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aceE aceE aceF aceF lpdA1 lpdA1 maeB maeB mdh mdh sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB gtlA gtlA sucA sucA sucB sucB lpdA2 lpdA2 sucC sucC sucD sucD fumC fumC acnA1 acnA1 CV_1518 CV_1518 CV_1809 CV_1809 CV_2031 CV_2031 CV_2037 CV_2037 CV_2053 CV_2053 acnA2 acnA2 prpC prpC prpB prpB acnB acnB CV_2788 CV_2788 frdD frdD frdC frdC frdB frdB frdA frdA fumA fumA CV_3664 CV_3664 goaG goaG gabD gabD CV_4092 CV_4092
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aceEPyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
aceFDihydrolipoamide S-acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (554 aa)
lpdA1Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1249. (599 aa)
maeBNADP-dependent malate dehydrogenase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0281. (761 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (326 aa)
sdhCSuccinate dehydrogenase cytochrome b-556 subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2009. (125 aa)
sdhDSuccinate dehydrogenase, hydrophobic subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2142. (114 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1053; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (591 aa)
sdhBSuccinate dehydrogenase iron-sulfur protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa)
gtlACitrate (si)-synthase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0372; Belongs to the citrate synthase family. (435 aa)
sucA2-oxoglutarate dehydrogenase E1 component; Identified by sequence similarity; putative; ORF located using Blastx/COG0567. (942 aa)
sucBDihydrolipoamide succinyltransferase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa)
lpdA2Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1249. (477 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (390 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
acnA1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa)
CV_1518Probable carboxyvinyl-carboxyphosphonate phosphorylmutase; Identified by sequence similarity; putative; ORF located using Glimmer/Blastx/COG2513. (302 aa)
CV_1809Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG2079. (434 aa)
CV_2031Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2828. (369 aa)
CV_2037Probable dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1249. (464 aa)
CV_2053Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2828. (396 aa)
acnA2Aconitate hydratase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1048. (868 aa)
prpCCitrate synthase 2; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0372; Belongs to the citrate synthase family. (382 aa)
prpBCarboxyvinyl-carboxyphosphonate phosphorylmutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (292 aa)
acnBAconitate hydratase; Identified by sequence similarity; putative; ORF located using Blastx/COG1049; Belongs to the aconitase/IPM isomerase family. (862 aa)
CV_2788Probable isomerase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0179. (216 aa)
frdDFumarate reductase, subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane; Belongs to the FrdD family. (120 aa)
frdCFumarate reductase, subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane; Belongs to the FrdC family. (132 aa)
frdBFumarate reductase, subunit B; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0479. (248 aa)
frdAFumarate reductase flavoprotein subunit; Identified by sequence similarity; putative; ORF located using Blastx/COG1053. (591 aa)
fumAFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa)
CV_3664Probable isocitrate dehydrogenase (NADP); Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2838; Belongs to the monomeric-type IDH family. (745 aa)
goaG4-aminobutyrate transaminase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
gabDSuccinate-semialdehyde dehydrogenase [NAD(P)]; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1012; Belongs to the aldehyde dehydrogenase family. (486 aa)
CV_4092Probable aldehyde dehydrogenase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1012. (451 aa)
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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