identified by similarity to SP:O27392; match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (391 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (474 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (203 aa) |
| | fhs | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P21164; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. (557 aa) |
| | MCA2319 | Putative formylmethanofurane dehydrogenase, subunit; Identified by similarity to GP:13559971; match to protein family HMM PF07969. (572 aa) |
| | MCA2400 | Putative nitric-oxide reductase, B subunit; Identified by similarity to SP:P98008. (481 aa) |
| | MCA2401 | Conserved domain protein; Identified by similarity to OMNI:NTL01ATA0505. (200 aa) |
| | cysH | Phosophoadenylyl-sulfate reductase; Reduction of activated sulfate into sulfite. (240 aa) |
| | oadB | Oxaloacetate decarboxylase, beta subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (375 aa) |
| | MCA2485 | Aconitate hydratase; Identified by similarity to SP:P36683; match to protein family HMM PF00330; match to protein family HMM PF06434; match to protein family HMM TIGR00117; Belongs to the aconitase/IPM isomerase family. (858 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (324 aa) |
| | eno-2 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (427 aa) |
| | MCA2576 | Formate dehydrogenase, alpha subunit; Identified by similarity to SP:P07658; match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01591. (925 aa) |
| | MCA2577 | Putative dehydrogenase subunit; Identified by similarity to GP:4007678; match to protein family HMM PF01257; match to protein family HMM PF01512. (561 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Identified by similarity to SP:P32661; match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (230 aa) |
| | pyk | Pyruvate kinase; Identified by similarity to SP:P21599; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (488 aa) |
| | gap | Glyceraldehyde 3-phosphate dehydrogenase; Identified by similarity to SP:P50321; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | cysE-2 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. (261 aa) |
| | cysN | Putative nodQ bifunctional enzyme; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (549 aa) |
| | cysD | Sulfate adenylyltransferase, subunit 2; Identified by similarity to SP:O50273; match to protein family HMM PF01507; match to protein family HMM TIGR02039. (302 aa) |
| | MCA2738 | Putative hexulose-6-phosphate synthase/SIS domain protein; Identified by similarity to GP:6899861; match to protein family HMM PF00215; match to protein family HMM PF01380. (389 aa) |
| | cbbL | Ribulose bisphosphate carboxylase, large subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. (473 aa) |
| | cbbS | Ribulose bisphosphate carboxylase, small subunit; Identified by similarity to GP:17646562; match to protein family HMM PF00101. (118 aa) |
| | MCA2776 | Pyridine nucleotide-disulphide oxidoreductase family protein; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992. (380 aa) |
| | MCA2778 | Formaldehyde-activating enzyme domain protein; Identified by similarity to GP:11193064. (119 aa) |
| | MCA2782 | Identified by similarity to GP:150994; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (463 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Identified by similarity to SP:Q59643; match to protein family HMM PF00490; Belongs to the ALAD family. (334 aa) |
| | MCA2806 | Pyridoxal-dependent decarboxylase domain protein; Identified by similarity to OMNI:NTL01BH0567; match to protein family HMM PF00282. (560 aa) |
| | MCA2857 | Putative formylmethanofurane dehydrogenase subunit; Identified by similarity to SP:Q59579; match to protein family HMM PF01493. (270 aa) |
| | ffsA | Formylmethanofurane tetrahydromethanopterin formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (298 aa) |
| | MCA2859 | Putative formylmethanofurane dehydrogenase, A subunit; Identified by similarity to GP:1890210; match to protein family HMM PF07969. (555 aa) |
| | MCA2860 | Formylmethanofuran dehydrogenase; Identified by similarity to GP:1881465. (423 aa) |
| | mch | Putative n5,n10-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (331 aa) |
| | MCA2866 | Formaldehyde-activating enzyme; Identified by similarity to GP:11193064. (170 aa) |
| | pgl-2 | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (235 aa) |
| | zwf-2 | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (494 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (272 aa) |
| | aceE | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa) |
| | aceF | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (436 aa) |
| | lpdA | Pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase; Identified by similarity to SP:P00391; match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. (473 aa) |
| | MCA3018 | Putative methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. (301 aa) |
| | MCA3019 | Putative methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. (293 aa) |
| | ppdK | Pyruvate, phosphate dikinase; Identified by similarity to GP:2285879; match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family. (906 aa) |
| | tkt-1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (670 aa) |
| | fbaA-1 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | MCA3043 | Hexulose-6-phosphate synthase; Identified by similarity to GP:6899861; match to protein family HMM PF00215. (215 aa) |
| | MCA3044 | SIS domain protein; Identified by match to protein family HMM PF01380. (177 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (329 aa) |
| | tkt-2 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (670 aa) |
| | cbbP | Phosphoribulokinase; Identified by similarity to SP:P23015; match to protein family HMM PF00485. (292 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (351 aa) |
| | hemDX | uroporphyrinogen-III synthase/uroporphyrin-III C-methyltransferase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (672 aa) |
| | MCA3071 | Putative isocitrate dehydrogenase, NAD-dependent; Identified by similarity to GP:15023878; match to protein family HMM PF00180. (340 aa) |
