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VC_2087 VC_2087 VC_A1063 VC_A1063 VC_A0949 VC_A0949 VC_0019 VC_0019 ilvA ilvA VC_0031 VC_0031 lysA lysA VC_0244 VC_0244 alr1 alr1 metH metH VC_0461 VC_0461 hemL hemL iscS iscS VC_0775 VC_0775 dxs dxs glyA1 glyA1 bioA bioA bioF bioF hisC hisC VC_1149 VC_1149 serC serC VC_1293 VC_1293 bsrV bsrV VC_1590 VC_1590 nspC nspC VC_1671 VC_1671 menD menD VC_1977 VC_1977 pabC pabC csd csd VC_2362 VC_2362 btuF btuF VC_2472 VC_2472 VC_2483 VC_2483 VC_2539 VC_2539 argD argD VC_2683 VC_2683 VC_A0013 VC_A0013 VC_A0269 VC_A0269 glyA2 glyA2 VC_A0513 VC_A0513 cqsA cqsA VC_A0530 VC_A0530 VC_A0605 VC_A0605 ectB ectB VC_A0871 VC_A0871 dsdA dsdA kbl kbl VC_A0924 VC_A0924
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
VC_20872-oxoglutarate dehydrogenase, E1 component; Similar to GB:J01619 SP:P07015 PID:146201 PID:43019 GB:U00096; identified by sequence similarity; putative. (936 aa)
VC_A1063Ornithine decarboxylase, inducible; Similar to GB:M64495 SP:P24169 PID:147331 GB:U00096 PID:1651300; identified by sequence similarity; putative. (720 aa)
VC_A0949SM-20-related protein; Similar to GP:469478; identified by sequence similarity; putative. (205 aa)
VC_0019Valine-pyruvate aminotransferase; Similar to SP:P09053 PID:466710 GB:U00096 PID:1789996; identified by sequence similarity; putative. (418 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (510 aa)
VC_0031Acetolactate synthase II, large subunit; Similar to SP:P00892; identified by sequence similarity; putative. (548 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (417 aa)
VC_0244Perosamine synthase; Similar to GB:X59554 PID:48386; identified by sequence similarity; putative; Belongs to the DegT/DnrJ/EryC1 family. (367 aa)
alr1Alanine racemase, biosynthetic; Catalyzes the interconversion of L-alanine and D-alanine. Likely plays an important role in supplying D-alanine, which is an indispensable constituent in the biosynthesis of bacterial cell-wall peptidoglycan. To a lesser extent, is also able to racemize L-serine and D-serine. Does not act on other proteinogenic amino-acids. (375 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1226 aa)
VC_0461Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (236 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase; Similar to GB:D26562 SP:P23893 GB:X53696 PID:41621 PID:473813; identified by sequence similarity; putative. (432 aa)
iscSAminotransferase NifS, class V; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (404 aa)
VC_0775Vibriobactin synthesis protein, putative; Similar to GB:M60177 SP:P11454 GB:M17354 PID:145843 PID:551801; identified by sequence similarity; putative. (438 aa)
dxs1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (626 aa)
glyA1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (435 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (428 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa)
hisCHistidinol-phosphate aminotransferase; Similar to SP:P06986 GB:U02071 GB:X03416 PID:41695 PID:41710; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (346 aa)
VC_1149Glutamate decarboxylase, putative; Similar to SP:Q05683 PID:204226; identified by sequence similarity; putative. (548 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (379 aa)
VC_1293Aspartate aminotransferase; Similar to SP:P00509 GB:X03629 GB:X05904 PID:41011 PID:41013; identified by sequence similarity; putative. (413 aa)
bsrVAlanine racemase, putative; Amino-acid racemase able to utilize a broad range of substrates. Reversibly racemizes ten of the 19 natural chiral amino acids known, including both non-beta-branched aliphatic amino acids (Ala, Leu, Met, Ser, Cys, Gln and Asn) and positively charged amino acids (His, Lys and Arg). Among these substrates, is the most efficient with lysine and arginine. Is also able to catalyze the racemization of several amino acids that are not typically incorporated into proteins such as ornithine and norleucine. Is not active on negatively charged (Glu and Asp) or aromati [...] (428 aa)
VC_1590Acetolactate synthase; Similar to GB:M73842 SP:P27696 GB:Y00525 PID:149211; identified by sequence similarity; putative; Belongs to the TPP enzyme family. (567 aa)
nspCCarboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine. Essential for biofilm formation. (387 aa)
VC_1671Cystathionine beta-lyase; Similar to GB:M12858 SP:P06721 PID:146824 PID:882537 PID:1789383; identified by sequence similarity; putative. (396 aa)
menD2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (570 aa)
VC_1977Aspartate aminotransferase, putative; Similar to GB:U00096 PID:1788627 PID:1799660; identified by sequence similarity; putative. (404 aa)
pabC4-amino-4-deoxychorismate lyase; Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity). (277 aa)
csdAminotransferase, class V; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (404 aa)
VC_2362Threonine synthase; Similar to GB:L42023 SP:P44503 PID:1003078 PID:1221997 PID:1204345; identified by sequence similarity; putative. (426 aa)
btuFConserved hypothetical protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. (276 aa)
VC_2472Conserved hypothetical protein; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. (323 aa)
VC_2483Acetolactate synthase III, large subunit; Similar to GB:D10483 SP:P00893 GB:X01609 PID:216494 PID:40845; identified by sequence similarity; putative. (573 aa)
VC_2539Thiamin ABC transporter, periplasmic thiamin-binding protein; Similar to GB:D10483 SP:P31550 GB:U09984 PID:216488 PID:497658; identified by sequence similarity; putative. (330 aa)
argDAcetylornithine aminotransferase; Similar to GB:M32796 SP:P18335 PID:145337 PID:606293 GB:U00096; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa)
VC_2683Cystathionine gamma-synthase; Similar to GB:L19201 SP:P00935 PID:146846 PID:305042 GB:U00096; identified by sequence similarity; putative. (388 aa)
VC_A0013Maltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (817 aa)
VC_A0269Decarboxylase, group II; Similar to GB:L42023 PID:1161418 PID:1221055 PID:1205195 PID:1573971; identified by sequence similarity; putative. (557 aa)
glyA2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (435 aa)
VC_A0513Amino acid biosynthesis aminotransferase; Similar to PID:1806263; identified by sequence similarity; putative. (404 aa)
cqsAAminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (389 aa)
VC_A0530Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. (1079 aa)
VC_A0605Aminotransferase, class III; Similar to GB:Pyro_h; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (465 aa)
ectBDiaminobutyrate--pyruvate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (411 aa)
VC_A0871Transcriptional regulator, GntR family; Similar to GB:U00096 PID:1742348 PID:1742355 PID:1787710; identified by sequence similarity; putative. (473 aa)
dsdAD-serine dehydratase; Similar to GB:J01603 SP:P00926 GB:X86379 PID:145806 GB:U00096; identified by sequence similarity; putative; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (441 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
VC_A0924Conserved hypothetical protein; Identified by Glimmer2; putative. (662 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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