STRINGSTRING
tp63 tp63 LOC103383534 LOC103383534 ENSCSEP00000005323 ENSCSEP00000005323 dyrk2 dyrk2 LOC103386083 LOC103386083 mdm4 mdm4 tchp tchp LOC103379434 LOC103379434 banp banp ENSCSEP00000029883 ENSCSEP00000029883
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tp63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (574 aa)
LOC103383534Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (139 aa)
ENSCSEP00000005323MDM2 proto-oncogene. (416 aa)
dyrk2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (592 aa)
LOC103386083Dual specificity tyrosine phosphorylation regulated kinase 3. (601 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (495 aa)
tchpTrichoplein, keratin filament binding. (493 aa)
LOC103379434Si:dkey-24l11.2. (653 aa)
banpBTG3 associated nuclear protein. (437 aa)
ENSCSEP00000029883Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (558 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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