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VC_0072 VC_0072 cdpA cdpA VC_0398 VC_0398 VC_0512 VC_0512 VC_0622 VC_0622 VC_0653 VC_0653 VC_1349 VC_1349 VC_1367 VC_1367 VC_1398 VC_1398 VC_1406 VC_1406 VC_1445 VC_1445 VC_1602 VC_1602 VC_1653 VC_1653 VC_1710 VC_1710 VC_1831 VC_1831 VC_2006 VC_2006 VC_2369 VC_2369 VC_2370 VC_2370 VC_2453 VC_2453 VC_2750 VC_2750 VC_A0080 VC_A0080 cqsS cqsS VC_A0658 VC_A0658 VC_A0709 VC_A0709 VC_A0785 VC_A0785 VC_A0939 VC_A0939 VC_A0954 VC_A0954 VC_A1086 VC_A1086
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VC_0072Sensory box/GGDEF family protein; Similar to PID:1651932; identified by sequence similarity; putative. (768 aa)
cdpAGGDEF family protein; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. CdpA functions as a repressor of biofilm formation but has no effect on colonization of the infant mouse small intestine. Does not possess diguanylate cyclase (DGC) a [...] (829 aa)
VC_0398MSHA biogenesis protein MshH; Similar to SP:P13518 GB:M22055 PID:606192 PID:1128966 GB:U00096; identified by sequence similarity; putative. (673 aa)
VC_0512Methyl-accepting chemotaxis protein; Similar to GB:X61367 PID:48195; identified by sequence similarity; putative. (529 aa)
VC_0622Sensory box sensor histidine kinase/response regulator; Similar to PID:939724; identified by sequence similarity; putative. (1177 aa)
VC_0653c-di-GMP phosphodiesterase A-related protein; Similar to GP:3659618; identified by sequence similarity; putative. (684 aa)
VC_1349Sensory box sensor histidine kinase/response regulator; Similar to PID:1653075; identified by sequence similarity; putative. (1331 aa)
VC_1367GGDEF family protein; Similar to PID:633121; identified by sequence similarity; putative. (667 aa)
VC_1398Chemotaxis protein CheY; Similar to PID:2292999; identified by sequence similarity; putative. (124 aa)
VC_1406Methyl-accepting chemotaxis protein; Similar to GB:X61367 PID:48195; identified by sequence similarity; putative. (438 aa)
VC_1445Sensor histidine kinase/response regulator; Similar to PID:1653075; identified by sequence similarity; putative. (572 aa)
VC_1602Chemotaxis protein CheV; Similar to SP:P37599 GB:U05345 GB:Z29584 PID:453378 PID:580837; identified by sequence similarity; putative. (328 aa)
VC_1653Sensory box sensor histidine kinase/response regulator VieS; Similar to GP:3123890; identified by sequence similarity; putative. (1146 aa)
VC_1710Conserved hypothetical protein; Identified by Glimmer2; putative. (818 aa)
VC_1831Sensor histidine kinase; Similar to GB:U07069 PID:459205 SP:P54302; identified by sequence similarity; putative. (736 aa)
VC_2006Chemotaxis protein CheV; Similar to GB:AE000511 PID:2313494; identified by sequence similarity; putative. (314 aa)
VC_2369Sensor histidine kinase FexB; Similar to SP:P22763 GB:X53315 PID:40951 PID:606149 GB:U00096; identified by sequence similarity; putative. (785 aa)
VC_2370Sensory box/GGDEF family protein; Similar to PID:1652133; identified by sequence similarity; putative. (579 aa)
VC_2453Sensor histidine kinase/response regulator; Similar to GB:D10888 SP:P26607 PID:216535 PID:882680 GB:U00096; identified by sequence similarity; putative. (927 aa)
VC_2750GGDEF family protein; Similar to PID:1653584; identified by sequence similarity; putative. (849 aa)
VC_A0080GGDEF family protein; Similar to GP:6759486; identified by sequence similarity; putative. (607 aa)
cqsSSensor histidine kinase/response regulator LuxN; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO. (686 aa)
VC_A0658Methyl-accepting chemotaxis protein; Similar to GB:X61367 PID:48195; identified by sequence similarity; putative. (536 aa)
VC_A0709Sensor protein TorS; Similar to SP:P39453 PID:1122856 GB:U00096 PID:1787227; identified by sequence similarity; putative. (1020 aa)
VC_A0785GGDEF family protein; Similar to PID:1651932; identified by sequence similarity; putative. (627 aa)
VC_A0939Sensory box/GGDEF family protein; Similar to PID:1001780 PID:1001789; identified by sequence similarity; putative. (321 aa)
VC_A0954Chemotaxis protein CheV, putative; Similar to PID:1165186; identified by sequence similarity; putative. (306 aa)
VC_A1086Response regulator; Similar to PID:1653310; identified by sequence similarity; putative. (568 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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