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fba fba upp upp glpF glpF tdk tdk glpK glpK MG_039 MG_039 ptsH ptsH deoD deoD deoC deoC pdp pdp cdd cdd manB manB prs prs fruA fruA fruK fruK tkt tkt ptsG ptsG gmk gmk MG_108 MG_108 MG_109 MG_109 rsgA rsgA pgi pgi rpe rpe pgsA pgsA MG_116 MG_116 MG_117 MG_117 galE galE MG_119 MG_119 MG_120 MG_120 MG_121 MG_121 MG_123 MG_123 MG_125 MG_125 glf glf adk adk MG_207 MG_207 MG_211 MG_211 plsC plsC scpA scpA scpB scpB pfk pfk plsY plsY MG_263 MG_263 coaE coaE lplA lplA lpdA lpdA pdhC pdhC pdhB pdhB pdhA pdhA nox nox apt apt MG_293 MG_293 smc smc pta pta pgk pgk gap gap ackA ackA plsX plsX udk udk MG_385 MG_385 rpiB rpiB eno eno ptsI ptsI gpmI gpmI tpiA tpiA cdsA cdsA MG_450 MG_450 MG_452 MG_452 galU galU hpt hpt MG_459 MG_459 ldh ldh MG_480 MG_480 acpS acpS
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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fbaFructose-1,6-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (288 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (206 aa)
glpFGlycerol uptake facilitator; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). (258 aa)
tdkThymidine kinase; Identified by similarity to SP:Q03221; match to protein family HMM PF00265. (213 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (508 aa)
MG_039FAD-dependent glycerol-3-phosphate dehydrogenase, putative; Identified by similarity to GB:AAP56366.1; match to protein family HMM PF01266. (384 aa)
ptsHPhosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (88 aa)
deoDPurine nucleoside phosphorylase; Identified by similarity to SP:P09743; match to protein family HMM PF01048; match to protein family HMM TIGR00107; Belongs to the PNP/UDP phosphorylase family. (238 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa)
pdpPyrimidine-nucleoside phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. (421 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (130 aa)
manBPhosphoglucomutase/phosphomannomutase, putative; Identified by similarity to EGAD:56902; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; Belongs to the phosphohexose mutase family. (550 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (332 aa)
fruAPTS system, fructose-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. (680 aa)
fruK1-phosphofructokinase, putative; Identified by similarity to GB:AAF08321.1; match to protein family HMM PF00294; Belongs to the carbohydrate kinase PfkB family. (303 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (648 aa)
ptsGPTS system, glucose-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport. (908 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (189 aa)
MG_108Protein phosphatase 2C, putative; Identified by similarity to EGAD:57254; match to protein family HMM PF00481. (260 aa)
MG_109Serine/threonine protein kinase, putative; MG109 has 1 transmembrane region; identified by similarity to GB:AAL58474.1; match to protein family HMM PF00069; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (387 aa)
rsgARibosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (278 aa)
pgiGlucose-6-phosphate isomerase; MG111 has 1 transmembrane region; identified by similarity to SP:P81181; match to protein family HMM PF00342. (433 aa)
rpeRibulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (209 aa)
pgsACDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (236 aa)
MG_116Conserved hypothetical protein; Identified by similarity to EGAD:57240. (251 aa)
MG_117Conserved hypothetical protein; MG117 has some similarity to the superoxide dismutase (Mn/Fe family), C-terminal domain; identified by similarity to EGAD:57238. (214 aa)
galEUDP-glucose 4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity). (340 aa)
MG_119ABC transporter, ATP-binding protein; Part of the ABC transporter complex involved in carbohydrates import. Probably responsible for energy coupling to the transport system (By similarity). (564 aa)
MG_120This is part of an ABC transporter cassette. The permeases (MG120 and MG121) are similar to branched chain amino acid transporters; however the ATP-binding protein is much more similar to a galactoside transporter. MG120 has 9 transmembrane regions; identified by similarity to EGAD:57232; match to protein family HMM PF02653. (520 aa)
MG_121This is part of an ABC transporter cassette. The permeases (MG120 and MG121) are similar to branched chain amino acid transporters; however the ATP-binding protein is much more similar to a galactoside transporter. MG121 has 8 transmembrane regions; identified by similarity to EGAD:57230; match to protein family HMM PF02653. (306 aa)
MG_123Conserved hypothetical protein; MG123 has 1 transmembrane region; identified by similarity to EGAD:57226. (471 aa)
MG_125Cof-like hydrolase, putative; Identified by similarity to EGAD:57222; match to protein family HMM PF00702; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484. (285 aa)
glfUDP-galactopyranose mutase; Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate. (404 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
MG_207Identified by similarity to EGAD:57314; match to protein family HMM PF00149; match to protein family HMM TIGR00040; Belongs to the metallophosphoesterase superfamily. YfcE family. (167 aa)
MG_211Conserved hypothetical protein; Identified by similarity to EGAD:57137. (147 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase, putative; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (268 aa)
scpASegregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity). (471 aa)
scpBSegregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (207 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (323 aa)
plsYMembrane protein, putative; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (239 aa)
MG_263Cof-like hydrolase; Identified by similarity to EGAD:57126; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484. (291 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)
lplALipoyltransferase/lipoate-protein ligase, putative; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. (336 aa)
lpdADihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (457 aa)
pdhCDihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (384 aa)
pdhBPyruvate dehydrogenase component E1, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (326 aa)
pdhAPyruvate dehydrogenase component E1, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (358 aa)
noxNADH oxidase; Catalyzes the four-electron reduction of molecular oxygen to water; Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family. (478 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)
MG_293Glycerophosphoryl diester phosphodiesterase family protein; MG293 and MG385 comprise a parrologous gene family. Both can be disrupted (Glass et al. 2005); identified by similarity to EGAD:56951; match to protein family HMM PF03009; To glycerophosphoryl diester phosphodiesterases (EC 3.1.4.46). (244 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (982 aa)
ptaPhosphate acetyltransferase; Identified by similarity to SP:P39646; match to protein family HMM PF01515; match to protein family HMM TIGR00651. (320 aa)
pgkPhosphoglycerate kinase; Identified by similarity to SP:P36204; match to protein family HMM PF00162. (411 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (337 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (393 aa)
plsXFatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (328 aa)
udkUridine kinase; Identified by similarity to EGAD:57059; match to protein family HMM PF00485; match to protein family HMM TIGR00235. (213 aa)
MG_385Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. MG293 and MG385 comprise a parrologous gene family. Both can be disrupted when grown on SP-4 media(Glass et al. 2005); identified by similarity to SP:P37965; match to protein family HMM PF03009. (236 aa)
rpiBRibose 5-phosphate isomerase B; Catalyzes the interconversion of ribulose-5-P and ribose-5-P. Belongs to the LacAB/RpiB family. (152 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (458 aa)
ptsIPhosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (572 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (507 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (244 aa)
cdsAPhosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. (397 aa)
MG_450degV family protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. (290 aa)
MG_452Membrane protein, putative; MG452 has 6 transmembrane regions; identified by similarity to EGAD:56932; match to protein family HMM PF07667. (261 aa)
galUUTP-glucose-1-phosphate uridylyltransferase; May play a role in stationary phase survival; Belongs to the UDPGP type 2 family. (292 aa)
hptHypoxanthine phosphoribosyltransferase; Identified by similarity to SP:Q02522; match to protein family HMM PF00156; match to protein family HMM TIGR01203. (175 aa)
MG_459Conserved hypothetical protein; MG459 may encode a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; however M. genitalium does not synthesize isoprenyl pyrophosphate via deoxyxylulose; identified by similarity to EGAD:56901; match to protein family HMM PF02542. (169 aa)
ldhL-lactate dehydrogenase/malate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (312 aa)
MG_480Conserved hypothetical protein; old_locus_tag=MG210.1; identified by similarity to EGAD:57145. (219 aa)
acpSHolo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (114 aa)
Your Current Organism:
Mycoplasma genitalium
NCBI taxonomy Id: 243273
Other names: M. genitalium G37, Mycoplasma genitalium ATCC 33530, Mycoplasma genitalium G37, Mycoplasma genitalium str. G37, Mycoplasma genitalium strain G37
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