STRINGSTRING
lasB lasB fadD1 fadD1 aroG aroG CV_0281 CV_0281 CV_0311 CV_0311 CV_0405 CV_0405 oprM oprM CV_0464 CV_0464 CV_0594 CV_0594 CV_0738 CV_0738 CV_0800 CV_0800 qseB qseB qseC qseC plcN plcN potF2 potF2 secG secG secB secB ribD ribD yajC yajC fadD2 fadD2 aroF aroF livH livH livM livM livG livG livF livF CV_1539 CV_1539 kdpE kdpE CV_1678 CV_1678 CV_1679 CV_1679 CV_1680 CV_1680 CV_1681 CV_1681 CV_1737 CV_1737 CV_1744 CV_1744 CV_1979 CV_1979 CV_1980 CV_1980 CV_1981 CV_1981 ribA ribA pabA pabA trpE trpE ibeB ibeB CV_2481 CV_2481 lasA lasA armS armS CV_2635 CV_2635 CV_2685 CV_2685 CV_2686 CV_2686 CV_2687 CV_2687 CV_2822 CV_2822 CV_2987 CV_2987 zur zur CV_3205 CV_3205 CV_3270 CV_3270 vioD vioD vioC vioC vioB vioB vioA vioA pabB pabB CV_3483 CV_3483 CV_3484 CV_3484 hfq hfq ffh ffh CV_3936 CV_3936 CV_4051 CV_4051 cviR cviR cviI cviI secY secY secE secE ftsY ftsY potF1 potF1 CV_4218 CV_4218 CV_4220 CV_4220 secA secA oppF oppF oppD oppD oppC oppC oppB oppB CV_4329 CV_4329 yidC yidC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lasBClass 4 metalloprotease; Extracellular zinc metalloprotease. (489 aa)
fadD1Long chain fatty-acid CoA ligase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0318/TC:9.B.17.1.4. (551 aa)
aroGPhospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (352 aa)
CV_0281Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG3238. (172 aa)
CV_0311Probable RTX (repeat in structural toxin); Identified by sequence similarity; putative; ORF located using Blastx/COG2931. (4130 aa)
CV_0405Probable amino acid ABC transporter; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0683/TC:3.A.1.4.1. (384 aa)
oprMOuter membrane efflux protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1538. (466 aa)
CV_0464Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. (1854 aa)
CV_0594Probable two-component sensor histidine kinase protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0642. (467 aa)
CV_0738Probable transcriptional regulator Crp/Fnr-family; Identified by sequence similarity; putative; ORF located using Blastx/COG0664. (232 aa)
CV_0800Probable oligopeptide ABC transporter system, substrate-binding protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0747/TC:3.A.1.5.1. (532 aa)
qseBTranscriptional regulatory protein qseB; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0745. (220 aa)
qseCSensor protein qseC; Identified by sequence similarity; putative; ORF located using Blastx/COG0642. (448 aa)
plcNNon-hemolytic phospholipase C precursor; Identified by sequence similarity; putative; ORF located using Blastx/COG3511. (656 aa)
potF2Polyamine ABC transporter system, substrate-binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (357 aa)
secGProtein-export integral membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (118 aa)
secBProtein-export protein; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (150 aa)
ribDDiaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (368 aa)
yajCProbable transmembrane protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (108 aa)
fadD2Long chain fatty-acid CoA ligase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0318. (559 aa)
aroF2-dehydro-3-deoxy-phosphoheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (368 aa)
livHLeucine/isoleucine/valine transport system permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0559/TC:3.A.1.4.1; Belongs to the binding-protein-dependent transport system permease family. (309 aa)
livMLeucine/isoleucine/valine transport system permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0559/TC:3.A.1.4.1; Belongs to the binding-protein-dependent transport system permease family. (363 aa)
livGLeucine/isoleucine/valine transport system ATP-binding protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0411. (256 aa)
livFLeucine/isoleucine/valine transport system ATP-binding protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0410. (236 aa)
CV_1539Probable amino acid ABC transporter; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0683. (407 aa)
kdpEKdp operon transcriptional regulatory protein kdpE; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0745. (244 aa)
CV_1678Probable ABC transporter, ATP-binding protein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG1130; Belongs to the ABC transporter superfamily. (335 aa)
CV_1679Probable ABC transporter, permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1177/TC:3.A.1.6.3. (266 aa)
CV_1680Probable permease of ABC transporter; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1176/TC:3.A.1.20.1. (303 aa)
CV_1681Probable ABC transporter, periplasmic binding protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1840/TC:3.A.1.11.1. (366 aa)
CV_1737Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/Blastx. (2031 aa)
CV_1744Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx. (114 aa)
CV_1979Probable ABC transporter, permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0601/TC:3.A.1.5.3. (312 aa)
CV_1980Probable ABC trasporter, permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1173/TC:3.A.1.5.2. (352 aa)
CV_1981Probable ABC transporter, ATP-binding protein; Identified by sequence similarity; putative; ORF located using Glimmer/Blastx/COG1123/TC:3.A.1.5.2; Belongs to the ABC transporter superfamily. (569 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (205 aa)
pabAAnthranilate synthase (component II); Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0512. (189 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (488 aa)
ibeBOuter membrane drug efflux lipoprotein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1538/TC:1.B.17.3.5. (459 aa)
CV_2481Probable amino acid ABC transporter; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0683. (401 aa)
lasALasA protease precursor; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0739. (412 aa)
armSTwo-component sensor kinase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0642. (414 aa)
CV_2635Probable two-component response regulator; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0745. (221 aa)
CV_2685Probable ABC transporter ATP-binding protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1123/TC:3.A.1.5.2; Belongs to the ABC transporter superfamily. (567 aa)
CV_2686Probable ABC trasporter, permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1173/TC:3.A.1.5.2. (351 aa)
CV_2687Probable ABC transporter, permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0601/TC:3.A.1.5.2. (313 aa)
CV_2822Probable amino acid ABC transporter; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0683. (382 aa)
CV_2987Probable transcription regulator, Crp/Fnr family; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0664. (228 aa)
zurTranscriptional repressor of znuABC operon; Identified by sequence similarity; putative; ORF located using Glimmer/Blastx/COG0735; Belongs to the Fur family. (117 aa)
CV_3205Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0643. (368 aa)
CV_3270Hypothetical protein. (191 aa)
vioDvioD - hydroxylase; Catalyzes the oxygenation of the 6-position of protodeoxyviolaceinate to form proviolacein. (373 aa)
vioCvioC monooxygenase; Catalyzes the hydroxylation of the 16-position of protoviolaceinate and protodeoxyviolaceinate to form violacein and deoxyviolacein, respectively. (429 aa)
vioBVioB - polyketide synthase; Catalyzes the hydrogen peroxide-dependent dimerization of two L-tryptophan-derived molecules (imine form of indole 3-pyruvate (IPA)), to form an uncharacterized product suggested to be indole-3-pyruvate imine dimer that can spontaneously convert into dichlorochromopyrrolate (CPA). The uncharacterized product is the substrate of VioE. (998 aa)
vioAvioA - tryptophan 2-monooxygenase; The enzyme generates the imine form of indole 3-pyruvate (IPA) from L-tryptophan (L-Trp), with concomitant two-electron reduction of O(2) to H(2)O(2). (418 aa)
pabBAnthranilate synthase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0147. (430 aa)
CV_3483Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG3238. (156 aa)
CV_3484Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG3238. (150 aa)
hfqHost factor-I protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (86 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (451 aa)
CV_3936Probable binding protein component of ABC dipeptide transporter; Identified by sequence similarity; putative; ORF located using Glimmer/Blastx/COG0747/TC:3.A.1.5.5. (554 aa)
CV_4051Probable long chain fatty-acid CoA ligase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1022. (587 aa)
cviRTranscriptional activator, LuxR/UhpA family of regulators; Identified by sequence similarity; putative; ORF located using Blastx/COG2771. (265 aa)
cviIN-acyl homoserine synthase; Identified by sequence similarity; putative; ORF located using Blastx/COG3916. (217 aa)
secYPreprotein translocase secY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (439 aa)
secEPreprotein translocase transmembrane,secE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (118 aa)
ftsYCell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (375 aa)
potF1Polyamine ABC transporter system, substrate-binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (357 aa)
CV_4218Probable two-component system sensor kinase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0642. (467 aa)
CV_4220Probable two-component transcriptional regulator; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2204. (446 aa)
secAPreprotein translocase secA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (903 aa)
oppFOligopeptide ABC transport system ATP-binding protein OppF; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1124/TC:3.A.1.5.1; Belongs to the ABC transporter superfamily. (329 aa)
oppDOligopeptide transport system ATP-binding protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0444/TC:3.A.1.5.1; Belongs to the ABC transporter superfamily. (333 aa)
oppCOligopeptide transport system permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1173/TC:3.A.1.5.1. (304 aa)
oppBOligopeptide transport system permease protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0601/TC:3.A.1.5.1. (306 aa)
CV_4329Probable oligopeptide ABC transporter system, substrate-binding protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0747/TC:3.A.1.5.1. (537 aa)
yidCIntegral membrane protein, 60 kDa; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (545 aa)
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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