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| | groL2 | Chaperonin, 60 Kd subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (530 aa) |
| | gyrB | DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa) |
| | VC_0050 | DNA topoisomerase I-related protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677; identified by sequence similarity; putative. (190 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (290 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (265 aa) |
| | hldD | ADP-L-glycero-D-mannoheptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. (314 aa) |
| | rfbB | Phosphomannomutase; Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides; Belongs to the phosphohexose mutase family. (463 aa) |
| | VC_0269 | Mannose-6-phosphate isomerase; Similar to SP:P25081 GB:X57117 PID:48820; identified by sequence similarity; putative; Belongs to the mannose-6-phosphate isomerase type 1 family. (399 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa) |
| | VC_0354 | Peptidyl-prolyl cis-trans isomerase, FKBP-type; Similar to SP:P45523 SP:P39175 PID:606281 PID:862300 GB:U00096; identified by sequence similarity; putative. (259 aa) |
| | alr1 | Alanine racemase, biosynthetic; Catalyzes the interconversion of L-alanine and D-alanine. Likely plays an important role in supplying D-alanine, which is an indispensable constituent in the biosynthesis of bacterial cell-wall peptidoglycan. To a lesser extent, is also able to racemize L-serine and D-serine. Does not act on other proteinogenic amino-acids. (375 aa) |
| | pgi | Glucose-6-phosphate isomerase; Similar to SP:P11537 GB:X15196 PID:396360 PID:42377 GB:U00096; identified by sequence similarity; putative. (550 aa) |
| | surA | Survival protein SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (431 aa) |
| | truD | Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (361 aa) |
| | gmhA | Phosphoheptose isomerase, putative; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (196 aa) |
| | VC_0611 | Similar to GB:AE000657; identified by sequence similarity; putative. (470 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase; Similar to GB:D26562 SP:P23893 GB:X53696 PID:41621 PID:473813; identified by sequence similarity; putative. (432 aa) |
| | glmM | Phosphoglucomutase/phosphomannomutase family protein MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (446 aa) |
| | truB | tRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (312 aa) |
| | VC_0684 | Peptidyl-prolyl cis-trans isomerase, FKBP-type; Similar to GB:D10483 SP:P22563 GB:X54945 PID:216455 PID:41932; identified by sequence similarity; putative. (144 aa) |
| | VC_0696 | Chorismate mutase/prephenate dehydrogenase; Similar to SP:Q02287 GB:M74135 GB:X60420 PID:415010 PID:43345; identified by sequence similarity; putative. (375 aa) |
| | VC_0705 | Chorismate mutase/prephenate dehydratase; Similar to GB:L42023 SP:P43900 PID:1006481 PID:1221267 PID:1205390; identified by sequence similarity; putative. (391 aa) |
| | rluD | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RluA family. (324 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (352 aa) |
| | vibC | Vibriobactin-specific isochorismate synthase; Similar to PID:2182763; identified by sequence similarity; putative; Belongs to the isochorismate synthase family. (395 aa) |
| | truC | Pseudouridine synthase Rlu family protein; Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs; Belongs to the pseudouridine synthase RluA family. (244 aa) |
| | VC_0917 | UDP-N-acetylglucosamine 2-epimerase; Similar to GB:M87049 SP:P27828 GB:L18799 PID:148189 PID:304919; identified by sequence similarity; putative; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (372 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (264 aa) |
| | fadJ | Fatty oxidation complex, alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (724 aa) |
| | VC_1124 | Conserved hypothetical protein; Identified by Glimmer2; putative. (188 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Similar to GB:L42023 SP:P44435 PID:1003830 PID:1222407 PID:1204723; identified by sequence similarity; putative. (245 aa) |
| | rluE | Pseudouridine synthase family 1 protein; Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family. (290 aa) |
| | trpCF | Indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). (469 aa) |
| | VC_A1041 | Phosphomannomutase, putative; Similar to GB:AE000520; identified by sequence similarity; putative. (567 aa) |
| | rluB | Pseudouridine synthase family 1 protein; Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family. (321 aa) |
| | gyrA | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (894 aa) |
| | bsrV | Alanine racemase, putative; Amino-acid racemase able to utilize a broad range of substrates. Reversibly racemizes ten of the 19 natural chiral amino acids known, including both non-beta-branched aliphatic amino acids (Ala, Leu, Met, Ser, Cys, Gln and Asn) and positively charged amino acids (His, Lys and Arg). Among these substrates, is the most efficient with lysine and arginine. Is also able to catalyze the racemization of several amino acids that are not typically incorporated into proteins such as ornithine and norleucine. Is not active on negatively charged (Glu and Asp) or aromati [...] (428 aa) |
| | VC_1339 | Conserved hypothetical protein; Identified by Glimmer2; putative. (400 aa) |
| | maiA | Glutathione S-transferase, putative; Similar to PID:2183249; identified by sequence similarity; putative; Belongs to the GST superfamily. Zeta family. (215 aa) |
| | VC_1454 | RstA1 protein; Similar to GP:2564352; identified by sequence similarity; putative. (359 aa) |
| | fabA | 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity). (172 aa) |
| | VC_1594 | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (350 aa) |
| | rsuA | Ribosomal small subunit pseudouridine synthase A; Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family. (231 aa) |
| | VC_1668 | Pseudouridine synthase Rlu family protein; Similar to GB:L42023 SP:P43930 PID:1004184 PID:1221947 PID:1204300; identified by sequence similarity; putative. (235 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (876 aa) |
| | nanM | Conserved hypothetical protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. (384 aa) |
| | nanE | Conserved hypothetical protein; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (240 aa) |
| | VC_1827 | Mannose-6-phosphate isomerase; Similar to GB:M15380 SP:P00946 PID:146722 GB:U00096 PID:1742663; identified by sequence similarity; putative; Belongs to the mannose-6-phosphate isomerase type 1 family. (388 aa) |
| | VC_1849 | Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa) |
| | VC_1918 | Peptidyl-prolyl cis-trans isomerse D; Similar to GB:U00096 SP:P77241 PID:1580712 PID:1773125 PID:1786645; identified by sequence similarity; putative. (619 aa) |
| | tig | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). Belongs to the FKBP-type PPIase family. Tig subfamily. (433 aa) |
| | menF | Menaquinone-specific isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. (435 aa) |
| | VC_2001 | Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the glucose-6-phosphate 1-epimerase family. (296 aa) |
| | rluC | Ribosomal large subunit pseudouridine synthase C; Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RluA family. (315 aa) |
| | topB | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (647 aa) |
| | VC_2095 | Phosphoglucomutase; Similar to SP:P36938 GB:U08369 PID:473888 GB:U00096 PID:1651293; identified by sequence similarity; putative. (548 aa) |
| | VC_2223 | Pseudouridine synthase family 1 protein; Similar to SP:P32684 PID:396357 GB:U00096 PID:1790453; identified by sequence similarity; putative; Belongs to the pseudouridine synthase RsuA family. (340 aa) |
| | gmhA-2 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (191 aa) |
| | VC_2299 | Peptidyl-prolyl cis-trans isomerase A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (194 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (406 aa) |
| | parC | Topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (761 aa) |
| | parE | Topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (626 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (218 aa) |
| | rluA | Ribosomal large subunit pseudouridine synthase A; Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs. (245 aa) |
| | VC_2523 | Conserved hypothetical protein; Identified by Glimmer2; putative. (326 aa) |
| | VC_A0953 | Peptidyl-prolyl cis-trans isomerase C; Similar to SP:P39159 PID:836657 PID:693800 GB:U00096 PID:1790211; identified by sequence similarity; putative. (92 aa) |
| | VC_2568 | Peptidyl-prolyl cis-trans isomerase, FKBP-type; Similar to GB:U14003 SP:P39311 PID:537048 GB:U00096 PID:1790652; identified by sequence similarity; putative. (209 aa) |
| | slyD | Peptidyl-prolyl cis-trans isomerase, FKBP-type; Folding helper with both chaperone and peptidyl-prolyl cis- trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa- Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction; Belongs to the FKBP-type PPIase family. (201 aa) |
| | VC_2625 | Ribulose-phosphate 3-epimerase; Similar to SP:P32661 GB:Z19601 PID:41222 GB:U00096 PID:1789788; identified by sequence similarity; putative; Belongs to the ribulose-phosphate 3-epimerase family. (236 aa) |
| | groL1 | Chaperonin, 60 Kd subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa) |
| | VC_2669 | 5-carboxymethyl-2-hydroxymuconate delta isomerase, putative; Similar to GB:X53666 GB:Z37980 SP:Q05354 PID:41106 PID:757829; identified by sequence similarity; putative. (116 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (265 aa) |
| | fadB | Fatty oxidation complex, alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (723 aa) |
| | VC_A0104 | Ribosomal large subunit pseudouridine synthase A; Similar to SP:P39219 GB:U00096 PID:1786244; identified by sequence similarity; putative. (221 aa) |
| | rbsD | Ribose ABC transporter protein; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. (156 aa) |
| | nnr | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). In the N-terminal section; belongs to the NnrE/AIBP family. (494 aa) |
| | VC_A0241 | Hexulose-6-phosphate isomerase SgbU, putative; Similar to GB:L42023 SP:P44990 PID:1006252 PID:1221141 PID:1205275; identified by sequence similarity; putative. (294 aa) |
| | VC_A0244 | Sugar isomerase SgaE, AraD/FucA family; Similar to GB:L42023 SP:P44989 PID:1006250 PID:1221140 PID:1205274; identified by sequence similarity; putative. (230 aa) |
| | VC_A0395 | Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the PhzF family. (279 aa) |
| | nagB | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa) |
| | VC_A0496 | Glutathione S-transferase, putative; Similar to SP:P28342 PID:167968 PID:18330; identified by sequence similarity; putative. (226 aa) |
| | VC_A0552 | Fatty acid cis/trans isomerase; Similar to GP:2612821; identified by sequence similarity; putative. (766 aa) |
| | VC_A0661 | Peptidyl-prolyl cis-trans isomerase-related protein; Similar to GB:U14003 SP:P39311 PID:537048 GB:U00096 PID:1790652; identified by sequence similarity; putative. (157 aa) |
| | VC_A0662 | CbbY family protein; Similar to GB:U00096 PID:1789046; identified by sequence similarity; putative. (212 aa) |
| | VC_A0774 | UDP-glucose 4-epimerase; Similar to SP:P09147 GB:V00278 GB:X06226 GB:X51449 PID:41523; identified by sequence similarity; putative; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (338 aa) |
