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lolD lolD TP_0600 TP_0600 potA potA mglA mglA mltG mltG lnt2 lnt2 secF secF secD secD fliG2 fliG2 fliF fliF ftsA ftsA secA secA mraY mraY rfuD rfuD rfuC rfuC flhB flhB fliM fliM motB motB motA motA ftsH ftsH rfuB rfuB apbE apbE dacA dacA lgt lgt yidC yidC ftsK ftsK rfuA rfuA glpQ glpQ lnt1 lnt1 secE secE secY secY TP_0036 TP_0036 TP_0035 TP_0035 rodA rodA lepA lepA murJ murJ murG murG era era TP_0574 TP_0574
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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lolDABC transporter, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (226 aa)
TP_0600Zinc protease, putative; Similar to GB:L42023 SP:P44936 PID:1006037 PID:1221023 PID:1205165 percent identity: 32.94; identified by sequence similarity; putative; Belongs to the peptidase M50B family. (450 aa)
potASpermidine/putrescine ABC transporter, ATP-binding protein (potA); Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (379 aa)
mglAMethylgalactoside ABC transporter, ATP binding protein (mglA); Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system. (496 aa)
mltGConserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (344 aa)
lnt2Apolipoprotein N-acyltransferase (cutE); Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (559 aa)
secFProtein-export membrane protein (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (420 aa)
secDProtein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (583 aa)
fliG2Flagellar motor switch protein (fliG-2); FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (352 aa)
fliFFlagellar basal-body M ring protein (fliF); The M ring may be actively involved in energy transduction. (567 aa)
ftsACell division protein (ftsA); Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (414 aa)
secAPreprotein translocase subunit (secA); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (916 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase (mraY); First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (363 aa)
rfuDConserved hypothetical integral membrane protein; Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for the translocation of the substrate across the membrane. (313 aa)
rfuCConserved hypothetical integral membrane protein; Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for the translocation of the substrate across the membrane. (377 aa)
flhBFlagellar biosynthetic protein (flhB); Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity); Belongs to the type III secretion exporter family. (376 aa)
fliMFlagellar motor switch protein (fliM); FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). (344 aa)
motBFlagellar motor rotation protein (motB); MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity). (238 aa)
motAFlagellar motor rotation protein (motA); MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity). (259 aa)
ftsHCell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (609 aa)
rfuBRibose/galactose ABC transporter, ATP-binding protein (rbsA-1); Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for energy coupling to the transport system. (516 aa)
apbEConserved hypothetical protein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein (By similarity). Displays FAD pyrophosphatase activity in vitro, hydrolyzing FAD into FMN and AMP. (362 aa)
dacAConserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (273 aa)
lgtProlipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (332 aa)
yidCMembrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (665 aa)
ftsKCell division protein, putative; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Belongs to the FtsK/SpoIIIE/SftA family. (799 aa)
rfuAExported protein (tpn38b); Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Binds riboflavin. (343 aa)
glpQGlycerophosphoryldiester phosphodiesterase (glpQ); Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. (356 aa)
lnt1Apolipoprotein N-acyltransferase, putative; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (546 aa)
secEPreprotein translocase subunit (secE); Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (59 aa)
secYPreprotein translocase subunit (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (450 aa)
TP_0036ABC transporter, permease protein; Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal; Belongs to the ABC-3 integral membrane protein family. (266 aa)
TP_0035ABC transporter, ATP-binding protein; Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. (238 aa)
rodARod shape-determining protein (rodA); Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (433 aa)
lepAGTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (605 aa)
murJVirulence factor (mviN); Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (526 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (384 aa)
eraGTP-binding protein (era); An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (319 aa)
TP_0574Carboxypeptidase, 47 kDa; A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus. Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates. May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete (Probable). Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, no [...] (434 aa)
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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