(23 nodes) Double-strand break repair via nonhomologous end joining, and Enkurin domain network (Cynoglossus semilaevis)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	ENSCSEP00000001772	Uncharacterized protein. (178 aa)
	dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (534 aa)
	LOC103388200	USP domain-containing protein; Belongs to the peptidase C19 family. (513 aa)
	dntt	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (490 aa)
	paxx	Uncharacterized protein. (197 aa)
	polm	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (531 aa)
	aptx	Aprataxin. (334 aa)
	top1	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (749 aa)
	tdp1	Tyrosyl-DNA phosphodiesterase 1. (569 aa)
	cnppd1	Cyclin Pas1/PHO80 domain containing 1. (442 aa)
	xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5. (736 aa)
	Xrcc4	Uncharacterized protein. (164 aa)
	ENSCSEP00000019101	DNA_pol_B_thumb domain-containing protein. (54 aa)
	ENSCSEP00000019257	X-ray repair complementing defective repair in Chinese hamster cells 1. (567 aa)
	ENSCSEP00000020864	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3778 aa)
	Lig4	DNA ligase. (922 aa)
	LOC103378278	Polynucleotide kinase 3'-phosphatase. (591 aa)
	lig3	DNA ligase. (1015 aa)
	ENSCSEP00000030201	HHH_8 domain-containing protein. (111 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1367 aa)
	LOC103397767	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
	enkd1	Enkurin domain containing 1. (316 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (623 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000001772	ENSCSEP00000019101	ENSCSEP00000001772	ENSCSEP00000019101	Uncharacterized protein.	DNA_pol_B_thumb domain-containing protein.	0.598
ENSCSEP00000001772	ENSCSEP00000019257	ENSCSEP00000001772	ENSCSEP00000019257	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.929
ENSCSEP00000001772	ENSCSEP00000020864	ENSCSEP00000001772	ENSCSEP00000020864	Uncharacterized protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.529
ENSCSEP00000001772	ENSCSEP00000030201	ENSCSEP00000001772	ENSCSEP00000030201	Uncharacterized protein.	HHH_8 domain-containing protein.	0.598
ENSCSEP00000001772	LOC103378278	ENSCSEP00000001772	ENSCSEP00000022883	Uncharacterized protein.	Polynucleotide kinase 3'-phosphatase.	0.573
ENSCSEP00000001772	LOC103397767	ENSCSEP00000001772	ENSCSEP00000030901	Uncharacterized protein.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.598
ENSCSEP00000001772	Lig4	ENSCSEP00000001772	ENSCSEP00000021786	Uncharacterized protein.	DNA ligase.	0.825
ENSCSEP00000001772	Xrcc4	ENSCSEP00000001772	ENSCSEP00000018942	Uncharacterized protein.	Uncharacterized protein.	0.832
ENSCSEP00000001772	aptx	ENSCSEP00000001772	ENSCSEP00000014850	Uncharacterized protein.	Aprataxin.	0.675
ENSCSEP00000001772	lig3	ENSCSEP00000001772	ENSCSEP00000023033	Uncharacterized protein.	DNA ligase.	0.775
ENSCSEP00000001772	paxx	ENSCSEP00000001772	ENSCSEP00000013257	Uncharacterized protein.	Uncharacterized protein.	0.495
ENSCSEP00000001772	tdp1	ENSCSEP00000001772	ENSCSEP00000016037	Uncharacterized protein.	Tyrosyl-DNA phosphodiesterase 1.	0.748
ENSCSEP00000001772	xrcc5	ENSCSEP00000001772	ENSCSEP00000016691	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 5.	0.949
ENSCSEP00000001772	xrcc6	ENSCSEP00000001772	ENSCSEP00000031858	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.917
ENSCSEP00000019101	ENSCSEP00000001772	ENSCSEP00000019101	ENSCSEP00000001772	DNA_pol_B_thumb domain-containing protein.	Uncharacterized protein.	0.598
ENSCSEP00000019101	ENSCSEP00000019257	ENSCSEP00000019101	ENSCSEP00000019257	DNA_pol_B_thumb domain-containing protein.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.911
ENSCSEP00000019101	ENSCSEP00000020864	ENSCSEP00000019101	ENSCSEP00000020864	DNA_pol_B_thumb domain-containing protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.574
ENSCSEP00000019101	LOC103378278	ENSCSEP00000019101	ENSCSEP00000022883	DNA_pol_B_thumb domain-containing protein.	Polynucleotide kinase 3'-phosphatase.	0.856
ENSCSEP00000019101	LOC103388200	ENSCSEP00000019101	ENSCSEP00000006804	DNA_pol_B_thumb domain-containing protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.472
ENSCSEP00000019101	Lig4	ENSCSEP00000019101	ENSCSEP00000021786	DNA_pol_B_thumb domain-containing protein.	DNA ligase.	0.766