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rraB rraB VC_0648 VC_0648 mutH mutH syd syd VC_0904 VC_0904 VC_1099 VC_1099 VC_1496 VC_1496 proQ proQ fadR fadR VC_2039 VC_2039 VC_2040 VC_2040 VC_2041 VC_2041 seqA seqA dam dam metJ metJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rraBConserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. (140 aa)
VC_0648Conserved hypothetical protein; May be involved in cell division. (303 aa)
mutHDNA mismatch repair protein MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. (221 aa)
sydSyd protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. (198 aa)
VC_0904Conserved hypothetical protein; Identified by Glimmer2; putative. (258 aa)
VC_1099Conserved hypothetical protein; Identified by Glimmer2; putative. (152 aa)
VC_1496Tail-specific protease; Similar to GP:216618; identified by sequence similarity; putative. (665 aa)
proQConserved hypothetical protein; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. (208 aa)
fadRFatty acid metabolism regulator protein; Multifunctional regulator of fatty acid metabolism. (279 aa)
VC_2039Conserved hypothetical protein; Identified by Glimmer2; putative. (333 aa)
VC_2040Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0352 family. (71 aa)
VC_2041Conserved hypothetical protein; Identified by Glimmer2; putative. (600 aa)
seqAseqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. (177 aa)
damDNA adenine methylase; Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair; Belongs to the N(4)/N(6)-methyltransferase family. (277 aa)
metJMet repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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