STRINGSTRING
ligA ligA rnt rnt dnaX dnaX VC_1234 VC_1234 VC_1290 VC_1290 VC_1542 VC_1542 VC_1918 VC_1918 VC_2015 VC_2015 VC_2045 VC_2045 dnaQ dnaQ dnaE dnaE VC_2417 VC_2417 VC_2502 VC_2502 dam dam VC_2694 VC_2694 VC_A0005 VC_A0005 VC_A0163 VC_A0163 VC_A0953 VC_A0953 VC_A0717 VC_A0717 dnaN dnaN lexA lexA rep rep VC_0190 VC_0190 VC_0264 VC_0264 VC_0299 VC_0299 VC_0334 VC_0334 mutL mutL ssb ssb surA surA mutS mutS VC_0656 VC_0656 mutH mutH xseA xseA xseB xseB VC_0953 VC_0953
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (669 aa)
rntRibonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. (243 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (692 aa)
VC_1234Similar to SP:P04995 GB:J02641 GB:U00009 PID:405954 PID:147788; identified by sequence similarity; putative. (474 aa)
VC_1290DNA polymerase III, epsilon subunit, putative; Similar to GB:AE000782; identified by sequence similarity; putative. (236 aa)
VC_1542DNA ligase; Similar to SP:P44121; identified by sequence similarity; putative. (282 aa)
VC_1918Peptidyl-prolyl cis-trans isomerse D; Similar to GB:U00096 SP:P77241 PID:1580712 PID:1773125 PID:1786645; identified by sequence similarity; putative. (619 aa)
VC_2015DNA polymerase III, delta prime subunit; Similar to GB:L01483 SP:P28631 GB:L04577 PID:145783 PID:145799; identified by sequence similarity; putative. (324 aa)
VC_2045Superoxide dismutase, Fe; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (194 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (247 aa)
dnaEDNA polymerase III, alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. (1164 aa)
VC_2417single-stranded-DNA-specific exonuclease RecJ; Similar to GB:M54884 SP:P21893 PID:147550 PID:887842 GB:U00096; identified by sequence similarity; putative. (584 aa)
VC_2502DNA polymerase III, chi subunit; Similar to SP:P28905 SP:P11649 GB:L04574 GB:X15130 GB:Z14155; identified by sequence similarity; putative. (149 aa)
damDNA adenine methylase; Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair; Belongs to the N(4)/N(6)-methyltransferase family. (277 aa)
VC_2694Superoxide dismutase, Mn; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
VC_A0005Hypothetical protein; Identified by Glimmer2; putative. (92 aa)
VC_A0163Conserved hypothetical protein; Identified by Glimmer2; putative. (70 aa)
VC_A0953Peptidyl-prolyl cis-trans isomerase C; Similar to SP:P39159 PID:836657 PID:693800 GB:U00096 PID:1790211; identified by sequence similarity; putative. (92 aa)
VC_A0717Helicase IV; Similar to GB:J04726 SP:P15038 PID:146328 GB:U00096 PID:1651467; identified by sequence similarity; putative. (699 aa)
dnaNDNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (366 aa)
lexALexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (209 aa)
repATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (671 aa)
VC_0190DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738; identified by sequence similarity; putative. (723 aa)
VC_0264Conserved hypothetical protein; Identified by Glimmer2; putative. (455 aa)
VC_0299DNA polymerase III, epsilon subunit, putative; Similar to GB:AE000657; identified by sequence similarity; putative. (223 aa)
VC_0334Hypothetical protein; Identified by Glimmer2; putative. (319 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). (653 aa)
ssbSingle-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (177 aa)
surASurvival protein SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (431 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (862 aa)
VC_0656DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (135 aa)
mutHDNA mismatch repair protein MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. (221 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (446 aa)
xseBExodeoxyribonuclease, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
VC_0953DNA polymerase III, delta subunit; Similar to GB:L04576 SP:P28630 GB:M94267 PID:145729 PID:145785; identified by sequence similarity; putative. (342 aa)
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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