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VC_1544 VC_1544 VC_1437 VC_1437 VC_A0153 VC_A0153 VC_A0152 VC_A0152 VC_A0064 VC_A0064 gltS gltS sstT sstT atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC VC_2756 VC_2756 nhaP2 nhaP2 VC_2690 VC_2690 VC_0573 VC_0573 oadG1 oadG1 irgA irgA VC_0389 VC_0389 VC_0302 VC_0302 VC_0300 VC_0300 VC_0200 VC_0200 sthA sthA VC_0043 VC_0043 VC_0042 VC_0042 VC_0574 VC_0574 VC_0610 VC_0610 VC_0676 VC_0676 VC_0770 VC_0770 VC_0784 VC_0784 oadG2 oadG2 cysZ cysZ VC_0988 VC_0988 VC_1033 VC_1033 VC_1261 VC_1261 VC_1422 VC_1422 kefB kefB VC_2534 VC_2534 VC_2522 VC_2522 VC_2356 VC_2356 VC_2334 VC_2334 VC_2300 VC_2300 copA copA viuA viuA VC_2130 VC_2130 znuC znuC VC_2077 VC_2077 ccmA ccmA VC_2012 VC_2012 nhaB nhaB VC_1826 VC_1826 VC_1822 VC_1822 VC_1821 VC_1821 VC_1655 VC_1655 VC_1634 VC_1634 nhaA nhaA VC_1581 VC_1581 VC_1442 VC_1442 VC_A1071 VC_A1071 VC_A0983 VC_A0983 tonB tonB VC_A0834 VC_A0834 fbpC fbpC VC_A0625 VC_A0625 VC_A0576 VC_A0576 VC_A0563 VC_A0563 kup kup VC_A0516 VC_A0516 VC_A0194 VC_A0194
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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VC_1544tonB2 protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (206 aa)
VC_1437Cation transport ATPase, E1-E2 family; Similar to PID:1200219; identified by sequence similarity; putative. (790 aa)
VC_A0153Conserved hypothetical protein; Identified by Glimmer2; putative. (103 aa)
VC_A0152Conserved hypothetical protein; Identified by Glimmer2; putative. (107 aa)
VC_A0064TonB system receptor, putative; Similar to GB:L27149 PID:529727; identified by sequence similarity; putative. (713 aa)
gltSSodium/glutamate symporter; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. (408 aa)
sstTSodium/dicarboxylate symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (405 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (270 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (85 aa)
atpFATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (523 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (288 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (467 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa)
VC_2756Potassium uptake protein TrkH; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. (485 aa)
nhaP2Conserved hypothetical protein; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (581 aa)
VC_2690Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (302 aa)
VC_0573Ubiquinol--cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (197 aa)
oadG1Hypothetical protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (117 aa)
irgAIron-regulated outer membrane virulence protein, TonB receptor family; Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment; Belongs to the TonB-dependent receptor family. (652 aa)
VC_0389Na+/H+ antiporter, putative; Similar to GP:3327262; identified by sequence similarity; putative. (444 aa)
VC_0302Conserved hypothetical protein; Identified by Glimmer2; putative. (396 aa)
VC_0300Conserved hypothetical protein; Identified by Glimmer2; putative. (607 aa)
VC_0200iron(III) compound receptor; Similar to GB:D26562 SP:P06971 GB:M12486 PID:145949 PID:473809; identified by sequence similarity; putative. (718 aa)
sthAPyridine nucleotide-disulfide oxidoreductase, class I; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
VC_0043Potassium uptake protein TrkA; Similar to GB:D28477 SP:P39448 PID:541661; identified by sequence similarity; putative. (458 aa)
VC_0042Potassium uptake protein TrkH; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. (481 aa)
VC_0574Ubiquinol--cytochrome c reductase, cytochrome B; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (421 aa)
VC_0610iron(III) ABC transporter, ATP-binding protein; Similar to PID:1653298; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (343 aa)
VC_0676nptA protein; Similar to GP:3646477; identified by sequence similarity; putative. (382 aa)
VC_0770Conserved hypothetical protein; Identified by Glimmer2; putative. (197 aa)
VC_0784Sodium/alanine symporter; Similar to GB:AL009126; identified by sequence similarity; putative. (516 aa)
oadG2Hypothetical protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (139 aa)
cysZcysZ protein; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (250 aa)
VC_0988Proton/peptide symporter family protein; Similar to GB:U00096 PID:1742700 PID:1787922; identified by sequence similarity; putative. (514 aa)
VC_1033Cation transport ATPase, E1-E2 family; Similar to SP:P37617 PID:466605 GB:U00096 PID:1789879; identified by sequence similarity; putative. (768 aa)
VC_1261Conserved hypothetical protein; Identified by Glimmer2; putative. (404 aa)
VC_1422Sodium/alanine symporter; Similar to GB:L42023 SP:P44917 PID:1005967 PID:1220986 PID:1205130; identified by sequence similarity; putative. (458 aa)
kefBGlutathione-regulated potassium-efflux system protein KefB; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (656 aa)
VC_2534Magnesium transporter; Acts as a magnesium transporter. (453 aa)
VC_2522Conserved hypothetical protein; Identified by Glimmer2; putative. (332 aa)
VC_2356Sodium/alanine symporter; Similar to SP:P30143 GB:U00096 PID:1786188; identified by sequence similarity; putative. (476 aa)
VC_2334Conserved hypothetical protein; Identified by Glimmer2; putative. (327 aa)
VC_2300ampG protein, putative; Similar to GB:U00096 SP:P36670 PID:1773117 PID:1786636 PID:563855; identified by sequence similarity; putative. (462 aa)
copACation transport ATPase, E1-E2 family; Involved in copper export. (915 aa)
viuAFerric vibriobactin receptor; Receptor for ferric vibriobactin; Belongs to the TonB-dependent receptor family. (687 aa)
VC_2130Flagellum-specific ATP synthase FliI; Similar to PID:1071643 SP:P52612 GB:U00096 PID:1736607 PID:1788251; identified by sequence similarity; putative. (439 aa)
znuCZinc ABC transporter, ATP-binding protein; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (262 aa)
VC_2077Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (758 aa)
ccmAHeme exporter protein A; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (207 aa)
VC_2012Sodium-dependent transporter; Similar to GB:AE000782; identified by sequence similarity; putative; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (527 aa)
nhaBNa+/H+ antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. (530 aa)
VC_1826PTS system, fructose-specific IIABC component; Similar to GB:AL009126; identified by sequence similarity; putative. (633 aa)
VC_1822PTS system, fructose-specific IIABC component; Similar to GB:AL009126; identified by sequence similarity; putative. (621 aa)
VC_1821PTS system, fructose-specific IIBC component; Similar to SP:P32672 GB:U00006 PID:396296 GB:U00096 PID:1790386; identified by sequence similarity; putative. (467 aa)
VC_1655Magnesium transporter; Acts as a magnesium transporter. (451 aa)
VC_1634Multidrug resistance protein; Similar to SP:P28246 GB:X63703 PID:41065 PID:424052 GB:U00096; identified by sequence similarity; putative. (401 aa)
nhaANa+/H+ antiporter protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Contributes to the survival of V.cholerae during the stationary and exponential growth phases in a saline environment. (382 aa)
VC_1581NADH dehydrogenase, putative; Similar to SP:P33607 PID:397909 GB:U00096 PID:1788614 PID:1799638; identified by sequence similarity; putative. (516 aa)
VC_1442Cytochrome c oxidase, subunit CcoN; Similar to SP:P98059 PID:556813; identified by sequence similarity; putative; Belongs to the heme-copper respiratory oxidase family. (477 aa)
VC_A1071Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (496 aa)
VC_A0983L-lactate permease, putative; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (582 aa)
tonBtonB1 protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity). (249 aa)
VC_A0834Hypothetical protein; Identified by Glimmer2; putative. (317 aa)
fbpCiron(III) ABC transporter, ATP-binding protein; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (351 aa)
VC_A0625TonB receptor-related protein; Similar to PID:1638846; identified by sequence similarity; putative. (784 aa)
VC_A0576Heme transport protein HutA; Similar to GB:L27149 PID:529727; identified by sequence similarity; putative. (698 aa)
VC_A0563NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (512 aa)
kupPotassium uptake protein, Kup system; Transport of potassium into the cell; Belongs to the HAK/KUP transporter (TC 2.A.72) family. (620 aa)
VC_A0516PTS system, fructose-specific IIBC component; Similar to SP:P20966 GB:M23196 PID:405893 PID:450372 GB:U00096; identified by sequence similarity; putative. (580 aa)
VC_A0194Potassium channel protein, putative; Similar to PID:1089906; identified by sequence similarity; putative. (280 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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