STRINGSTRING
FGFRL1 FGFRL1 LOC103390636 LOC103390636 LOC103390704 LOC103390704 LOC103390897 LOC103390897 fgf23 fgf23 fgf3 fgf3 lctl lctl fgf4 fgf4 fgf19 fgf19 klb klb LOC103395214 LOC103395214 LOC103384120 LOC103384120 fgfr3 fgfr3 fgf5 fgf5 LOC103391367 LOC103391367
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGFRL1Fibroblast growth factor receptor like 1. (496 aa)
LOC103390636Fibroblast growth factor receptor like 1a. (499 aa)
LOC103390704Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
LOC103390897Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (211 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (265 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)
lctlLactase-like b; Belongs to the glycosyl hydrolase 1 family. (570 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
klbKlotho beta. (1057 aa)
LOC103395214Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
LOC103384120Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
fgfr3Fibroblast growth factor receptor. (812 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
LOC103391367Fibroblast growth factor receptor 2. (661 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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