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rplO rplO rpmJ rpmJ rpsK rpsK rplQ rplQ nrnA nrnA rpmI rpmI rplU rplU dnaG dnaG rpmE rpmE MG_269 MG_269 rpmG rpmG MG_349 MG_349 MG_353 MG_353 rplJ rplJ rplL rplL rpmF rpmF MG_371 MG_371 udk udk MG_397 MG_397 rpsI rpsI rplM rplM rpsO rpsO rpmB rpmB rpsP rpsP MG_461 MG_461 rpL34 rpL34 rpmG-2 rpmG-2 rpsU rpsU rpsT rpsT MG_010 MG_010 MG_018 MG_018 rnmV rnmV rpsB rpsB rpsG rpsG rpsF rpsF rpsR rpsR dnaB dnaB topA topA MG_134 MG_134 rpsJ rpsJ rplC rplC rplW rplW rplB rplB rpsS rpsS rpsC rpsC rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsN rpsN rpsH rpsH rplR rplR rpsE rpsE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (150 aa)
rpmJRibosomal protein L36; Identified by similarity to SP:P21194; match to protein family HMM PF00444; match to protein family HMM TIGR01022; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome. (121 aa)
rplQRibosomal protein L17; Identified by similarity to EGAD:41362; match to protein family HMM PF01196; match to protein family HMM TIGR00059. (123 aa)
nrnAPhosphoesterase, DHH subfamily 1; Bifunctional enzyme which has both oligoribonuclease and pAp- phosphatase activities. Degrades RNA and DNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for longer oligomers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP (By similarity); Belongs to the NrnA oligoribonuclease family. (318 aa)
rpmIRibosomal protein L35; Identified by similarity to SP:P55874; match to protein family HMM PF01632; match to protein family HMM TIGR00001; Belongs to the bacterial ribosomal protein bL35 family. (59 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (100 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (607 aa)
rpmERibosomal protein L31; Binds the 23S rRNA; Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily. (97 aa)
MG_269Conserved hypothetical protein; Identified by similarity to EGAD:57097. (340 aa)
rpmGRibosomal protein L33; Identified by similarity to EGAD:57100; match to protein family HMM PF00471; match to protein family HMM TIGR01023; Belongs to the bacterial ribosomal protein bL33 family. (53 aa)
MG_349Conserved hypothetical protein; Identified by similarity to EGAD:56850. (404 aa)
MG_353DNA-binding protein HU, putative; Identified by similarity to GB:AAK52476.1. (109 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (162 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
rpmFRibosomal protein L32; Identified by similarity to SP:O34687; match to protein family HMM PF01783; match to protein family HMM TIGR01031; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
MG_371DHH family protein; Identified by similarity to EGAD:57119; match to protein family HMM PF01368; match to protein family HMM PF02272; Belongs to the mgp1/MG371 family. (324 aa)
udkUridine kinase; Identified by similarity to EGAD:57059; match to protein family HMM PF00485; match to protein family HMM TIGR00235. (213 aa)
MG_397Conserved hypothetical protein; MG397 has 1 transmembrane region; identified by similarity to EGAD:35551. (566 aa)
rpsIRibosomal protein S9; Identified by similarity to SP:P21470; match to protein family HMM PF00380; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (146 aa)
rpsORibosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (86 aa)
rpmBRibosomal protein L28; Identified by similarity to SP:P37807; match to protein family HMM PF00830; match to protein family HMM TIGR00009; Belongs to the bacterial ribosomal protein bL28 family. (64 aa)
rpsPRibosomal protein S16; Identified by similarity to SP:P21474; match to protein family HMM PF00886; match to protein family HMM TIGR00002. (95 aa)
MG_461HD domain protein; Identified by similarity to EGAD:56887; match to protein family HMM PF01966. (425 aa)
rpL34Ribosomal protein L34; Identified by similarity to SP:P02437; match to protein family HMM PF00468; match to protein family HMM TIGR01030; Belongs to the bacterial ribosomal protein bL34 family. (48 aa)
rpmG-2Ribosomal protein L33 type 2; old_locus_tag=MG055.1; identified by similarity to SP:Q06798; match to protein family HMM TIGR01023; Belongs to the bacterial ribosomal protein bL33 family. (48 aa)
rpsU30S ribosomal protein S21; old_locus_tag=MG210.2; identified by match to protein family HMM TIGR00030; Belongs to the bacterial ribosomal protein bS21 family. (62 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
MG_010DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. (218 aa)
MG_018Helicase SNF2 family, putative; Identified by similarity to EGAD:56776; match to protein family HMM PF00176; match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04434. (1031 aa)
rnmVSmall primase-like protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity); Belongs to the ribonuclease M5 family. (178 aa)
rpsBRibosomal protein S2; Identified by similarity to SP:P21464; match to protein family HMM PF00318; match to protein family HMM TIGR01011; Belongs to the universal ribosomal protein uS2 family. (284 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (155 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (208 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (105 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. (468 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (709 aa)
MG_134Conserved hypothetical protein; Identified by similarity to EGAD:57204; match to protein family HMM PF02575; match to protein family HMM TIGR00103. (100 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (106 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (257 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (106 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (285 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (87 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (268 aa)
rpmCRibosomal protein L29; Identified by similarity to SP:P04457; match to protein family HMM PF00831; match to protein family HMM TIGR00012; Belongs to the universal ribosomal protein uL29 family. (200 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (85 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXRibosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (108 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rpsNRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (141 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (115 aa)
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (211 aa)
Your Current Organism:
Mycoplasma genitalium
NCBI taxonomy Id: 243273
Other names: M. genitalium G37, Mycoplasma genitalium ATCC 33530, Mycoplasma genitalium G37, Mycoplasma genitalium str. G37, Mycoplasma genitalium strain G37
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