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VC_1442 VC_1442 nhaA nhaA VC_1634 VC_1634 VC_1653 VC_1653 VC_1655 VC_1655 VC_1751 VC_1751 VC_1821 VC_1821 VC_1822 VC_1822 VC_1826 VC_1826 VC_1863 VC_1863 nhaB nhaB VC_2031 VC_2031 VC_2077 VC_2077 znuC znuC VC_2130 VC_2130 copA copA VC_2300 VC_2300 VC_2334 VC_2334 VC_2339 VC_2339 VC_2356 VC_2356 VC_2442 VC_2442 VC_2522 VC_2522 VC_2534 VC_2534 kefB kefB VC_2690 VC_2690 nhaP2 nhaP2 VC_2756 VC_2756 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB sstT sstT gltS gltS VC_A0071 VC_A0071 VC_A0072 VC_A0072 pstB2 pstB2 VC_A0077 VC_A0077 VC_A0103 VC_A0103 VC_A0137 VC_A0137 VC_A0152 VC_A0152 VC_A0153 VC_A0153 VC_A0194 VC_A0194 VC_A0516 VC_A0516 clcA clcA kup kup mscL mscL VC_A0684 VC_A0684 fbpC fbpC VC_A0707 VC_A0707 modC modC VC_A0725 VC_A0725 VC_A0759 VC_A0759 VC_A0817 VC_A0817 VC_A0834 VC_A0834 VC_A0983 VC_A0983 VC_A1071 VC_A1071 VC_1437 VC_1437 VC_1422 VC_1422 VC_1261 VC_1261 VC_1033 VC_1033 VC_0988 VC_0988 cysZ cysZ oadG2 oadG2 VC_0784 VC_0784 VC_0770 VC_0770 pstB1 pstB1 VC_0725 VC_0725 VC_0676 VC_0676 VC_0610 VC_0610 VC_0587 VC_0587 VC_0574 VC_0574 VC_0573 VC_0573 oadG1 oadG1 cysA cysA VC_0540 VC_0540 VC_0539 VC_0539 VC_0480 VC_0480 VC_0389 VC_0389 VC_0302 VC_0302 VC_0300 VC_0300 VC_0265 VC_0265 sthA sthA crcB crcB VC_0043 VC_0043 VC_0042 VC_0042 VC_0022 VC_0022
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
VC_1442Cytochrome c oxidase, subunit CcoN; Similar to SP:P98059 PID:556813; identified by sequence similarity; putative; Belongs to the heme-copper respiratory oxidase family. (477 aa)
nhaANa+/H+ antiporter protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Contributes to the survival of V.cholerae during the stationary and exponential growth phases in a saline environment. (382 aa)
VC_1634Multidrug resistance protein; Similar to SP:P28246 GB:X63703 PID:41065 PID:424052 GB:U00096; identified by sequence similarity; putative. (401 aa)
VC_1653Sensory box sensor histidine kinase/response regulator VieS; Similar to GP:3123890; identified by sequence similarity; putative. (1146 aa)
VC_1655Magnesium transporter; Acts as a magnesium transporter. (451 aa)
VC_1751Conserved hypothetical protein; Identified by Glimmer2; putative. (292 aa)
VC_1821PTS system, fructose-specific IIBC component; Similar to SP:P32672 GB:U00006 PID:396296 GB:U00096 PID:1790386; identified by sequence similarity; putative. (467 aa)
VC_1822PTS system, fructose-specific IIABC component; Similar to GB:AL009126; identified by sequence similarity; putative. (621 aa)
VC_1826PTS system, fructose-specific IIABC component; Similar to GB:AL009126; identified by sequence similarity; putative. (633 aa)
VC_1863Amino acid ABC transporter, periplasmic amino acid-binding protein; Similar to PID:1166635 GB:U00096 PID:1788649 PID:1799691; identified by sequence similarity; putative; Belongs to the bacterial solute-binding protein 3 family. (260 aa)
nhaBNa+/H+ antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. (530 aa)
VC_2031Sulfate permease family protein; Similar to SP:P55189 PID:1256150 GB:AL009126; identified by sequence similarity; putative. (521 aa)
VC_2077Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (758 aa)
znuCZinc ABC transporter, ATP-binding protein; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (262 aa)
VC_2130Flagellum-specific ATP synthase FliI; Similar to PID:1071643 SP:P52612 GB:U00096 PID:1736607 PID:1788251; identified by sequence similarity; putative. (439 aa)
copACation transport ATPase, E1-E2 family; Involved in copper export. (915 aa)
VC_2300ampG protein, putative; Similar to GB:U00096 SP:P36670 PID:1773117 PID:1786636 PID:563855; identified by sequence similarity; putative. (462 aa)
VC_2334Conserved hypothetical protein; Identified by Glimmer2; putative. (327 aa)
VC_2339Chromate resistance protein-related protein; Similar to GB:S41232 GB:S41228; identified by sequence similarity; putative. (380 aa)
VC_2356Sodium/alanine symporter; Similar to SP:P30143 GB:U00096 PID:1786188; identified by sequence similarity; putative. (476 aa)
VC_2442Pho4 family protein; Similar to GB:L42023 SP:P45268 PID:1007859 PID:1221747 PID:1205836; identified by sequence similarity; putative. (433 aa)
VC_2522Conserved hypothetical protein; Identified by Glimmer2; putative. (332 aa)
VC_2534Magnesium transporter; Acts as a magnesium transporter. (453 aa)
kefBGlutathione-regulated potassium-efflux system protein KefB; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (656 aa)
VC_2690Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (302 aa)
nhaP2Conserved hypothetical protein; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (581 aa)
VC_2756Potassium uptake protein TrkH; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. (485 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (467 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (288 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (523 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa)
atpFATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (85 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (270 aa)
sstTSodium/dicarboxylate symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (405 aa)
gltSSodium/glutamate symporter; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. (408 aa)
VC_A0071Phosphate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (327 aa)
VC_A0072Phosphate ABC transporter, permease protein; Similar to GB:AE000783; identified by sequence similarity; putative. (289 aa)
pstB2Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (251 aa)
VC_A0077Sulfate permease family protein; Similar to GB:AL009126; identified by sequence similarity; putative. (553 aa)
VC_A0103Sulfate permease family protein; Similar to GB:AL123456; identified by sequence similarity; putative. (592 aa)
VC_A0137Glycerol-3-phosphate transporter; Similar to SP:P08194 GB:Y00536 PID:41587 GB:U00096 PID:1788573; identified by sequence similarity; putative. (469 aa)
VC_A0152Conserved hypothetical protein; Identified by Glimmer2; putative. (107 aa)
VC_A0153Conserved hypothetical protein; Identified by Glimmer2; putative. (103 aa)
VC_A0194Potassium channel protein, putative; Similar to PID:1089906; identified by sequence similarity; putative. (280 aa)
VC_A0516PTS system, fructose-specific IIBC component; Similar to SP:P20966 GB:M23196 PID:405893 PID:450372 GB:U00096; identified by sequence similarity; putative. (580 aa)
clcAConserved hypothetical protein; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. (468 aa)
kupPotassium uptake protein, Kup system; Transport of potassium into the cell; Belongs to the HAK/KUP transporter (TC 2.A.72) family. (620 aa)
mscLLarge-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (136 aa)
VC_A0684Regulatory protein UhpC; Similar to GB:L10328 SP:P09836 GB:M89479 PID:148114 PID:148119; identified by sequence similarity; putative. (436 aa)
fbpCiron(III) ABC transporter, ATP-binding protein; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (351 aa)
VC_A0707Regulatory protein UhpC, putative; Similar to GB:M89480 SP:P27669 GB:X52093 PID:154410; identified by sequence similarity; putative. (459 aa)
modCMolybdenum ABC transporter, ATP-binding protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (366 aa)
VC_A0725Molybdenum ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (232 aa)
VC_A0759Arginine ABC transporter, periplasmic arginine-binding protein; Similar to SP:P30859 GB:X67753 GB:X86160 PID:40931 PID:769791; identified by sequence similarity; putative; Belongs to the bacterial solute-binding protein 3 family. (243 aa)
VC_A0817Hypothetical protein; Identified by Glimmer2; putative. (194 aa)
VC_A0834Hypothetical protein; Identified by Glimmer2; putative. (317 aa)
VC_A0983L-lactate permease, putative; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (582 aa)
VC_A1071Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (496 aa)
VC_1437Cation transport ATPase, E1-E2 family; Similar to PID:1200219; identified by sequence similarity; putative. (790 aa)
VC_1422Sodium/alanine symporter; Similar to GB:L42023 SP:P44917 PID:1005967 PID:1220986 PID:1205130; identified by sequence similarity; putative. (458 aa)
VC_1261Conserved hypothetical protein; Identified by Glimmer2; putative. (404 aa)
VC_1033Cation transport ATPase, E1-E2 family; Similar to SP:P37617 PID:466605 GB:U00096 PID:1789879; identified by sequence similarity; putative. (768 aa)
VC_0988Proton/peptide symporter family protein; Similar to GB:U00096 PID:1742700 PID:1787922; identified by sequence similarity; putative. (514 aa)
cysZcysZ protein; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (250 aa)
oadG2Hypothetical protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (139 aa)
VC_0784Sodium/alanine symporter; Similar to GB:AL009126; identified by sequence similarity; putative. (516 aa)
VC_0770Conserved hypothetical protein; Identified by Glimmer2; putative. (197 aa)
pstB1Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (273 aa)
VC_0725Phosphate ABC transporter, permease protein; Similar to PID:633994 PID:1369911; identified by sequence similarity; putative. (548 aa)
VC_0676nptA protein; Similar to GP:3646477; identified by sequence similarity; putative. (382 aa)
VC_0610iron(III) ABC transporter, ATP-binding protein; Similar to PID:1653298; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (343 aa)
VC_0587Sulfate permease family protein; Similar to PID:1001216 PID:1001268; identified by sequence similarity; putative. (548 aa)
VC_0574Ubiquinol--cytochrome c reductase, cytochrome B; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (421 aa)
VC_0573Ubiquinol--cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (197 aa)
oadG1Hypothetical protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (117 aa)
cysASulfate ABC transporter, ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (376 aa)
VC_0540Sulfate ABC transporter, permease protein; Similar to GB:M32101 SP:P16702 PID:145660 GB:U00096 PID:1788762; identified by sequence similarity; putative. (287 aa)
VC_0539Sulfate ABC transporter, permease protein; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (283 aa)
VC_0480Conserved hypothetical protein; Identified by Glimmer2; putative. (287 aa)
VC_0389Na+/H+ antiporter, putative; Similar to GP:3327262; identified by sequence similarity; putative. (444 aa)
VC_0302Conserved hypothetical protein; Identified by Glimmer2; putative. (396 aa)
VC_0300Conserved hypothetical protein; Identified by Glimmer2; putative. (607 aa)
VC_0265Conserved hypothetical protein; Identified by Glimmer2; putative. (412 aa)
sthAPyridine nucleotide-disulfide oxidoreductase, class I; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
crcBcrcB protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (126 aa)
VC_0043Potassium uptake protein TrkA; Similar to GB:D28477 SP:P39448 PID:541661; identified by sequence similarity; putative. (458 aa)
VC_0042Potassium uptake protein TrkH; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. (481 aa)
VC_0022Conserved hypothetical protein; Identified by Glimmer2; putative. (200 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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