(21 nodes) Mixed, incl. NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, and Peroxisome proliferator-activated receptor network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCSEP00000000321	Uncharacterized protein. (455 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (507 aa)
	LOC103381159	Nuclear receptor coactivator 1. (1235 aa)
	LOC103388356	Nuclear receptor subfamily 1, group D, member 2a. (617 aa)
	LOC103386109	Vitamin D receptor b. (425 aa)
	LOC103384911	Nuclear receptor subfamily 1, group H, member 5. (471 aa)
	rxra	Retinoid X receptor, alpha a. (498 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (468 aa)
	ENSCSEP00000010137	E1A binding protein p300 b. (2546 aa)
	ENSCSEP00000012489	Uncharacterized protein. (449 aa)
	LOC103385110	Nuclear receptor subfamily 1, group D, member 4a. (576 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (468 aa)
	ENSCSEP00000014328	Nuclear receptor coactivator 3. (1559 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (478 aa)
	LOC103384092	CREB binding protein a. (2219 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (462 aa)
	carm1	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (558 aa)
	ENSCSEP00000029894	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b. (239 aa)
	RXRB	Retinoid X receptor beta. (470 aa)
	Ncoa3	Uncharacterized protein. (1423 aa)
	Pparg	NR LBD domain-containing protein. (802 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000000321	ENSCSEP00000010137	ENSCSEP00000000321	ENSCSEP00000010137	Uncharacterized protein.	E1A binding protein p300 b.	0.553
ENSCSEP00000000321	ENSCSEP00000014328	ENSCSEP00000000321	ENSCSEP00000014328	Uncharacterized protein.	Nuclear receptor coactivator 3.	0.733
ENSCSEP00000000321	LOC103381159	ENSCSEP00000000321	ENSCSEP00000004691	Uncharacterized protein.	Nuclear receptor coactivator 1.	0.733
ENSCSEP00000000321	LOC103384092	ENSCSEP00000000321	ENSCSEP00000018479	Uncharacterized protein.	CREB binding protein a.	0.601
ENSCSEP00000000321	LOC103384911	ENSCSEP00000000321	ENSCSEP00000007684	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 5.	0.808
ENSCSEP00000000321	LOC103385110	ENSCSEP00000000321	ENSCSEP00000012501	Uncharacterized protein.	Nuclear receptor subfamily 1, group D, member 4a.	0.402
ENSCSEP00000000321	LOC103386109	ENSCSEP00000000321	ENSCSEP00000007573	Uncharacterized protein.	Vitamin D receptor b.	0.694
ENSCSEP00000000321	LOC103388356	ENSCSEP00000000321	ENSCSEP00000006514	Uncharacterized protein.	Nuclear receptor subfamily 1, group D, member 2a.	0.402
ENSCSEP00000000321	Ncoa3	ENSCSEP00000000321	ENSCSEP00000032634	Uncharacterized protein.	Uncharacterized protein.	0.733
ENSCSEP00000000321	PPARA	ENSCSEP00000000321	ENSCSEP00000014298	Uncharacterized protein.	Peroxisome proliferator-activated receptor alpha b.	0.737
ENSCSEP00000000321	Pparg	ENSCSEP00000000321	ENSCSEP00000033731	Uncharacterized protein.	NR LBD domain-containing protein.	0.945
ENSCSEP00000000321	RXRB	ENSCSEP00000000321	ENSCSEP00000031554	Uncharacterized protein.	Retinoid X receptor beta.	0.905
ENSCSEP00000000321	carm1	ENSCSEP00000000321	ENSCSEP00000021614	Uncharacterized protein.	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.532
ENSCSEP00000000321	nr1h3	ENSCSEP00000000321	ENSCSEP00000019485	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 3.	0.928
ENSCSEP00000000321	nr1h4	ENSCSEP00000000321	ENSCSEP00000009147	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 4.	0.808
ENSCSEP00000000321	ppara	ENSCSEP00000000321	ENSCSEP00000018071	Uncharacterized protein.	Peroxisome proliferator-activated receptor alpha a.	0.702
ENSCSEP00000000321	ppard	ENSCSEP00000000321	ENSCSEP00000002885	Uncharacterized protein.	Peroxisome proliferator-activated receptor delta b.	0.947
ENSCSEP00000000321	rxra	ENSCSEP00000000321	ENSCSEP00000008003	Uncharacterized protein.	Retinoid X receptor, alpha a.	0.906
ENSCSEP00000010137	ENSCSEP00000000321	ENSCSEP00000010137	ENSCSEP00000000321	E1A binding protein p300 b.	Uncharacterized protein.	0.553
ENSCSEP00000010137	ENSCSEP00000012489	ENSCSEP00000010137	ENSCSEP00000012489	E1A binding protein p300 b.	Uncharacterized protein.	0.553