STRINGSTRING
KGF64455.1 KGF64455.1 KGF64471.1 KGF64471.1 KGF64472.1 KGF64472.1 KGF64912.1 KGF64912.1 KGF64915.1 KGF64915.1 lexA lexA KGF64928.1 KGF64928.1 KGF64929.1 KGF64929.1 dnaE2 dnaE2 lexA-2 lexA-2 KGF65786.1 KGF65786.1 topA topA KGF65858.1 KGF65858.1 dnaX dnaX KGF66103.1 KGF66103.1 KGF66247.1 KGF66247.1 KGF66322.1 KGF66322.1 dinG dinG rnt rnt dnaQ dnaQ KGF62941.1 KGF62941.1 sbcD sbcD KGF62978.1 KGF62978.1 KGF63049.1 KGF63049.1 dinB dinB recA recA mutS mutS KGF63227.1 KGF63227.1 KGF63488.1 KGF63488.1 KGF63594.1 KGF63594.1 KGF63640.1 KGF63640.1 KGF63641.1 KGF63641.1 KGF63647.1 KGF63647.1 KGF63818.1 KGF63818.1 mutL mutL KGF63928.1 KGF63928.1 priA priA KGF64067.1 KGF64067.1 KGF64101.1 KGF64101.1 rep rep recG recG uvrD uvrD dnaA dnaA KGF64326.1 KGF64326.1 recF recF polA polA KGF62567.1 KGF62567.1 KGF62596.1 KGF62596.1 dnaG dnaG KGF62061.1 KGF62061.1 topA-2 topA-2 KGF62118.1 KGF62118.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KGF64455.1Recombination factor protein RarA; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
KGF64471.1Peptidase S24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S24 family. (146 aa)
KGF64472.1DNA polymerase V subunit UmuC; Derived by automated computational analysis using gene prediction method: Protein Homology. (426 aa)
KGF64912.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (758 aa)
KGF64915.1Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. (838 aa)
lexALexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (205 aa)
KGF64928.1CDP-6-deoxy-delta-3,4-glucoseen reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
KGF64929.1DNA repair nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
dnaE2DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1033 aa)
lexA-2LexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa)
KGF65786.1Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (167 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (867 aa)
KGF65858.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (635 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (717 aa)
KGF66103.1DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
KGF66247.1Controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DnaA family. HdA subfamily. (234 aa)
KGF66322.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
dinGATP-dependent DNA helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. (714 aa)
rntRibonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. (225 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (254 aa)
KGF62941.1Transcriptional regulator HU subunit alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
sbcDExonuclease SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (413 aa)
KGF62978.1Chromosome segregation protein SMC; Derived by automated computational analysis using gene prediction method: Protein Homology. (1215 aa)
KGF63049.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (708 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (352 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (354 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (859 aa)
KGF63227.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1173 aa)
KGF63488.1DNA polymerase III subunit chi; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
KGF63594.1Recombination and repair protein; May be involved in recombinational repair of damaged DNA. (557 aa)
KGF63640.1Helicase DnaB; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
KGF63641.1DNA replication protein DnaC; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
KGF63647.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
KGF63818.1DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (465 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (661 aa)
KGF63928.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (739 aa)
KGF64067.1Peptidase S24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S24 family. (113 aa)
KGF64101.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (643 aa)
repATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (669 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (691 aa)
uvrDDNA-dependent helicase II; Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; Derived by automated computational analysis using gene prediction method: Protein Homology. (727 aa)
dnaAChromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (511 aa)
KGF64326.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa)
recFRecombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (367 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (921 aa)
KGF62567.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
KGF62596.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (655 aa)
KGF62061.1Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (160 aa)
topA-2DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (679 aa)
KGF62118.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
Your Current Organism:
Pseudomonas lutea
NCBI taxonomy Id: 243924
Other names: CECT 5822, LMG 21974, LMG:21974, P. lutea, Pseudomonas lutea Peix et al. 2004, strain OK2
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