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purE purE purK purK purC purC pyrB pyrB pyrI pyrI purH purH purD purD CV_0578 CV_0578 purA1 purA1 CV_0803 CV_0803 thyA thyA folA folA glyA glyA guaB guaB kbl kbl tdh tdh pyrD pyrD folD folD purU purU argI argI purL purL purF purF guaC guaC pyrF pyrF gcvP gcvP gcvH gcvH gcvT gcvT guaA guaA purA2 purA2 pydA pydA purM purM purN purN uraA uraA CV_3746 CV_3746 gmk gmk CV_3771 CV_3771 apt apt carB carB carA carA purB purB hpT hpT pyrE pyrE CV_4309 CV_4309 pyrC pyrC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (376 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by sequence similarity; putative; ORF located using Blastx/COG0152; Belongs to the SAICAR synthetase family. (284 aa)
pyrBAspartate carbamoyltransferase catalytic chain; Identified by sequence similarity; putative; ORF located using Blastx/COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (302 aa)
pyrIAspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0138. (525 aa)
purDPhosphoribosylamine-glycine ligase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0151; Belongs to the GARS family. (425 aa)
CV_0578Probable guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (438 aa)
purA1Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
CV_0803Probable 5-aminolevulinate synthase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0156. (403 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (165 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
kblGlycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (399 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa)
folDMethylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa)
argIOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (307 aa)
purLPhophoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1319 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (509 aa)
guaCProbable GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (316 aa)
pyrFOrotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (247 aa)
gcvPGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (950 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (362 aa)
guaAGMP synthetase; Catalyzes the synthesis of GMP from XMP. (525 aa)
purA2Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
pydADihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (316 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0150. (345 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (213 aa)
uraAUracil permease; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2233/TC:2.A.40.1.1. (413 aa)
CV_3746Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG0518. (232 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa)
CV_3771Probable membrane permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2252/TC:2.A.40.3.1. (432 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (193 aa)
carBCarbamoyl-phosphate synthase large chain; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0458; Belongs to the CarB family. (1069 aa)
carACarbomyl phosphate synthetase small subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0505; Belongs to the CarA family. (375 aa)
purBAdenylosuccinate lyase; Identified by sequence similarity; putative; ORF located using Blastx/COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
hpTHypoxanthine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0634. (180 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa)
CV_4309Probable L-allo-threonine aldolase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2008. (342 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (361 aa)
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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