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cpdB cpdB pyrB pyrB pyrI pyrI thyA thyA udk udk nrdE nrdE ushA ushA pyrD pyrD CV_1813 CV_1813 pyrH pyrH nrdB nrdB nrdA nrdA tdk tdk nrdD nrdD cdd cdd pyrF pyrF cmk cmk dut dut CV_3083 CV_3083 pyrG pyrG ndk ndk pydA pydA dcd dcd upp upp surE surE deoD deoD deoA deoA tmk tmk carB carB carA carA pyrE pyrE pyrC pyrC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cpdB2`,3`-cyclic-nucleotide 2`-phosphodiesterase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0737; Belongs to the 5'-nucleotidase family. (634 aa)
pyrBAspartate carbamoyltransferase catalytic chain; Identified by sequence similarity; putative; ORF located using Blastx/COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (302 aa)
pyrIAspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
udkUridine kinase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0572. (204 aa)
nrdERibonucleotide reductase system; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (950 aa)
ushAUDP-sugar diphosphatase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0737; Belongs to the 5'-nucleotidase family. (548 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa)
CV_1813Probable nitroreductase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0778. (196 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
nrdBRibonucleoside-diphosphate reductase system; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (360 aa)
nrdARibonucleoside-diphosphate reductase system; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (972 aa)
tdkThymidine kinase; Identified by sequence similarity; putative; ORF located using Blastx/COG1435. (184 aa)
nrdDRibonucleoside-triphosphate reductase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG1328. (712 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (166 aa)
pyrFOrotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (247 aa)
cmkCytidylate kinase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0283. (222 aa)
dutdUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa)
CV_3083Probable UDP-sugar diphosphatase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0737; Belongs to the 5'-nucleotidase family. (566 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (546 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
pydADihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (316 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (190 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (247 aa)
deoDPurine nucleoside phosphorylase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0813. (236 aa)
deoAThymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (441 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
carBCarbamoyl-phosphate synthase large chain; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0458; Belongs to the CarB family. (1069 aa)
carACarbomyl phosphate synthetase small subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0505; Belongs to the CarA family. (375 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (361 aa)
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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