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lpxM lpxM lpxL lpxL slmA slmA VC_0233 VC_0233 lptD lptD bamD bamD bamB bamB bamE bamE lptE lptE lpxH lpxH kdsB kdsB VC_1876 VC_1876 lpxK lpxK msbA msbA VC_1880 VC_1880 bamC bamC kdsA kdsA lpxB lpxB lpxA lpxA lpxD lpxD bamA bamA lpxC lpxC VC_2499 VC_2499 VC_2500 VC_2500 VC_2515 VC_2515 VC_2516 VC_2516 VC_2517 VC_2517 VC_2518 VC_2518 VC_2519 VC_2519 VC_2520 VC_2520 VC_2521 VC_2521 VC_2522 VC_2522 VC_2523 VC_2523 VC_2524 VC_2524 lptC lptC lptA lptA VC_2528 VC_2528 VC_2530 VC_2530 VC_2531 VC_2531 VC_2532 VC_2532 VC_2534 VC_2534 VC_A1097 VC_A1097
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxMLipid A biosynthesis (kdo)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (325 aa)
lpxLLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (318 aa)
slmATranscriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (210 aa)
VC_02333-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (439 aa)
lptDOrganic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (787 aa)
bamDConserved hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (253 aa)
bamBConserved hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (386 aa)
bamESmall protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (136 aa)
lptERare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (213 aa)
lpxHConserved hypothetical protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (242 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (252 aa)
VC_1876Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0434 family. (59 aa)
lpxKTetraacyldisaccharide 4`-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (336 aa)
msbATransport ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. (582 aa)
VC_1880Conserved hypothetical protein; Identified by Glimmer2; putative. (176 aa)
bamCLipoprotein-34 NlpB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (339 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Similar to SP:P17579 GB:X05552 PID:940498 PID:968934 GB:U00096; identified by sequence similarity; putative; Belongs to the KdsA family. (283 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (379 aa)
lpxAacyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
lpxDUDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (351 aa)
bamASurface antigen; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (803 aa)
lpxCUDP-3-O-3-hydroxymyristoyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
VC_2499Conserved hypothetical protein; Identified by Glimmer2; putative. (356 aa)
VC_2500Conserved hypothetical protein; Identified by Glimmer2; putative. (366 aa)
VC_2515BolA/YrbA family protein; Similar to SP:P43781 PID:606128 GB:U00096 PID:1789581; identified by sequence similarity; putative; Belongs to the BolA/IbaG family. (84 aa)
VC_2516Anti-sigma B factor antagonist, putative; Similar to SP:P45389 PID:606129 GB:U00096 PID:1789582; identified by sequence similarity; putative. (109 aa)
VC_2517Conserved hypothetical protein; Identified by Glimmer2; putative. (213 aa)
VC_2518Conserved hypothetical protein; Identified by Glimmer2; putative. (163 aa)
VC_2519Conserved hypothetical protein; Identified by Glimmer2; putative. (258 aa)
VC_2520ABC transporter, ATP-binding protein; Similar to SP:P45393 PID:606133 GB:U00096 PID:1789586; identified by sequence similarity; putative. (267 aa)
VC_2521Hypothetical protein; Identified by Glimmer2; putative. (63 aa)
VC_2522Conserved hypothetical protein; Identified by Glimmer2; putative. (332 aa)
VC_2523Conserved hypothetical protein; Identified by Glimmer2; putative. (326 aa)
VC_2524Conserved hypothetical protein; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (185 aa)
lptCHypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (187 aa)
lptAConserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (179 aa)
VC_2528ABC transporter, ATP-binding protein; Similar to PID:2317737; identified by sequence similarity; putative. (241 aa)
VC_2530Sigma-54 modulation protein, putative; Similar to PID:2317739; identified by sequence similarity; putative. (95 aa)
VC_2531PTS system, nitrogen regulatory IIA component; Similar to PID:2317740; identified by sequence similarity; putative. (148 aa)
VC_2532Conserved hypothetical protein; Displays ATPase and GTPase activities. (286 aa)
VC_2534Magnesium transporter; Acts as a magnesium transporter. (453 aa)
VC_A1097Conserved hypothetical protein; Identified by Glimmer2; putative. (101 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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