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VC_2133 VC_2133 fliE fliE fliD fliD flaD flaD flaE flaE flaA flaA flgI flgI flgH flgH VC_2195 VC_2195 VC_2196 VC_2196 VC_2197 VC_2197 VC_2199 VC_2199 VC_2200 VC_2200 dnaQ dnaQ rpsB rpsB VC_2303 VC_2303 csd csd VC_2340 VC_2340 VC_2341 VC_2341 recO recO VC_2497 VC_2497 VC_2502 VC_2502 rplQ rplQ rpsD rpsD rpsK rpsK rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ priA priA rpmE rpmE dtd dtd parB parB VC_A0042 VC_A0042 VC_A0061 VC_A0061 VC_A0168 VC_A0168 VC_A0169 VC_A0169 VC_A0170 VC_A0170 VC_A0172 VC_A0172 VC_A0189 VC_A0189 rhlE rhlE VC_A0283 VC_A0283 rpmI rpmI VC_A0405 VC_A0405 VC_A0447 VC_A0447 VC_A0490 VC_A0490 VC_A0593 VC_A0593 VC_A0681 VC_A0681 VC_A0735 VC_A0735 deaD deaD VC_A0832 VC_A0832 VC_A0840 VC_A0840 VC_A0895 VC_A0895 VC_A0994 VC_A0994 VC_A1107 VC_A1107 VC_A1106 VC_A1106 rpmH rpmH dnaA dnaA recF recF VC_0050 VC_0050 VC_0097 VC_0097 rep rep VC_0175 VC_0175 VC_0196 VC_0196 slmA slmA VC_0217 VC_0217 rpmB rpmB rpmG rpmG kdkA kdkA hupA hupA edd edd fis fis rplK rplK rplA rplA rplJ rplJ rplL rplL rpsG rpsG rpsF rpsF priB priB rpsR rpsR rplI rplI VC_0371 VC_0371 VC_0404 VC_0404 VC_0415 VC_0415 rplU rplU rpmA rpmA VC_0510 VC_0510 rpsU rpsU VC_A1114 VC_A1114 rpsP rpsP rplM rplM rpsI rpsI VC_0577 VC_0577 VC_0608 VC_0608 infB infB rpsO rpsO srmB srmB VC_0676 VC_0676 rpsT rpsT VC_0706 VC_0706 rdgC rdgC cutC cutC guaB guaB VC_0811 VC_0811 VC_0813 VC_0813 recN recN dnaJ dnaJ rpmE2 rpmE2 rpmJ2 rpmJ2 VC_0977 VC_0977 nth nth rnfC rnfC VC_1055 VC_1055 recR recR VC_1083 VC_1083 VC_1108 VC_1108 VC_1119 VC_1119 VC_1153 VC_1153 VC_1197 VC_1197 ihfA ihfA VC_1332 VC_1332 VC_1407 VC_1407 matP matP cobB cobB VC_1543 VC_1543 VC_1548 VC_1548 VC_1584 VC_1584 VC_1600 VC_1600 VC_1612 VC_1612 rplY rplY VC_1651 VC_1651 VC_1722 VC_1722 VC_1760 VC_1760 VC_1761 VC_1761 VC_1786 VC_1786 VC_1837 VC_1837 VC_1857 VC_1857 VC_1885 VC_1885 ihfB ihfB VC_1915 VC_1915 hupB hupB rpmF rpmF VC_2039 VC_2039 topB topB flhB flhB VC_2121 VC_2121 fliQ fliQ fliP fliP VC_2124 VC_2124 VC_2125 VC_2125 VC_2126 VC_2126 VC_2127 VC_2127 VC_2128 VC_2128 VC_2131 VC_2131 fliG fliG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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co-expression
protein homology
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VC_2133Flagellar M-ring protein FliF; The M ring may be actively involved in energy transduction. Belongs to the FliF family. (580 aa)
fliEFlagellar hook-basal body complex protein FliE; Similar to PID:2338730; identified by sequence similarity; putative. (109 aa)
fliDFlagellar hook-associated protein FliD; Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity). (666 aa)
flaDFlagellin FlaD; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaD is not essential for flagellar synthesis and motility. (377 aa)
flaEFlagellin FlaE; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaE is not essential for flagellar synthesis and motility. (378 aa)
flaAFlagellin core protein A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motility; important for full virulence. (379 aa)
flgIFlagellar P-ring protein FlgI; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (361 aa)
flgHFlagellar L-ring protein FlgH; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (261 aa)
VC_2195Flagellar basal-body rod protein FlgG; Similar to GB:U00096 SP:P75939 PID:1787318; identified by sequence similarity; putative; Belongs to the flagella basal body rod proteins family. (262 aa)
VC_2196Flagellar basal-body rod protein FlgF; Similar to GB:U00096 SP:P75938 PID:1787317; identified by sequence similarity; putative; Belongs to the flagella basal body rod proteins family. (249 aa)
VC_2197Flagellar hook protein FlgE; Similar to GB:X51737 SP:P16322 GB:X52093 PID:47673; identified by sequence similarity; putative. (434 aa)
VC_2199Flagellar basal-body rod protein FlgC; Similar to GB:U00096 SP:P75935 PID:1787314; identified by sequence similarity; putative; Belongs to the flagella basal body rod proteins family. (138 aa)
VC_2200Flagellar basal-body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (131 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (247 aa)
rpsBRibosomal protein S2; Similar to GB:D26562 SP:P02351 GB:V00343 PID:42842 PID:473824; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS2 family. (242 aa)
VC_2303Conserved hypothetical protein; Identified by Glimmer2; putative. (193 aa)
csdAminotransferase, class V; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (404 aa)
VC_2340Conserved hypothetical protein; Identified by Glimmer2; putative. (384 aa)
VC_2341long-chain-fatty-acid--CoA ligase, putative; Similar to GB:AE000782; identified by sequence similarity; putative. (563 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (241 aa)
VC_2497Conserved hypothetical protein; Identified by Glimmer2; putative. (417 aa)
VC_2502DNA polymerase III, chi subunit; Similar to SP:P28905 SP:P11649 GB:L04574 GB:X15130 GB:Z14155; identified by sequence similarity; putative. (149 aa)
rplQRibosomal protein L17; Similar to GB:J01685 SP:P02416 GB:X00766 PID:147716 PID:42800; identified by sequence similarity; putative. (128 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpmDRibosomal protein L30; Similar to GB:L42023 SP:P44366 PID:1005798 PID:1220890 PID:1205044; identified by sequence similarity; putative. (58 aa)
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (167 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpsNRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rplXRibosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (105 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa)
rpmCRibosomal protein L29; Similar to SP:P02429 PID:42834 PID:606246 GB:U00096 PID:1789708; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uL29 family. (63 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (233 aa)
rplVRibosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (110 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa)
rplDRibosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). As the V.cholerae S10 leader can be regulated in vitro by the E.coli L4 protein this suggests the endogenous protein controls its own S10 operon in a similar fashion. (200 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (209 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
priAPrimosomal protein N`; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (734 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (72 aa)
dtdConserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (144 aa)
parBParB family protein; Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity). (293 aa)
VC_A0042Hypothetical protein; May act as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Increasing levels of c-di-GMP lead to decreased motility (Potential). Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP) with a dissociation constant of 170 nM in the presence of 10 mM KCl and with 100 nM in its absence. Binds 1 to 2 c-di-GMP per subunit. Only 1 c-di- GMP is seen in the wild-type crystal, while 2 are seen in the mutant. Depending on the concentration of K(+) stoichiometries of 1:1, 1.43:1 and 2:1 are determined by is [...] (252 aa)
VC_A0061ATP-dependent RNA helicase, DEAD box family; Similar to GB:L02123 SP:P25888 PID:560801 GB:U00096 PID:1651360; identified by sequence similarity; putative; Belongs to the DEAD box helicase family. (452 aa)
VC_A0168Hypothetical protein; Identified by Glimmer2; putative. (180 aa)
VC_A0169Hypothetical protein; Identified by Glimmer2; putative. (203 aa)
VC_A0170Hypothetical protein; Identified by Glimmer2; putative. (215 aa)
VC_A0172Conserved hypothetical protein; Identified by Glimmer2; putative. (318 aa)
VC_A0189Response regulator; Similar to PID:1736859 PID:1736868; identified by sequence similarity; putative. (334 aa)
rhlEATP-dependent RNA helicase RhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (451 aa)
VC_A0283Hypothetical protein; Identified by Glimmer2; putative. (407 aa)
rpmIRibosomal protein L35; Similar to GP:3095163; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
VC_A0405Hypothetical protein; Identified by Glimmer2; putative. (206 aa)
VC_A0447Haemagglutinin associated protein; Similar to GB:X64387 PID:396849 PID:48357; identified by sequence similarity; putative; Belongs to the N(4)/N(6)-methyltransferase family. (230 aa)
VC_A0490Lipase, GDXG family; Similar to GB:AE000782; identified by sequence similarity; putative. (337 aa)
VC_A0593Hypothetical protein; Identified by Glimmer2; putative. (310 aa)
VC_A0681Conserved hypothetical protein; Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG. Also displays 5'-nucleotidase activity, further hydrolyzing 5'-pApG to 5'-ApG. Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels. Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo. Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation. Is specific for 3'3'-cGAMP since it cannot degrade ot [...] (431 aa)
VC_A0735Hypothetical protein; Identified by Glimmer2; putative. (236 aa)
deaDATP-dependent RNA helicase DeaD; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (663 aa)
VC_A0832Methyltransferase, putative; Similar to SP:P37431 PID:295895; identified by sequence similarity; putative. (210 aa)
VC_A0840Deoxycytidylate deaminase, putative; Similar to SP:P33968 GB:X70289 PID:396216; identified by sequence similarity; putative. (161 aa)
VC_A0895Chemotactic transducer-related protein; Similar to PID:1652854; identified by sequence similarity; putative. (981 aa)
VC_A0994Hypothetical protein; Identified by Glimmer2; putative. (326 aa)
VC_A1107Hypothetical protein; Identified by Glimmer2; putative. (125 aa)
VC_A1106Hypothetical protein; Identified by Glimmer2; putative. (93 aa)
rpmHRibosomal protein L34; Similar to GB:L42023 SP:P44370 PID:1006197 PID:1221112 PID:1205248; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL34 family. (45 aa)
dnaAChromosomal DNA replication initiator DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (472 aa)
recFrecF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). (363 aa)
VC_0050DNA topoisomerase I-related protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677; identified by sequence similarity; putative. (190 aa)
VC_0097Flagellar protein FliL, putative; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (136 aa)
repATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (671 aa)
VC_0175Deoxycytidylate deaminase-related protein; Similar to GB:AE000782; identified by sequence similarity; putative. (532 aa)
VC_0196ATP-dependent DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221; identified by sequence similarity; putative. (620 aa)
slmATranscriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (210 aa)
VC_0217DNA repair protein RadC; Similar to GB:L42023 SP:P44952 PID:1006105 PID:1221061 PID:1205201; identified by sequence similarity; putative; Belongs to the UPF0758 family. (224 aa)
rpmBRibosomal protein L28; Similar to GB:L42023 SP:P44364 PID:1006103 PID:1221060 PID:1205200; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpmGRibosomal protein L33; Similar to GB:J01677 SP:P02436 PID:147709 PID:290486 GB:U00096; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
kdkAConserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. (251 aa)
hupADNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (90 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (618 aa)
fisFactor-for-inversion stimulation protein; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (98 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (162 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (121 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (122 aa)
priBPrimosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (100 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (149 aa)
VC_0371Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa)
VC_0404MSHA biogenesis protein MshN; Similar to PID:791156 PID:791158; identified by sequence similarity; putative. (389 aa)
VC_0415Rod shape-determining protein MreB; Similar to SP:P13519 GB:M22055 PID:606191 PID:1128967 GB:U00096; identified by sequence similarity; putative. (347 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpmARibosomal protein L27; Similar to GB:D13267 SP:P02427 PID:216637 PID:606123 GB:U00096; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL27 family. (86 aa)
VC_0510DNA repair protein RadC-related protein; Similar to PID:1208991 GB:U00096 PID:1552815 PID:2367100; identified by sequence similarity; putative; Belongs to the UPF0758 family. (157 aa)
rpsURibosomal protein S21; Similar to GB:J01687 SP:P02379 GB:V00346 PID:147754 PID:42868; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bS21 family. (71 aa)
VC_A1114ParB family protein; Similar to SP:P08867 GB:M12987 GB:X04619 PID:148592 PID:42432; identified by sequence similarity; putative; Belongs to the ParB family. (323 aa)
rpsPRibosomal protein S16; Similar to SP:P02372 PID:43143 GB:U00096 PID:1788961; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bS16 family. (82 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpsIRibosomal protein S9; Similar to GB:X02130 SP:P02363 PID:535073 PID:606169 GB:U00096; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS9 family. (130 aa)
VC_0577Stringent starvation protein B; Similar to GB:M69028 SP:P25663 GB:X05088 PID:147872 PID:42999; identified by sequence similarity; putative. (158 aa)
VC_0608iron(III) ABC transporter, periplasmic iron-compound-binding protein; Similar to PID:1651916; identified by sequence similarity; putative. (352 aa)
infBInitiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (898 aa)
rpsORibosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
srmBATP-dependent RNA helicase SrmB; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily. (423 aa)
VC_0676nptA protein; Similar to GP:3646477; identified by sequence similarity; putative. (382 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (86 aa)
VC_0706Sigma-54 modulation protein, putative; Similar to SP:P11285 PID:147173 PID:147179 PID:1246515 GB:U00096; identified by sequence similarity; putative. (108 aa)
rdgCConserved hypothetical protein; May be involved in recombination; Belongs to the RdgC family. (304 aa)
cutCCopper homeostasis protein; Participates in the control of copper homeostasis. Belongs to the CutC family. (254 aa)
guaBInosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
VC_0811Hypothetical protein; Identified by Glimmer2; putative. (234 aa)
VC_0813Tellurite resistance protein-related protein; Similar to GB:M74072 SP:P25397 PID:149018 GB:U00096 PID:1742337; identified by sequence similarity; putative. (192 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (554 aa)
dnaJdnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] (381 aa)
rpmE2Ribosomal protein, L31P family; Similar to GB:U00096 PID:1657496 PID:2367109; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily. (85 aa)
rpmJ2Ribosomal protein L36, putative; Similar to SP:P28528; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL36 family. (41 aa)
VC_0977Conserved hypothetical protein; Identified by Glimmer2; putative. (306 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)
rnfCRnfC-related protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (801 aa)
VC_1055Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (120 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (200 aa)
VC_1083Hypothetical protein; Identified by Glimmer2; putative. (194 aa)
VC_1108Conserved hypothetical protein; Identified by Glimmer2; putative. (449 aa)
VC_1119Oxidoreductase, short-chain dehydrogenase/reductase family; Similar to SP:P25970; identified by sequence similarity; putative. (241 aa)
VC_1153Conserved hypothetical protein; Identified by Glimmer2; putative. (202 aa)
VC_1197Hypothetical protein; Identified by Glimmer2; putative. (231 aa)
ihfAIntegration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (98 aa)
VC_1332Conserved hypothetical protein; Identified by Glimmer2; putative. (509 aa)
VC_1407ATP-dependent RNA helicase RhlE; Similar to GP:3288677; identified by sequence similarity; putative; Belongs to the DEAD box helicase family. (397 aa)
matPConserved hypothetical protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. (169 aa)
cobBNicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. (259 aa)
VC_1543Hypothetical protein; Identified by Glimmer2; putative. (392 aa)
VC_1548Hypothetical protein; Identified by Glimmer2; putative. (252 aa)
VC_1584ankB protein; Similar to PID:563740 PID:1754534; identified by sequence similarity; putative. (188 aa)
VC_1600Hypothetical protein; Identified by Glimmer2; putative. (229 aa)
VC_1612Fimbrial biogenesis and twitching motility protein, putative; Similar to PID:1162960; identified by sequence similarity; putative. (237 aa)
rplYRibosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (92 aa)
VC_1651Response regulator VieB; Similar to GP:3123892; identified by sequence similarity; putative. (553 aa)
VC_1722Conserved hypothetical protein; Identified by Glimmer2; putative. (195 aa)
VC_1760Helicase, putative; Similar to GB:AL009126; identified by sequence similarity; putative. (940 aa)
VC_1761Hypothetical protein; Identified by Glimmer2; putative. (202 aa)
VC_1786DNA repair protein RadC, putative; Similar to PID:1208991 GB:U00096 PID:1552815 PID:2367100; identified by sequence similarity; putative; Belongs to the UPF0758 family. (158 aa)
VC_1837tolA protein; Similar to GB:M28232 SP:P19934 PID:148019 GB:U00096 PID:1651331; identified by sequence similarity; putative. (356 aa)
VC_1857Primosomal replication protein N``; Similar to GB:D13958 PID:912452 GB:U00096 PID:1773149 PID:1786673; identified by sequence similarity; putative. (187 aa)
VC_1885Hypothetical protein; Identified by Glimmer2; putative. (191 aa)
ihfBIntegration host factor, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (92 aa)
VC_1915Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (556 aa)
hupBDNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (90 aa)
rpmFRibosomal protein L32; Similar to GB:L42023 SP:P44368 PID:1003217 PID:1222072 PID:1204415; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL32 family. (56 aa)
VC_2039Conserved hypothetical protein; Identified by Glimmer2; putative. (333 aa)
topBDNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (647 aa)
flhBFlagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (376 aa)
VC_2121Flagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (260 aa)
fliQFlagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliPFlagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (299 aa)
VC_2124Flagellar protein FliO; Similar to GB:L22182 SP:P22586 PID:347242 GB:U00096 PID:1736613; identified by sequence similarity; putative. (129 aa)
VC_2125Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (138 aa)
VC_2126Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (349 aa)
VC_2127Flagellar protein FliL, putative; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (167 aa)
VC_2128Flagellar hook-length control protein FliK, putative; Similar to PID:894083 SP:P52614 GB:U00096 PID:1736609 PID:1788253; identified by sequence similarity; putative. (674 aa)
VC_2131Flagellar assembly protein FliH, putative; Similar to GB:M62408 SP:P15934 GB:X52093 PID:154028; identified by sequence similarity; putative. (270 aa)
fliGFlagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). (348 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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