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VC_2426 VC_2426 rsmH rsmH rlmG rlmG cheR1 cheR1 VC_0876 VC_0876 tcpJ tcpJ VC_0803 VC_0803 rlmN rlmN trmJ trmJ thyA thyA VC_0661 VC_0661 rlmE rlmE rsmC rsmC rsmI rsmI trmD trmD pcm pcm VC_0469 VC_0469 trmB trmB rsmA rsmA metH metH prmA prmA rlmJ rlmJ trmA trmA VC_0146 VC_0146 VC_0118 VC_0118 VC_0113 VC_0113 VC_0091 VC_0091 ubiE ubiE rsmJ rsmJ rsmB rsmB mnmE mnmE rlmH rlmH VC_1065 VC_1065 bioC bioC cmoB cmoB tpm tpm ubiG ubiG rlmI rlmI cheR2 cheR2 rlmL rlmL rsmF rsmF rlmF rlmF metE metE cmoM cmoM VC_1769 VC_1769 VC_2003 VC_2003 mnmC mnmC prmB prmB prmC prmC cheR3 cheR3 VC_A1059 VC_A1059 VC_A1018 VC_A1018 VC_A1017 VC_A1017 rlmC rlmC VC_A0832 VC_A0832 VC_A0634 VC_A0634 VC_A0627 VC_A0627 VC_A0447 VC_A0447 VC_A0198 VC_A0198 mnmG mnmG rsmG rsmG trmL trmL dam dam rlmB rlmB VC_2561 VC_2561 rlmD rlmD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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VC_2426Leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (291 aa)
rsmHConserved hypothetical protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (316 aa)
rlmGConserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (416 aa)
cheR1Chemotaxis protein methyltransferase CheR; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (275 aa)
VC_0876Conserved hypothetical protein; Identified by Glimmer2; putative. (231 aa)
tcpJLeader peptidase TcpJ; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the TcpA pilin precursor during membrane translocation. (253 aa)
VC_0803RNA methyltransferase, TrmH family; Similar to GB:AL009126; identified by sequence similarity; putative. (257 aa)
rlmNConserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (373 aa)
trmJRNA methyltransferase, TrmH family; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (244 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (283 aa)
VC_0661Conserved hypothetical protein; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC). (240 aa)
rlmECell division protein FtsJ; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (209 aa)
rsmCConserved hypothetical protein; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family. (340 aa)
rsmIConserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (288 aa)
trmDtRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (247 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (208 aa)
VC_0469Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (243 aa)
trmBConserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (239 aa)
rsmADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (282 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1226 aa)
prmARibosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (295 aa)
rlmJConserved hypothetical protein; Specifically methylates the adenine in position 2030 of 23S rRNA. (279 aa)
trmAtRNA (uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (369 aa)
VC_0146Conserved hypothetical protein; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (199 aa)
VC_0118uroporphyrin-III C-methyltransferase, putative; Similar to GB:M87049 SP:P09127 GB:X12614 GB:X13406 PID:148202; identified by sequence similarity; putative. (399 aa)
VC_0113Methyltransferase-related protein; Similar to SP:P37431 PID:295895; identified by sequence similarity; putative. (222 aa)
VC_0091O-methyltransferase-related protein; Similar to GB:M80674 SP:P39887 PID:153491; identified by sequence similarity; putative. (289 aa)
ubiEUbiquinone/menaquinone biosynthesis methlytransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (260 aa)
rsmJConserved hypothetical protein; Specifically methylates the guanosine in position 1516 of 16S rRNA. (292 aa)
rsmBSun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (434 aa)
mnmEThiophene and furan oxidation protein ThdF; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (464 aa)
rlmHConserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (156 aa)
VC_1065methylated-DNA--protein-cysteine methyltransferase-related protein; Similar to GB:U00096 SP:P75707 PID:1786659; identified by sequence similarity; putative. (100 aa)
bioCBiotin synthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (312 aa)
cmoBConserved hypothetical protein; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. (323 aa)
tpmThiopurine methyltransferase; Similar to SP:O86262; identified by sequence similarity; putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. (218 aa)
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (245 aa)
rlmIConserved hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. (418 aa)
cheR2Chemotaxis protein methyltransferase CheR; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (288 aa)
rlmLConserved hypothetical protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (708 aa)
rsmFSun/nucleolar protein family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. (503 aa)
rlmFConserved hypothetical protein; Specifically methylates the adenine in position 1618 of 23S rRNA. (362 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (761 aa)
cmoMsmtA protein; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family. (260 aa)
VC_1769DNA methylase HsdM, putative; Similar to GB:AL123456; identified by sequence similarity; putative. (793 aa)
VC_2003rRNA (guanine-N1-)-methyltransferase; Similar to GB:D28496 SP:P36999 PID:460699 GB:U00096 PID:1736466; identified by sequence similarity; putative. (278 aa)
mnmCConserved hypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. (674 aa)
prmBAdenine-specific methylase, putative; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (314 aa)
prmChemK protein; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (286 aa)
cheR3Chemotaxis protein methyltransferase CheR; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (276 aa)
VC_A1059Conserved hypothetical protein; Identified by Glimmer2; putative. (205 aa)
VC_A1018Ada regulatory protein; Similar to SP:Q10630 PID:1340083 PID:1513196 GB:AL123456; identified by sequence similarity; putative. (452 aa)
VC_A1017methylated-DNA--protein-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (157 aa)
rlmCTrmA family RNA methyltransferase, putative; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. (375 aa)
VC_A0832Methyltransferase, putative; Similar to SP:P37431 PID:295895; identified by sequence similarity; putative. (210 aa)
VC_A0634Conserved hypothetical protein; Identified by Glimmer2; putative. (241 aa)
VC_A0627rRNA methylase, putative; Similar to GP:3328978; identified by sequence similarity; putative. (170 aa)
VC_A0447Haemagglutinin associated protein; Similar to GB:X64387 PID:396849 PID:48357; identified by sequence similarity; putative; Belongs to the N(4)/N(6)-methyltransferase family. (230 aa)
VC_A0198Site-specific DNA-methyltransferase, putative; Similar to SP:P34906; identified by sequence similarity; putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (383 aa)
mnmGGlucose inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (631 aa)
rsmGGlucose inhibited division protein B; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (210 aa)
trmLrRNA methylase, SpoU family; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (158 aa)
damDNA adenine methylase; Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair; Belongs to the N(4)/N(6)-methyltransferase family. (277 aa)
rlmBRNA methyltransferase, TrmH family; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (247 aa)
VC_2561uroporphyrin-III C-methyltransferase; Similar to SP:P11098 GB:X14202 PID:581142 PID:606302 GB:U00096; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. (299 aa)
rlmDTrmA family RNA methyltransferase, putative; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (440 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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