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| | pyrF | Orotidine-5'-phosphate decarboxylase (OMP decarboxylase); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (248 aa) |
| | dnaN | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (366 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to [...] (457 aa) |
| | atpC | ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | atpD | ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpA | ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | atpH | ATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa) |
| | atpF | ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa) |
| | atpE | ATP synthase C chain (Lipid-binding protein) (Dicyclohexylcarbodiimide-binding protein); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa) |
| | atpB | ATP synthase A chain (Protein 6); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (274 aa) |
| | acs | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (651 aa) |
| | plu0077 | Unnamed protein product; Similar to transcription initiation factor sigma homolog; Belongs to the sigma-70 factor family. ECF subfamily. (196 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (366 aa) |
| | aroK | Shikimate kinase I (SKI); Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | plu0104 | Unnamed protein product; Similar to putative secreted protein. (164 aa) |
| | plu0116 | ATP-grasp domain-containing protein; Unnamed protein product; Some similarities with putative carboxylase. (397 aa) |
| | hemN | Oxygen-independent coproporphyrinogen III oxidase (coproporphyrinogenase) (coprogen oxidase); Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa) |
| | plu0243 | N-acetyltransferase domain-containing protein; Unnamed protein product; Highly similar to putative acetyltransferase YiiD of Escherichia coli. (305 aa) |
| | spoT | GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (705 aa) |
| | rpoZ | DNA-directed RNA polymerase omega chain (transcriptase omega chain) (RNA polymerase omega subunit); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (91 aa) |
| | gmk | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (929 aa) |
| | nusG | Transcription antitermination factor; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination; Belo [...] (181 aa) |
| | rpoB | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1342 aa) |
| | rpoC | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1406 aa) |
| | plu0449 | CTP_transf_like domain-containing protein; Unnamed protein product; Some similarities with unknown protein. (208 aa) |
| | thiH | Thiamin biosynthesis, thiazole moiety. (363 aa) |
| | thiG | Thiamin biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa) |
| | thiS | ThiS protein. (66 aa) |
| | thiF | 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate synthesis protein. (249 aa) |
| | thiE | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (216 aa) |
| | thiC | Thiamin biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (645 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | purD | Phosphoribosylglycinamide synthetase; Belongs to the GARS family. (427 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase (bifunctional enzyme). (529 aa) |
| | queH | Epoxyqueuosine reductase QueH; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (222 aa) |
| | plu0544 | ZnF_CHCC domain-containing protein; Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1104 aa) |
| | nadR | Transcriptional regulator NadR. (418 aa) |
| | ribF | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (314 aa) |
| | carA | Carbamoyl-phosphate synthase (glutamine-hydrolyzing); Belongs to the CarA family. (387 aa) |
| | carB | Carbamoylphosphate synthetase large subunit; Belongs to the CarB family. (1074 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa) |
| | apaG | ApaG protein. (125 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase); Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (339 aa) |
| | thyA | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa) |
| | pyrH | Uridine 5'-monophosphate (UMP) kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa) |
| | dnaE | DNA polymerase III alpha subunit. (1160 aa) |
| | accA | acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | gmhB1 | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. (188 aa) |
| | queE | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | plu0702 | 6-carboxy-5,6,7,8-tetrahydropterin synthase; Unnamed protein product; Highly similar to putative 6-pyruvoyl tetrahydrobiopterin synthase (PTPS). (120 aa) |
| | cysG | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (470 aa) |
| | rpoS | RNA polymerase sigma factor (sigma-38); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (332 aa) |
| | plu0741 | Unnamed protein product; Similar to probable sigma-70 factor, ECF subfamily. (169 aa) |
| | purA1 | Adenylosuccinate synthetase 1; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (419 aa) |
| | plu0841 | Isochorismatase domain-containing protein; Unnamed protein product; Similar to amidase. (179 aa) |
| | plu0860 | Unnamed protein product; Highly similar to hypoxanthine phosphoribosyltransferase of Escherichia coli; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | plu0864 | Unnamed protein product; Highly similar to hypoxanthine phosphoribosyltransferase of Escherichia coli; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa) |
| | folK | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (171 aa) |
| | plu0884 | Pyosin/cloacin_T_dom domain-containing protein; Unnamed protein product; Some similarities with killer protein of pyocin S3 and highly similar to Photorhabdus luminescens unknown protein. (557 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase. (427 aa) |
| | relA | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (743 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | plu0936 | Thymidylate_kin domain-containing protein; Unnamed protein product; Some similarities with thymidylate kinase. (178 aa) |
| | dnaQ | DNA polymerase III epsilon chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (248 aa) |
| | epd | D-erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (339 aa) |
| | ngrA | 4'-phosphopantetheinyl tranferase; Belongs to the P-Pant transferase superfamily. (247 aa) |
| | plu1031 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (459 aa) |
| | plu1111 | Unnamed protein product; Similar to reverse transcriptase/maturase. (469 aa) |
| | plu1126 | ZnF_CHCC domain-containing protein; Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1104 aa) |
| | plu1136 | Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1104 aa) |
| | plu1144 | Unnamed protein product. (488 aa) |
| | plu1145 | Unnamed protein product. (603 aa) |
| | plu1176 | Heme chaperone HemW; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (376 aa) |
| | plu1183 | UPF0301 protein plu1183; Unnamed protein product; Similar to unknown protein YqgE of Escherichia coli; Belongs to the UPF0301 (AlgH) family. (187 aa) |
| | plu1228 | Unnamed protein product; Similar to unknown protein. Putative transmembrane protein. (350 aa) |
| | plu1235 | Unnamed protein product; Similar to sigma-70 factor, ECF subfamily. (166 aa) |
| | dinP | DNA polymerase IV (DNA-damage-inducible protein P); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa) |
| | gpt | Xanthine-guanine phosphoribosyltransferase (XGPRT); Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (153 aa) |
| | aroL | Shikimate kinase II (SKII); Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa) |
| | plu1248 | CinA domain-containing protein; Unnamed protein product; Similar to unknown protein YgaD of Escherichia coli; Belongs to the CinA family. (180 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (364 aa) |
| | tyrA | T-protein [includes: chorismate mutase (CM); prephenate dehydrogenase (PDH)]. (373 aa) |
| | pheA | P-protein [includes: chorismate mutase (CM); prephenate dehydratase (PDT)]. (385 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase 2 beta chain (ribonucleotide reductase 2) (R2f protein); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | nadD | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (225 aa) |
| | holA | DNA-directed DNA polymerase III delta chain. (346 aa) |
| | corC | Magnesium and cobalt efflux protein CorC. (293 aa) |
| | plu1369 | Lactamase_B domain-containing protein; Unnamed protein product; Similar to metal-dependent hydrolases of the beta-lactamase superfamily II. (266 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | hemF | Oxygen-dependent coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (302 aa) |
| | plu1400 | Unnamed protein product; Highly similar to unknown protein. (71 aa) |
| | plu1414 | Unnamed protein product; Similar to unknown protein. (275 aa) |
| | plu1440 | ATP-grasp domain-containing protein; Unnamed protein product; Some similarities with putative ligase/carboxylase. (417 aa) |
| | plu1441 | Unnamed protein product; Some similarities with putative carboxylase and NikS protein involved in nikkomycin biosynthesis. (820 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (346 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa) |
| | plu1489 | Probable queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (297 aa) |
| | plu1515 | ThiF domain-containing protein; Unnamed protein product; Similar to MccB protein of Escherichia coli, involved in the production of microcin C7. (352 aa) |
| | folE | GTP cyclohydrolase I (GTP-CH-I). (219 aa) |
| | udk | Uridine kinase (uridine monophosphokinase) (pyrimidine ribonucleoside kinase). (213 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa) |
| | grxA | Glutaredoxin 1 (Grx1). (86 aa) |
| | serS | seryl-tRNA synthetase (serine--tRNA ligase) (SERRS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa) |
| | serC | 3-phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | mssA | Cytidylate kinase (CK) (cytidine monophosphate kinase) (CMP kinase) (MssA protein) (P25). (227 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa) |
| | pcnB-2 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (404 aa) |
| | pyrD | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (dhodehase) (dhodase) (dhod); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | pyrC | Dihydroorotase (DHOase); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (350 aa) |
| | plu1873 | ATP-grasp domain-containing protein; Unnamed protein product; Some similarities with NikS protein involved in antibiotic nikkomycin biosynthesis. (387 aa) |
| | plu1874 | ATP-grasp domain-containing protein; Unnamed protein product; Some similarities with Nikkomycin biosynthesis protein, carboxylase. (379 aa) |
| | plu1883 | Transket_pyr domain-containing protein; Unnamed protein product; Similar to 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) alpha/beta E1 chain CP0743. (665 aa) |
| | plu1894 | HNHc domain-containing protein; Unnamed protein product; Similar to pyocin S2 and S1. (562 aa) |
| | fliI | Flagellum-specific ATP synthase. (454 aa) |
| | fliA | RNA polymerase sigma factor for flagellar operon (Sigma-F factor) (Sigma-27) (Sigma-28); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (240 aa) |
| | plu1976 | SnoaL-like domain-containing protein; Unnamed protein product; Weakly similar to unknown protein. (133 aa) |
| | plu2030 | Universal stress protein; Unnamed protein product; Similar to unknown protein YbdQ of Escherichia coli. (142 aa) |
| | plu2032 | Universal stress protein; Unnamed protein product; Similar to unknown protein YbdQ of Escherichia coli. (145 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (420 aa) |
| | nudB | dATP pyrophosphohydrolase. (145 aa) |
| | plu2180 | Unnamed protein product; Similar to uracil phosphoribosyl transferase. (218 aa) |
| | plu2192 | ThiF domain-containing protein; Unnamed protein product; Some similarities with molybdopterin and thiamine biosynthesis protein. (372 aa) |
| | plu2197 | ATP-grasp domain-containing protein; Unnamed protein product; Similar to NikS protein involved in the biosynthesis of the peptidyl nucleoside antibiotic nikkomycin. (395 aa) |
| | plu2198 | ATP-grasp domain-containing protein; Unnamed protein product; Similar to the phosphoribosylamine--glycine ligase. (420 aa) |
| | manA | Mannose-6-phosphate isomerase (phosphomannose isomerase) (phosphohexomutase) (PMI). (390 aa) |
| | add | Adenosine deaminase (adenosine aminohydrolase); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa) |
| | plu2403 | NDK domain-containing protein; Truncated gene. Highly similar to C-terminal region of transposase; Belongs to the NDK family. (156 aa) |
| | btuR | cob(I)alamin adenolsyltransferase (corrinoid adenosyltransferase); Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (198 aa) |
| | plu2453 | Haemagg_act domain-containing protein; Unnamed protein product; Some similarities with hemagglutinin/hemolysin-related protein. Putative transmembrane protein. (1687 aa) |
| | trpE | Anthranilate synthase component I. (524 aa) |
| | trpG | Anthranilate synthase component II (Glutamine amido-transferase). (192 aa) |
| | trpD | Anthranilate synthase component II anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (332 aa) |
| | trpC | Tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase (IGPS); N-(5'-phospho-ribosyl)anthrnilate isomerase (PRAI)]. (454 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | tdk | Thymidine kinase. (201 aa) |
| | plu2500 | UDP-glucose 6-dehydrogenase; Unnamed protein product; Highly similar to probable nucleotide sugar dehydrogenase and UDP-glucose dehydrogenase. (447 aa) |
| | purU | Formyltetrahydrofolate deformylase (Formyl-FH(4) hydrolase); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa) |
| | plu2512 | Epimerase domain-containing protein; Unnamed protein product; Similar to unknown protein and to probable UDP glucose 4-epimerase. (321 aa) |
| | pncA | Pyrazinamidase/nicotinamidase [Includes: Pyrazinamidase (PZASE); Nicotinamidase (Nicotine deamidase)]. (212 aa) |
| | pdxY | Pyridoxamine kinase (PM kinase); Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (287 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (PNPOX); Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (217 aa) |
| | purR | Purine nucleotide synthesis repressor protein PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa) |
| | holE | DNA polymerase III, theta subunit. (76 aa) |
| | pabB | P-aminobenzoate synthase component I. (456 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | entB | Isochorismatase (2,3-dihydro-2,3-dihydroxybenzoate synthetase). (217 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase (5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide synthase); Belongs to the SAICAR synthetase family. (237 aa) |
| | upp | Uracil phosphoribosyltransferase (UMP pyrophosphorylase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (phosphoribosyl-aminoimidazole synthetase) (AIR synthase). (346 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | plu2766 | ATP-grasp domain-containing protein; Unnamed protein product; Weakly similar to putative ligase/carboxylase. (412 aa) |
| | plu2768 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (451 aa) |
| | plu2772 | A_deaminase domain-containing protein; Unnamed protein product; Similar to adenosine deaminase. (335 aa) |
| | thiD | Phosphomethylpyrimidine kinase (HMP-phosphate kinase). (265 aa) |
| | plu2793 | GTP_cyclohydroI domain-containing protein; Unnamed protein product; Some similarities with GTP cyclohydrolase I precursor. (234 aa) |
| | plu2794 | Unnamed protein product; Some similarities with 6-pyruvoyl tetrahydrobiopterin synthase. (194 aa) |
| | plu2795 | Transket_pyr domain-containing protein; Unnamed protein product; Similar to 3-methyl-2-oxobutanoate dehydrogenase (lipoamide). Putative transmembrane protein. (650 aa) |
| | plu2799 | HPPK domain-containing protein; Unnamed protein product; Some similarities with 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (180 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | thiK | Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (287 aa) |
| | holB | DNA-directed DNA polymerase III delta' chain. (329 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa) |
| | pabC | 4-amino-4-deoxychorismate lyase (ADC lyase) (ADCL). (274 aa) |
| | plu2916 | Prim_Zn_Ribbon domain-containing protein; Unnamed protein product; Some similarities with alpha replication protein of prophage. (318 aa) |
| | plu2964 | Corrinoid adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (185 aa) |
| | plu2965 | Unnamed protein product; Highly similar to the N-terminal region of siroheme synthase activity. (222 aa) |
| | cobD | Aminotransferase CobD. (358 aa) |
| | plu2968 | TP_methylase domain-containing protein; Unnamed protein product; Highly similar to the C-terminal region of siroheme synthase activity; Belongs to the precorrin methyltransferase family. (261 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (349 aa) |
| | cobC | Alpha-ribazole-5'-phosphate phosphatase; Belongs to the phosphoglycerate mutase family. (205 aa) |
| | cobS | Cobalamin [5'-phosphate] synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (248 aa) |
| | cobU | Bifunctional cobalamin biosynthesis protein cobU [Includes: Cobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (181 aa) |
| | cbiP | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (512 aa) |
| | cbiL | Precorrin-2 C20-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Belongs to the precorrin methyltransferase family. (237 aa) |
| | cbiK | Cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (264 aa) |
| | cbiJ | Precorrin-6X reductase. (261 aa) |
| | cbiH | Precorrin-3B C17-methyltransferase (precorrin-3 methyltransferase) (precorrin-3 methylase). (241 aa) |
| | cbiG | Cobalamin biosynthesis protein G (CbiG). (353 aa) |
| | cbiF | Precorrin-4 C11-methyltransferase (precorrin-3-methylase). (257 aa) |
| | cbiT | Precorrin-8W decarboxylase. (189 aa) |
| | cbiE | Cobalt-precorrin-7 (C5)-methyltransferase; Precorrin-6Y C5,15-methyltransferase [decarboxylating](precorrin-6 methyltransferase)(precorrin-6Y methylase). (200 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (378 aa) |
| | cbiC | Precorrin-8X methylmutase (Precorrin isomerase). (210 aa) |
| | cbiB | CbiB protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa) |
| | cbiA | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (460 aa) |
| | plu3043 | Unnamed protein product; Some similarities with prephenate dehydratase. (192 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase 1 beta chain (ribonucleotide reductase 1) (B2 protein) (R2 protein). (376 aa) |
| | plu3092 | 5'-deoxynucleotidase plu3092; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa) |
| | ackA | Acetate kinase (acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | pta | Phosphate acetyltransferase (phosphotransacetylase); Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (713 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | folC | Dihydrofolate synthase/folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (432 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase beta chain); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (314 aa) |
| | pdxB | Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (375 aa) |
| | aroC | Chorismate synthase (EC 4.6.1.4) (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | plu3302 | ATPase_AAA_core domain-containing protein; Unnamed protein product; Similar to unknown protein. (335 aa) |
| | nadE | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (540 aa) |
| | purL | Phosphoribosylformylglycineamide synthetase (formylglycineamide ribonucleotide synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1298 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ (PNP synthase); Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa) |
| | rpoE | RNA polymerase sigma-E factor (sigma-24); Belongs to the sigma-70 factor family. ECF subfamily. (189 aa) |
| | nadB | L-aspartate oxidase (quinolinate synthetase B); Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa) |
| | ppnK | Probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | plu3471 | Unnamed protein product; Similar to replicative DNA helicase of Bacteriophage. (455 aa) |
| | plu3472 | AAA domain-containing protein; Unnamed protein product; Some similarities with DNA replication protein DnaC of bacteriophage. (194 aa) |
| | plu3557 | HD_domain domain-containing protein; Unnamed protein product; Similar to unknown protein. (201 aa) |
| | plu3562 | Unnamed protein product; Similar to dehydrogenase PapC of Streptomyces pristinaespiralis. (295 aa) |
| | plu3564 | Unnamed protein product; Weakly similar to PapB protein and to chorismate mutase/prephenate dehydrogenase. (119 aa) |
| | plu3580 | ZnF_CHCC domain-containing protein; Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1104 aa) |
| | plu3589 | Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1104 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase [carboxylating] (quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase); Belongs to the NadC/ModD family. (296 aa) |
| | coaE | Dephospho-CoA kinase (Dephosphocoenzyme A kinase); Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | plu3689 | Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1104 aa) |
| | plu3697 | ZnF_CHCC domain-containing protein; Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1104 aa) |
| | plu3705 | ZnF_CHCC domain-containing protein; Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1104 aa) |
| | plu3714 | ZnF_CHCC domain-containing protein; Unnamed protein product; Highly similar to unknown protein of Photorhabdus and some similarities with DNA primase. (1105 aa) |
| | sctN | Type III secretion component protein SctN; Similar to Yops secretion ATPase. (440 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit (AIR carboxylase) (AIRC); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit (AIR carboxylase) (AIRC); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (365 aa) |
| | hemH | Ferrochelatase (protoheme ferro-lyase) (heme synthetase); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (325 aa) |
| | adk | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | dnaX | DNA polymerase III subunit Tau [Contains: DNA polymerase III subunit gamma]; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (658 aa) |
| | apt | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | priC | Primosomal replication factor N''. (180 aa) |
| | queC | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (232 aa) |
| | bolA | BolA protein; Belongs to the BolA/IbaG family. (104 aa) |
| | cyoE | Protoheme IX farnesyltransferase (heme O synthase); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (294 aa) |
| | thiI | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | thiL | Thiamine-monophosphate kinase (thiamine-phosphate kinase); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (329 aa) |
| | nusB | N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (138 aa) |
| | tgt | Queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowin [...] (374 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (queuosine biosynthesis protein QueA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (355 aa) |
| | plu3917 | DHO_dh domain-containing protein; Catalyzes the conversion of dihydroorotate to orotate. (289 aa) |
| | plu3961 | Unnamed protein product; Hypothetical gene. (52 aa) |
| | rfaE | ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa) |
| | folB | Dihydroneopterin aldolase (DHNA); Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (117 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (581 aa) |
| | rpoD | RNA polymerase sigma factor rpoD (Sigma-70); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (614 aa) |
| | plu4026 | Unnamed protein product; Hypothetical gene. (162 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa) |
| | rpoN | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (480 aa) |
| | aroQ | 3-dehydroquinate dehydratase (3-dehydroquinase) (Type II DHQase); Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | accC | Biotin carboxylase (A subunit of acetyl-CoA carboxylase) (ACC); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | plu4079 | Unnamed protein product; Sone similarities in the N-terminal region with dehydrogenase. (721 aa) |
| | rpoH | RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (285 aa) |
| | plu4110 | Probable queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (224 aa) |
| | plu4177 | Pyosin/cloacin_T_dom domain-containing protein; Unnamed protein product; Some similarities with killer protein of pyocin S3 and highly similar to Photorhabdus luminescens unknown protein. (553 aa) |
| | holD | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (137 aa) |
| | folD | Bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa) |
| | plu4348 | Unnamed protein product; Similar to the C-terminal region of groupII intron-associated maturase. (62 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (469 aa) |
| | plu4388 | Unnamed protein product; Unknown protein. (298 aa) |
| | hemG | Protoporphyrinogen oxidase (PPO). (178 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. (337 aa) |
| | udp | Uridine phosphorylase (UDRPase); Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (251 aa) |
| | fecI | RNA polymerase sigma factor; Truncated transposase, IS30 family (ISPlu1-p); Belongs to the sigma-70 factor family. ECF subfamily. (173 aa) |
| | holC | DNA polymerase III, chi subunit. (149 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain (aspartate transcarbamylase) (ATCase); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (307 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa) |
| | nrdG | Anaerobic ribonucleoside-triphosphate reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | nusA | N utilization substance protein A (nusA protein) (L factor); Participates in both transcription termination and antitermination. (502 aa) |
| | folP | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (281 aa) |
| | plu4563 | ATP-grasp domain-containing protein; Unnamed protein product; Some similarities with unknown protein. (436 aa) |
| | priB | Primosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (105 aa) |
| | purA | Adenylosuccinate synthetase (IMP--aspartate ligase) (ADSS) (AMPSASE); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | queG | Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (393 aa) |
| | plu4618 | Unnamed protein product; Highly similar to unknown protein YigL of Escherichia coli. (266 aa) |
| | cyaA | Adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Belongs to the adenylyl cyclase class-1 family. (856 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa) |
| | hemD | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | hemY | HemY protein; Involved in a late step of protoheme IX synthesis. (412 aa) |
| | rho | Transcription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa) |
| | gppA | Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (500 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | zntR | Zn(II)-responsive transcriptional regulator of ZntA. (138 aa) |
| | rpoA | RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | coaA | Pantothenate kinase (pantothenic acid kinase). (316 aa) |
| | priA | Primosomal protein N' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (739 aa) |
| | wblW | WblW protein; Similar to putative sugar kinase. (342 aa) |
| | rfaD | ADP-L-glycero-D-manno-heptose-6-epimerase (ADP-glyceromanno-heptose 6-epimerase); Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. (312 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | pyrE | Orotate phosphoribosyltransferase (OPRT) (OPRTASE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | plu4876 | Reverse transcriptase domain-containing protein; Unnamed protein product; Similar to RNA-directed DNA polymerase. (393 aa) |
| | selA | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (463 aa) |
